Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Dustin A. Bringley"'
Autor:
Barry M. Trost, Dustin A. Bringley
Publikováno v:
Angewandte Chemie International Edition. 52:4466-4469
An approach to 2,2-disubstituted 4-methylenetetrahydrofurans has been developed utilizing a cycloaddition of trimethylenemethane with aryl ketones, with formation of the products in up to 96% yield and 95% ee. The reaction is catalyzed by palladium i
Enantioselective Palladium-Catalyzed [3 + 2] Cycloadditions of Trimethylenemethane with Nitroalkenes
Publikováno v:
Organic Letters. 14:234-237
Nitroalkenes readily undergo palladium-catalyzed [3 + 2] cycloaddition with trimethylenemethane to generate nitrocyclopentanes in excellent yield and enantioselectivity. Furthermore, the products thus formed are highly versatile synthetic intermediat
Publikováno v:
Journal of the American Chemical Society. 133:7664-7667
The palladium-catalyzed [3 + 2] cycloaddition of trimethylenemethane (TMM) with aldehydes is a direct and efficient route to methylenetetrahydrofurans. Herein we describe the first asymmetric synthesis of methylenetetrahydrofurans utilizing a palladi
Publikováno v:
ChemInform. 46
The title reaction proceeds without subsequent rearomatization and can be applied on a broad range of heterocyclic and benzoid substrates.
Publikováno v:
Journal of the American Chemical Society. 136(23)
A general protocol for the palladium-catalyzed dearomative trimethylenemethane [3+2] cycloaddition reaction with simple nitroarene substrates is described. This methodology leads to the exclusive formation of the dearomatized alicyclic products witho
Publikováno v:
ChemInform. 45
The title reaction provides a synthesis of marcofortines, which are potent anthelmintic active metabolites.
Publikováno v:
ChemInform. 45
β-Disubstituted nitroalkenes readily undergo palladium-catalyzed [3 + 2] cycloaddition with trimethylenemethane to generate nitrocyclopentanes in excellent yield and enantioselectivity.
Publikováno v:
Organic letters. 15(22)
β,β-Disubstituted nitroalkenes readily undergo palladium-catalyzed [3 + 2] cycloaddition with trimethylenemethane to generate nitrocyclopentanes in excellent yield and enantioselectivity. The reaction provides access to heavily substituted cyclopen
Publikováno v:
Journal of the American Chemical Society. 135(44)
The marcfortines are complex secondary metabolites that show potent anthelmintic activity and are characterized by the presence of a bicyclo[2.2.2]diazaoctane fused to a spirooxindole. Herein, we report the synthesis of two members of this family. Th
Autor:
Dustin A. Bringley, Barry M. Trost
Publikováno v:
ChemInform. 44
The presented reaction demonstrates novel reactivity and provides the title compounds bearing a tetrasubstituted stereocenter.