Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Dustin E Schones"'
Autor:
Heon Shin, Amy Leung, Kevin R Costello, Parijat Senapati, Hiroyuki Kato, Roger E Moore, Michael Lee, Dimitri Lin, Xiaofang Tang, Patrick Pirrotte, Zhen Bouman Chen, Dustin E Schones
Publikováno v:
eLife, Vol 12 (2023)
The DNA methyltransferase activity of DNMT1 is vital for genomic maintenance of DNA methylation. We report here that DNMT1 function is regulated by O-GlcNAcylation, a protein modification that is sensitive to glucose levels, and that elevated O-GlcNA
Externí odkaz:
https://doaj.org/article/01fe54536d654e7bb305f7fb4ed7dac4
Autor:
Kevin R Costello, Amy Leung, Candi Trac, Michael Lee, Mudaser Basam, J Andrew Pospisilik, Dustin E Schones
Publikováno v:
eLife, Vol 10 (2021)
Transposable elements (TEs) are mobile genetic elements that make up a large fraction of mammalian genomes. While select TEs have been co-opted in host genomes to have function, the majority of these elements are epigenetically silenced by DNA methyl
Externí odkaz:
https://doaj.org/article/55ac6a019e3446ad92dcb3e7b15bda15
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e52460 (2013)
Scanning through genomes for potential transcription factor binding sites (TFBSs) is becoming increasingly important in this post-genomic era. The position weight matrix (PWM) is the standard representation of TFBSs utilized when scanning through seq
Externí odkaz:
https://doaj.org/article/11f7857b0931488590e6249443094f9c
Autor:
Biaoyang Lin, Jun Wang, Xu Hong, Xiaowei Yan, Daehee Hwang, Ji-Hoon Cho, Danielle Yi, Angelita G Utleg, Xuefeng Fang, Dustin E Schones, Keji Zhao, Gilbert S Omenn, Leroy Hood
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6589 (2009)
BACKGROUND:The androgen receptor (AR) plays important roles in the development of male phenotype and in different human diseases including prostate cancers. The AR can act either as a promoter or a tumor suppressor depending on cell types. The AR pro
Externí odkaz:
https://doaj.org/article/3a2c9779014345f6aa120a297858c747
Autor:
Mari B. Ishak Gabra, Ying Yang, Haiqing Li, Parijat Senapati, Eric A. Hanse, Xazmin H. Lowman, Thai Q. Tran, Lishi Zhang, Linda T. Doan, Xiangdong Xu, Dustin E. Schones, David A. Fruman, Mei Kong
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The availability of nutrients within the tumour microenvironment can influence tumour growth. Here, the authors find that, in a melanoma mouse model, mice fed a high glutamine diet have reduced tumour growth, increased sensitivity to Braf inhibitors
Externí odkaz:
https://doaj.org/article/f55f7d0478ab4cf7851235354cd349ce
Autor:
David A. Skaar, Eric C. Dietze, Jackelyn A. Alva-Ornelas, David Ann, Dustin E. Schones, Terry Hyslop, Christopher Sistrunk, Carola Zalles, Adrian Ambrose, Kendall Kennedy, Ombeni Idassi, Gustavo Miranda Carboni, Michael N. Gould, Randy L. Jirtle, Victoria L. Seewaldt
Publikováno v:
Cancers, Vol 13, Iss 23, p 6031 (2021)
Genomic imprinting is an inherited form of parent-of-origin specific epigenetic gene regulation that is dysregulated by poor prenatal nutrition and environmental toxins. KCNK9 encodes for TASK3, a pH-regulated potassium channel membrane protein that
Externí odkaz:
https://doaj.org/article/9e2898cfe24c47d2a1bbe86b8234d8d3
Autor:
Sadhan Das, Parijat Senapati, Zhuo Chen, Marpadga A. Reddy, Rituparna Ganguly, Linda Lanting, Varun Mandi, Anita Bansal, Amy Leung, Selena Zhang, Ye Jia, Xiwei Wu, Dustin E. Schones, Rama Natarajan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
The repertoire of tissue-specific distal regulators of gene transcription enhancers defines homeostasis or disease. Here, the authors reveal the enhancer and super-enhancer signature of vascular smooth muscle cells under normal and angiotensin II sti
Externí odkaz:
https://doaj.org/article/c12c799c38c64e36a32adeb8061e24ec
Autor:
Yuankun Zhang, Qingxiao Song, Kaniel Cassady, Michael Lee, Haidong Tang, Moqian Zheng, Bixin Wang, Dustin E. Schones, Yang-Xin Fu, Arthur D. Riggs, Paul J. Martin, Ru Feng, Defu Zeng
Publikováno v:
Proceedings of the National Academy of Sciences. 120
PD-L1 has two receptors: PD-1 and CD80. Previous reports assumed that PD-L1 and CD80 interacted in trans, but recent reports showed that only cis PD-L1/CD80 interactions existed, and prevention of cis PD-L1/CD80 interactions on antigen-presenting cel
Autor:
Baruch Frenkel, Dustin E. Schones, Jacek Pinski, Jeremy O. Jones, Debra Hawes, Omar Khalid, Sun Young Kim, Nyam-Osor Chimge, Susan Groshen, Helty Adisetiyo, Sanjeev K. Baniwal, Gillian H. Little
XLSX file - 9KB, Clinical characteristics of the TMA cohort.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343d930b804defb87a7530278248eb57
https://doi.org/10.1158/0008-5472.22399766
https://doi.org/10.1158/0008-5472.22399766
Autor:
Baruch Frenkel, Dustin E. Schones, Jacek Pinski, Jeremy O. Jones, Debra Hawes, Omar Khalid, Sun Young Kim, Nyam-Osor Chimge, Susan Groshen, Helty Adisetiyo, Sanjeev K. Baniwal, Gillian H. Little
XLSX file - 13KB, Association between AR, RUNX2 and SNAI2 in clinical samples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b4510f224cb1446f9149c9e560c74b
https://doi.org/10.1158/0008-5472.22399751
https://doi.org/10.1158/0008-5472.22399751