Zobrazeno 1 - 10
of 529
pro vyhledávání: '"Dustin, Ml"'
Publikováno v:
Trends Neurosci
The blood-brain barrier (BBB) continues to represent one of the most significant challenges for successful drug-based treatments of neurological disease. Mechanical modulation of the BBB using focused ultrasound (FUS) and microbubbles (MBs) has shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::040f864a0ff6c56e7ccc2376b8e9689c
https://doi.org/10.1016/j.tins.2022.03.003
https://doi.org/10.1016/j.tins.2022.03.003
Autor:
Sfeir, A, Fishell, G, Schier, AF, Dustin, ML, Gan, W-B, Joyner, A, Lehmann, R, Ron, D, Roth, D, Talbot, WS, Yelon, D, Zychlinsky, A
Publikováno v:
Cell. 185:755-758
Support for basic science has been eclipsed by initiatives aimed at specific medical problems. The latest example is the dismantling of the Skirball Institute at NYU School of Medicine. Here, we reflect on the achievements and mission underlying the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cbac894424dfa51b7cf5378b042e9aa
https://doi.org/10.1016/j.cell.2022.02.008
https://doi.org/10.1016/j.cell.2022.02.008
T follicular helper (TFH) cells promote expansion of germinal center (GC) B cells and plasma cell differentiation. Whether cognate peptide-MHCII (pMHCII) density instructs selection and cell fate decisions in a quantitative manner remains unclear. Us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436a64888b0417017481c255e6244031
https://doi.org/10.1016/j.celrep.2022.110763
https://doi.org/10.1016/j.celrep.2022.110763
Autor:
Céspedes, PF, Dustin, ML
Publikováno v:
Journal of Visualized Experiments.
Antigen-presenting cells (APCs) present three activating signals to T cells engaged in physical contact: 1) antigen, 2) costimulation/corepression, and 3) soluble cytokines. T cells release two kinds of effector particles in response to activation: t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e470589357235755f3401c40c510de
https://doi.org/10.3791/63130-v
https://doi.org/10.3791/63130-v
Autor:
Jainarayanan, AK, Anand, NM, Arbe-Barnes, EH, Bashford-Rogers, R, Abu-Shah, E, Dustin, ML, Sivakumar, S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1064::36ca1b6151973d05641f6b2e501460c3
https://ora.ox.ac.uk/objects/uuid:8db88495-ff19-40d5-8bcb-8845b3356ca6
https://ora.ox.ac.uk/objects/uuid:8db88495-ff19-40d5-8bcb-8845b3356ca6
The interplay between membrane topology and mechanical forces in regulating T cell receptor activity
Publikováno v:
Communications Biology
Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)
Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)
T cells are critically important for host defense against infections. T cell activation is specific because signal initiation requires T cell receptor (TCR) recognition of foreign antigen peptides presented by major histocompatibility complexes (pMHC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ca110cd3d56d10e5884233f63bd1a3
https://doi.org/10.1038/s42003-021-02995-1
https://doi.org/10.1038/s42003-021-02995-1
Autor:
Dustin, ML
Publikováno v:
Journal of Cell Biology. 220
Hematopoietic stem and progenitor cells (HSPCs) use specialized adhesive structures referred to as magnupodium to stay in hematopoietic niches. Bessey et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202005085) define new characteristics of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b29e225285cd6d0c5b92c29816c89d
https://doi.org/10.1083/jcb.202109019
https://doi.org/10.1083/jcb.202109019
Autor:
Lanz, A-L, Masi, G, Porciello, N, Cohnen, A, Cipria, D, Prakaash, D, Bálint, Š, Raggiaschi, R, Galgano, D, Cole, DK, Lepore, M, Dushek, O, Dustin, ML, Sansom, MSP, Kalli, AC, Acuto, O
The mechanism of T cell antigen receptor (TCR-CD3) signaling remains elusive. Here, we identify mutations in the transmembrane region of TCRβ or CD3ζ that augment peptide T cell antigen receptor (pMHC)-induced signaling not explicable by enhanced l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::9e007c1516b18e255258b729d06cc430
https://eprints.whiterose.ac.uk/176171/1/1-s2.0-S2211124721007737-main.pdf
https://eprints.whiterose.ac.uk/176171/1/1-s2.0-S2211124721007737-main.pdf
Autor:
Xie, B, Khoyratty, ET, Abu-Shah, E, Cespedes, P, MacLean, AJ, Pirgova, G, Dustin, ML, Udalova, IA, Hu, Z, Ahmed, AA, Arnon, TI
The PI3K pathway plays a key role in B cell activation and is important for the differentiation of Ab producing plasma cells (PCs). Although much is known about the molecular mechanisms that modulate PI3K signaling in B cells, the transcriptional reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1064::3cd738d176014b8b76545fab03f8e9f5
https://ora.ox.ac.uk/objects/uuid:3d94fc95-52bc-44b8-abd1-30130e73772d
https://ora.ox.ac.uk/objects/uuid:3d94fc95-52bc-44b8-abd1-30130e73772d