TCR/CD3-based synthetic antigen receptors (TCC) convey superior antigen sensitivity combined with high fidelity of activation.

Autor: Mühlgrabner V; Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Institute for Hygiene and Applied Immunology, Vienna, Austria., Peters T; Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Institute for Hygiene and Applied Immunology, Vienna, Austria., Velasco Cárdenas RM; Department of Immunology, Faculty of Biology, University of Freiburg, Germany.; Center for Biological Signaling Studies (BIOSS), University of Freiburg, Germany.; Center for Integrative Biological Signaling Studies (CIBSS), University of Freiburg, Germany., Salzer B; St. Anna Children's Cancer Research Institute (CCRI), 1090, Vienna, Austria.; Christian Doppler Laboratory for Next Generation CAR T Cells, 1090, Vienna, Austria., Göhring J; Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Institute for Hygiene and Applied Immunology, Vienna, Austria., Plach A; Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Institute for Hygiene and Applied Immunology, Vienna, Austria., Höhrhan M; Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Institute for Hygiene and Applied Immunology, Vienna, Austria., Perez ID; Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Institute for Hygiene and Applied Immunology, Vienna, Austria., Goncalves VDR; Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany., Farfán JS; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK., Lehner M; St. Anna Children's Cancer Research Institute (CCRI), 1090, Vienna, Austria.; Christian Doppler Laboratory for Next Generation CAR T Cells, 1090, Vienna, Austria., Stockinger H; Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Institute for Hygiene and Applied Immunology, Vienna, Austria., Schamel WW; Department of Immunology, Faculty of Biology, University of Freiburg, Germany.; Center for Biological Signaling Studies (BIOSS), University of Freiburg, Germany.; Center for Integrative Biological Signaling Studies (CIBSS), University of Freiburg, Germany., Schober K; Mikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Busch DH; Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany., Hudecek M; Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany., Dushek O; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK., Minguet S; Department of Immunology, Faculty of Biology, University of Freiburg, Germany.; Center for Biological Signaling Studies (BIOSS), University of Freiburg, Germany.; Center for Integrative Biological Signaling Studies (CIBSS), University of Freiburg, Germany., Platzer R; Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Institute for Hygiene and Applied Immunology, Vienna, Austria., Huppa JB; Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Institute for Hygiene and Applied Immunology, Vienna, Austria.

Publikováno v: Science advances [Sci Adv] 2024 Sep 06; Vol. 10 (36), pp. eadj4632. Date of Electronic Publication: 2024 Sep 04.

A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity.

Autor: Liu C; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Zhou D; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, Centre for Human Genetics, Oxford, UK., Dijokaite-Guraliuc A; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Supasa P; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK., Duyvesteyn HME; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, Centre for Human Genetics, Oxford, UK., Ginn HM; Centre for Free Electron Laser Science, Hamburg, Germany., Selvaraj M; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK., Mentzer AJ; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Das R; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK., de Silva TI; Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK., Ritter TG; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Plowright M; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK., Newman TAH; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK., Stafford L; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Kronsteiner B; NDM Centre for Global Health Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK., Temperton N; Viral Pseudotype Unit, Medway School of Pharmacy, University of Kent and University of Greenwich Chatham Maritime, Kent ME4 4TB, UK., Lui Y; Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK., Fellermeyer M; Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK., Goulder P; Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK; Department of Paediatrics, University of Oxford, Oxford, UK., Klenerman P; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Dunachie SJ; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK; NDM Centre for Global Health Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand., Barton MI; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK., Kutuzov MA; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK., Dushek O; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK., Fry EE; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, Centre for Human Genetics, Oxford, UK. Electronic address: liz@strubi.ox.ac.uk., Mongkolsapaya J; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand. Electronic address: juthathip.mongkolsapaya@well.ox.ac.uk., Ren J; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, Centre for Human Genetics, Oxford, UK. Electronic address: ren@strubi.ox.ac.uk., Stuart DI; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, Centre for Human Genetics, Oxford, UK; Sir William Dunn School of Pathology, Oxford, UK. Electronic address: dave@strubi.ox.ac.uk., Screaton GR; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK. Electronic address: gavin.screaton@medsci.ox.ac.uk.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2024 May 21; Vol. 5 (5), pp. 101553. Date of Electronic Publication: 2024 May 08.

Tuning the potency and selectivity of ImmTAC molecules by affinity modulation.

Autor: Robertson IB; Immunocore Limited, Drug Discovery and Protein Engineering, Abingdon, Oxon, UK., Mulvaney R; Immunocore Limited, Drug Discovery and Protein Engineering, Abingdon, Oxon, UK., Dieckmann N; Immunocore Limited, Drug Discovery and Protein Engineering, Abingdon, Oxon, UK., Vantellini A; Immunocore Limited, Drug Discovery and Protein Engineering, Abingdon, Oxon, UK., Canestraro M; Immunocore Limited, Drug Discovery and Protein Engineering, Abingdon, Oxon, UK., Amicarella F; Immunocore Limited, Drug Discovery and Protein Engineering, Abingdon, Oxon, UK., O'Dwyer R; Immunocore Limited, Drug Discovery and Protein Engineering, Abingdon, Oxon, UK., Cole DK; Immunocore Limited, Drug Discovery and Protein Engineering, Abingdon, Oxon, UK., Harper S; Immunocore Limited, Drug Discovery and Protein Engineering, Abingdon, Oxon, UK., Dushek O; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK., Kirk P; Immunocore Limited, Drug Discovery and Protein Engineering, Abingdon, Oxon, UK.

Publikováno v: Clinical and experimental immunology [Clin Exp Immunol] 2024 Feb 07; Vol. 215 (2), pp. 105-119.

Using CombiCells, a platform for titration and combinatorial display of cell surface ligands, to study T-cell antigen sensitivity modulation by accessory receptors.

Autor: Patel A; Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK., Andre V; Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK., Eguiguren SB; Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK., Barton MI; Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK., Burton J; Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK., Denham EM; Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK.; EnaraBio Ltd, The Bellhouse Building, Oxford Science Park, Sanders Road, Oxford, OX44GD, UK., Pettmann J; Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK.; GlaxoSmithKline Pharmaceuticals, Rue de l'Institut 89, 1330, Rixensart, Belgium., Mørch AM; The Kennedy Institute of Rheumatology, University of Oxford, Oxford, OX3 7FY, UK., Kutuzov MA; Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK., Siller-Farfán JA; Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK., Dustin ML; The Kennedy Institute of Rheumatology, University of Oxford, Oxford, OX3 7FY, UK., van der Merwe PA; Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK., Dushek O; Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK. omer.dushek@path.ox.ac.uk.

Publikováno v: The EMBO journal [EMBO J] 2024 Jan; Vol. 43 (1), pp. 132-150. Date of Electronic Publication: 2023 Dec 18.

Fluctuations in T cell receptor and pMHC interactions regulate T cell activation

Autor: Egan, JR, Abu-Shah, E, Dushek, O, Elliott, T, MacArthur, BD

Adaptive immune responses depend on interactions between T cell receptors (TCRs) and peptide major histocompatibility complex (pMHC) ligands located on the surface of T cells and antigen presenting cells (APCs), respectively. As TCRs and pMHCs are of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4581b7681c6f33df8372a41e4501ce92
https://eprints.soton.ac.uk/470260/