Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Dushanthi Pinnaduwage"'
Autor:
Jay S. Wunder, Minji J. Lee, Junghyun Nam, Beatrice Y. Lau, Brendan C. Dickson, Dushanthi Pinnaduwage, Shelley B. Bull, Peter C. Ferguson, Andrew Seto, Nalan Gokgoz, Irene L. Andrulis
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Immune checkpoint proteins, such as PD-L1 and PD-1, are important in several cancers; however, their role in osteosarcoma (OSA) and soft tissue sarcoma (STS) remains unclear. Our aims were to determine whether subsets of OSA/STS harbor tumor-infiltra
Externí odkaz:
https://doaj.org/article/0026928f059a4331a52a64db61b3b10a
Autor:
Minji Lee, Farnoosh Tayyari, Dushanthi Pinnaduwage, Jane Bayani, John M. S. Bartlett, Anna Marie Mulligan, Shelley B. Bull, Irene L. Andrulis
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-11 (2018)
Abstract Background We previously observed that T-bet+ tumor-infiltrating T lymphocytes (T-bet+ TILs) in primary breast tumors were associated with adverse clinicopathological features, yet favorable clinical outcome. We identified BRD4 (Bromodomain-
Externí odkaz:
https://doaj.org/article/64c91a0a72244a259428234fbe8ac269
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 10, Pp 797-800 (2007)
There is a growing body of evidence implicating aberrant circadian clock expression in the development of cancer. Based on our initial experiments identifying a putative interaction between BRCA1, the clock proteins Per1, Per2, as well as the reporte
Externí odkaz:
https://doaj.org/article/8ae23cc9e79b4180991afc15b56d4b97
Publikováno v:
Sarcoma, Vol 2014 (2014)
Despite the importance of Hedgehog signaling in bone development, the relationship between Hedgehog pathway expression and osteosarcoma clinical characteristics and outcome has not been investigated. In this study of 43 high-grade human osteosarcoma
Externí odkaz:
https://doaj.org/article/f95a6593974148679376f299774865d7
Autor:
Irene L. Andrulis, Shelley B. Bull, Sandrine Tchatchou, Dushanthi Pinnaduwage, Anna Marie Mulligan
We previously observed T-bet+ lymphocytes to be associated with a good prognosis in a cohort of women with familial breast cancer. To validate this finding, we evaluated lymphocyte T-bet expression in an independent unselected prospectively accrued s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc6578dd7afd0745b99d9cd1932a6c43
https://doi.org/10.1158/2326-6066.c.6548386.v1
https://doi.org/10.1158/2326-6066.c.6548386.v1
Autor:
Irene L. Andrulis, Shelley B. Bull, Sandrine Tchatchou, Dushanthi Pinnaduwage, Anna Marie Mulligan
Table S1 gives the relative risks by univariate Cox proportional hazards model of DFS for di- categorization (low, high) of T-bet for several (10, 15, 20, 25, 30) cut points. T-bet-/low was associated with reduced DFS at cut points 15, 25, and 30 as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ad007b368b7da7099f64f034b344fe
https://doi.org/10.1158/2326-6066.22537297
https://doi.org/10.1158/2326-6066.22537297
Autor:
Irene L. Andrulis, Shelley B. Bull, Sandrine Tchatchou, Dushanthi Pinnaduwage, Anna Marie Mulligan
This figure compares K-M curves of DFS by di- and tri- categorizations of T-bet for several (10, 15, 20, 25,) cut points. It is evident in the three-level KM plots that the absent and low count groups of T-bet are indistinguishable for the cut-points
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::134f69bbbc383ae56f4f12ede19aad6c
https://doi.org/10.1158/2326-6066.22537300
https://doi.org/10.1158/2326-6066.22537300
Autor:
Irene L. Andrulis, Pamela S. Ohashi, Frances P. O'Malley, Linh T. Nguyen, Dushanthi Pinnaduwage, Linda Feeley, Irene Raitman, Anna Marie Mulligan
PDF file - 7284K, Supplementary Figure S1: (A) Representative CXCL10 stained TMA (x1.25). (B) Invasive carcinoma showing absence of tumoral CXCL10 expression (x20). (C) Low tumoral CXCL10 expression (x20). (D-E) Moderate and high tumoral CXCL10 expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00127663eac938267575a6be2f9e1089
https://doi.org/10.1158/1078-0432.22456226
https://doi.org/10.1158/1078-0432.22456226
Autor:
Irene L. Andrulis, Pamela S. Ohashi, Frances P. O'Malley, Linh T. Nguyen, Dushanthi Pinnaduwage, Linda Feeley, Irene Raitman, Anna Marie Mulligan
PDF file - 10654K, Supplementary Figure S2: (A) Representative CD4 stained TMA (x1.25). (B) Invasive carcinoma showing absence of intratumoral CD4+ lymphocytes (x20). (C-D) Intratumoral CD4+ lymphocytes (x20, x40, respectively). (E-F) Peritumoral CD4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::871855da2aa7cf005ceab97f980f43ed
https://doi.org/10.1158/1078-0432.22456223
https://doi.org/10.1158/1078-0432.22456223
Autor:
Irene L. Andrulis, Pamela S. Ohashi, Frances P. O'Malley, Linh T. Nguyen, Dushanthi Pinnaduwage, Linda Feeley, Irene Raitman, Anna Marie Mulligan
PDF file - 104K, Table S1. Summary of antibodies and conditions of use Table S2. Pathologic Characteristics of the Breast Tumors Table S3. Association between CXCL10 and CD4 and CD8 peritumoral expression Table S4. (A) Association between FOXP3 and M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1a4428087983f059d47dfe69e1ac272
https://doi.org/10.1158/1078-0432.22456211.v1
https://doi.org/10.1158/1078-0432.22456211.v1