Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Dustin J. Maly"'
Autor:
Marilyn Parsons, Ben Parsons, Marissa Dean, Amy E. DeRocher, Zeba Islam, Dustin J. Maly, Bryan C. Jensen
Publikováno v:
Frontiers in Parasitology, Vol 2 (2023)
IntroductionThe protein serine/threonine kinase AEK1 is essential in the pathogenic stage of Trypanosoma brucei, the causative agent of African trypanosomiasis. AEK1 is a member of the AGC protein kinase family, although it is not closely related to
Externí odkaz:
https://doaj.org/article/1c8adc61c088481b82cf4080d8a8f6a2
Autor:
John C. Rose, Nicholas A. Popp, Christopher D. Richardson, Jason J. Stephany, Julie Mathieu, Cindy T. Wei, Jacob E. Corn, Dustin J. Maly, Douglas M. Fowler
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Numerous strategies exist to limit the off-target activity of CRISPR-Cas9 nucleases. Here the authors co-administer truncated gRNAs that block both Cas9 and high-fidelity Cas9 variants from cleaving at off-target sites.
Externí odkaz:
https://doaj.org/article/32953ad84ae148f1a96180fcc11e3524
Autor:
Aruna Shrestha, Kayode K. Ojo, Florian Koston, Bärbel Ruttkowski, Rama S.R. Vidadala, Carlie S. Dorr, Edelmar D. Navaluna, Grant R. Whitman, Kayleigh F. Barrett, Lynn K. Barrett, Matthew A. Hulverson, Ryan Choi, Samantha A. Michaels, Dustin J. Maly, Andrew Hemphill, Wesley C. Van Voorhis, Anja Joachim
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 10, Iss , Pp 9-19 (2019)
Cystoisosporosis is a leading diarrheal disease in suckling piglets. With the confirmation of resistance against the only available drug toltrazuril, there is a substantial need for novel therapeutics to combat the infection and its negative effects
Externí odkaz:
https://doaj.org/article/a1a719e47d4b426fa88a60a6c691ec34
Autor:
Abhisheka Bansal, Kayode K. Ojo, Jianbing Mu, Dustin J. Maly, Wesley C. Van Voorhis, Louis H. Miller
Publikováno v:
mBio, Vol 7, Iss 6 (2016)
ABSTRACT We used a sensitization approach that involves replacement of the gatekeeper residue in a protein kinase with one with a different side chain. The activity of the enzyme with a bulky gatekeeper residue, such as methionine, cannot be inhibite
Externí odkaz:
https://doaj.org/article/77983dde2f9846ecaed7044b4deeda32
Autor:
Vanessa Nguyen, Ethan Ahler, Katherine A. Sitko, Jason J. Stephany, Dustin J. Maly, Douglas M. Fowler
Publikováno v:
Protein Science.
Autor:
Anders I. Persson, William A. Weiss, Kevan M. Shokat, C. David James, Mitchel S. Berger, Jean L. Nakamura, Daniel W. Sirkis, Yvan H. Chanthery, Dustin J. Maly, Nan Li
Figure S2. Expression of potential targets of VX680 in human GBM cultures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ddf3541420f36394191db093577a2b7
https://doi.org/10.1158/1535-7163.22502434
https://doi.org/10.1158/1535-7163.22502434
Autor:
Scott A. Oakes, Feroz R. Papa, Bradley J. Backes, Dustin J. Maly, Grace E. Kim, Annie Hiniker, Rachel E. Warren, Rosa Meza-Acevedo, Micah J. Gliedt, Justin Peng, Rajarshi Ghosh, Maike Thamsen, Jenny Y. Qi, Paul C. Moore
KIRA8 and GSK-PKI induce distinct apoptotic markers in INS1 tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f01540573145c2470ed78f2d3839477
https://doi.org/10.1158/0008-5472.22422192.v1
https://doi.org/10.1158/0008-5472.22422192.v1
Autor:
Scott A. Oakes, Feroz R. Papa, Bradley J. Backes, Dustin J. Maly, Grace E. Kim, Annie Hiniker, Rachel E. Warren, Rosa Meza-Acevedo, Micah J. Gliedt, Justin Peng, Rajarshi Ghosh, Maike Thamsen, Jenny Y. Qi, Paul C. Moore
CRISPR/Cas9 guide oligos, genotyping/sequencing primers, and q-PCR primers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26ba83b902509eaa50fdf68b5fdaef36
https://doi.org/10.1158/0008-5472.22422183
https://doi.org/10.1158/0008-5472.22422183
Autor:
Scott A. Oakes, Feroz R. Papa, Bradley J. Backes, Dustin J. Maly, Grace E. Kim, Annie Hiniker, Rachel E. Warren, Rosa Meza-Acevedo, Micah J. Gliedt, Justin Peng, Rajarshi Ghosh, Maike Thamsen, Jenny Y. Qi, Paul C. Moore
Master regulators of the unfolded protein response (UPR), IRE1α and PERK, promote adaptation or apoptosis depending on the level of endoplasmic reticulum (ER) stress. Although the UPR is activated in many cancers, its effects on tumor growth remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::679562d6e2c3b557add888ab01883cce
https://doi.org/10.1158/0008-5472.c.6511146.v1
https://doi.org/10.1158/0008-5472.c.6511146.v1
Autor:
Dustin J. Maly, John Kuriyan, Neil P. Shah, David E. Shaw, Yibing Shan, Corynn Kasap, Pratistha Ranjitkar, Markus A. Seeliger
Supplementary Table 1 from Equally Potent Inhibition of c-Src and Abl by Compounds that Recognize Inactive Kinase Conformations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0285e4fd27905ec65cfdfef8a3a7bfbe
https://doi.org/10.1158/0008-5472.22379760
https://doi.org/10.1158/0008-5472.22379760