Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Dustin E. Schones"'
Autor:
Mari B. Ishak Gabra, Ying Yang, Haiqing Li, Parijat Senapati, Eric A. Hanse, Xazmin H. Lowman, Thai Q. Tran, Lishi Zhang, Linda T. Doan, Xiangdong Xu, Dustin E. Schones, David A. Fruman, Mei Kong
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The availability of nutrients within the tumour microenvironment can influence tumour growth. Here, the authors find that, in a melanoma mouse model, mice fed a high glutamine diet have reduced tumour growth, increased sensitivity to Braf inhibitors
Externí odkaz:
https://doaj.org/article/f55f7d0478ab4cf7851235354cd349ce
Autor:
Parijat Senapati, Hiroyuki Kato, Michael Lee, Amy Leung, Christine Thai, Angelica Sanchez, Emily J. Gallagher, Derek LeRoith, Victoria L. Seewaldt, David K. Ann, Dustin E. Schones
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-15 (2019)
Abstract Background Hyperinsulinemia, the presence of excess insulin relative to glucose in the blood, is considered to be a poor prognostic indicator for patients with triple-negative breast cancer (TNBC). mTOR, a downstream effector of insulin, enh
Externí odkaz:
https://doaj.org/article/d7335b0fd4b044189496f088802659ef
Autor:
Sihui Li, Shafat Ali, Xiaotao Duan, Songbai Liu, Juan Du, Changwei Liu, Huifang Dai, Mian Zhou, Lina Zhou, Lu Yang, Peiguo Chu, Ling Li, Ravi Bhatia, Dustin E. Schones, Xiwei Wu, Hong Xu, Yuejin Hua, Zhigang Guo, Yanzhong Yang, Li Zheng, Binghui Shen
Publikováno v:
Cell Reports, Vol 23, Iss 2, Pp 389-403 (2018)
Summary: The arginine methylation status of histones dynamically changes during many cellular processes, including hematopoietic stem/progenitor cell (HSPC) development. The arginine methyltransferases and the readers that transduce the histone codes
Externí odkaz:
https://doaj.org/article/a930988b3f0b49d782e1fd6a41e25118
Autor:
Sadhan Das, Parijat Senapati, Zhuo Chen, Marpadga A. Reddy, Rituparna Ganguly, Linda Lanting, Varun Mandi, Anita Bansal, Amy Leung, Selena Zhang, Ye Jia, Xiwei Wu, Dustin E. Schones, Rama Natarajan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
The repertoire of tissue-specific distal regulators of gene transcription enhancers defines homeostasis or disease. Here, the authors reveal the enhancer and super-enhancer signature of vascular smooth muscle cells under normal and angiotensin II sti
Externí odkaz:
https://doaj.org/article/c12c799c38c64e36a32adeb8061e24ec
Vertical sleeve gastrectomy reverses diet-induced gene-regulatory changes impacting lipid metabolism
Autor:
Juan Du, Jingyan Tian, Lili Ding, Candi Trac, Brian Xia, Siming Sun, Dustin E. Schones, Wendong Huang
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Vertical sleeve gastrectomy (VSG) produces sustainable weight loss, remission of type 2 diabetes (T2D), and improvement of nonalcoholic fatty liver disease (NAFLD). However, the molecular mechanisms underlying the metabolic benefits of VSG h
Externí odkaz:
https://doaj.org/article/d0a659529ecd44d188fc16d8b8d385fd
Autor:
Nyam-Osor Chimge, Gillian H. Little, Sanjeev K. Baniwal, Helty Adisetiyo, Ying Xie, Tian Zhang, Andie O’Laughlin, Zhi Y. Liu, Peaches Ulrich, Anthony Martin, Paulette Mhawech-Fauceglia, Matthew J. Ellis, Debu Tripathy, Susan Groshen, Chengyu Liang, Zhe Li, Dustin E. Schones, Baruch Frenkel
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The tumour suppressor RUNX1 is often lost or mutated in oestrogen receptor-positive breast cancers. In this study, the authors demonstrate that the loss of RUNX1 unleashes oestrogen-mediated inhibition of AXIN1, a negative regulator of β-catenin, re
Externí odkaz:
https://doaj.org/article/29a46757716a45099f150aafec38b489
Publikováno v:
PLoS ONE, Vol 8, Iss 10 (2013)
Externí odkaz:
https://doaj.org/article/eea4cf08ce704821a8e60a9633f212ff
Autor:
Heon Shin, Amy Leung, Kevin R Costello, Parijat Senapati, Hiroyuki Kato, Roger E Moore, Michael Lee, Dimitri Lin, Xiaofang Tang, Patrick Pirrotte, Zhen Bouman Chen, Dustin E Schones
Publikováno v:
eLife, Vol 12 (2023)
The DNA methyltransferase activity of DNMT1 is vital for genomic maintenance of DNA methylation. We report here that DNMT1 function is regulated by O-GlcNAcylation, a protein modification that is sensitive to glucose levels, and that elevated O-GlcNA
Externí odkaz:
https://doaj.org/article/01fe54536d654e7bb305f7fb4ed7dac4
Autor:
Yuankun Zhang, Qingxiao Song, Kaniel Cassady, Michael Lee, Haidong Tang, Moqian Zheng, Bixin Wang, Dustin E. Schones, Yang-Xin Fu, Arthur D. Riggs, Paul J. Martin, Ru Feng, Defu Zeng
Publikováno v:
Proceedings of the National Academy of Sciences. 120
PD-L1 has two receptors: PD-1 and CD80. Previous reports assumed that PD-L1 and CD80 interacted in trans, but recent reports showed that only cis PD-L1/CD80 interactions existed, and prevention of cis PD-L1/CD80 interactions on antigen-presenting cel
Autor:
Baruch Frenkel, Dustin E. Schones, Jacek Pinski, Jeremy O. Jones, Debra Hawes, Omar Khalid, Sun Young Kim, Nyam-Osor Chimge, Susan Groshen, Helty Adisetiyo, Sanjeev K. Baniwal, Gillian H. Little
XLSX file - 9KB, Clinical characteristics of the TMA cohort.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343d930b804defb87a7530278248eb57
https://doi.org/10.1158/0008-5472.22399766
https://doi.org/10.1158/0008-5472.22399766