Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Dusanka, Milenkovic"'
Autor:
Dusanka Milenkovic, Adrián Sanz-Moreno, Julia Calzada-Wack, Birgit Rathkolb, Oana Veronica Amarie, Raffaele Gerlini, Antonio Aguilar-Pimentel, Jelena Misic, Marie-Lune Simard, Eckhard Wolf, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabě de Angelis, Nils-Göran Larsson
Publikováno v:
PLoS Genetics, Vol 18, Iss 5, p e1010190 (2022)
Mitochondrial DNA (mtDNA) maintenance disorders are caused by mutations in ubiquitously expressed nuclear genes and lead to syndromes with variable disease severity and tissue-specific phenotypes. Loss of function mutations in the gene encoding the m
Externí odkaz:
https://doaj.org/article/5717622e5f364704b033f7ed9effe976
Autor:
Swaraj Basu, Xie Xie, Jay P Uhler, Carola Hedberg-Oldfors, Dusanka Milenkovic, Olivier R Baris, Sammy Kimoloi, Stanka Matic, James B Stewart, Nils-Göran Larsson, Rudolf J Wiesner, Anders Oldfors, Claes M Gustafsson, Maria Falkenberg, Erik Larsson
Publikováno v:
PLoS Genetics, Vol 16, Iss 12, p e1009242 (2020)
Deletions and duplications in mitochondrial DNA (mtDNA) cause mitochondrial disease and accumulate in conditions such as cancer and age-related disorders, but validated high-throughput methodology that can readily detect and discriminate between thes
Externí odkaz:
https://doaj.org/article/b37608b27ed04fa5a6f640ac89a4920d
Autor:
Kara L. Perks, Giulia Rossetti, Irina Kuznetsova, Laetitia A. Hughes, Judith A. Ermer, Nicola Ferreira, Jakob D. Busch, Danielle L. Rudler, Henrik Spahr, Thomas Schöndorf, Ann-Marie J. Shearwood, Helena M. Viola, Stefan J. Siira, Livia C. Hool, Dusanka Milenkovic, Nils-Göran Larsson, Oliver Rackham, Aleksandra Filipovska
Publikováno v:
Cell Reports, Vol 23, Iss 1, Pp 127-142 (2018)
Summary: The regulation of mitochondrial RNA life cycles and their roles in ribosome biogenesis and energy metabolism are not fully understood. We used CRISPR/Cas9 to generate heart- and skeletal-muscle-specific knockout mice of the pentatricopeptide
Externí odkaz:
https://doaj.org/article/8dbb75c8694646508ff8f39a311f3b3c
Autor:
Stanka Matic, Min Jiang, Thomas J. Nicholls, Jay P. Uhler, Caren Dirksen-Schwanenland, Paola Loguercio Polosa, Marie-Lune Simard, Xinping Li, Ilian Atanassov, Oliver Rackham, Aleksandra Filipovska, James B. Stewart, Maria Falkenberg, Nils-Göran Larsson, Dusanka Milenkovic
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
It has been debated whether premature ageing in mitochondrial DNA mutator mice is driven by point mutations or deletions of mtDNA. Matic et al generate Mgme1 knockout mice and show here that these mice have tissue-specific replication stalling and ac
Externí odkaz:
https://doaj.org/article/e4875b41d2804c3a99656ff7ae1c7aca
Autor:
Jelena Misic, Dusanka Milenkovic, Ali Al-Behadili, Xie Xie, Min Jiang, Shan Jiang, Roberta Filograna, Camilla Koolmeister, Stefan J Siira, Louise Jenninger, Aleksandra Filipovska, Anders R Clausen, Leonardo Caporali, Maria Lucia Valentino, Chiara La Morgia, Valerio Carelli, Thomas J Nicholls, Anna Wredenberg, Maria Falkenberg, Nils-Göran Larsson
Publikováno v:
Nucleic Acids Res
The in vivo role for RNase H1 in mammalian mitochondria has been much debated. Loss of RNase H1 is embryonic lethal and to further study its role in mtDNA expression we characterized a conditional knockout of Rnaseh1 in mouse heart. We report that RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dcd16c7d756754674095ebb51a588ff
https://doi.org/10.1093/nar/gkac661
https://doi.org/10.1093/nar/gkac661
Autor:
Jakob D. Busch, Miriam Cipullo, Ilian Atanassov, Ana Bratic, Eduardo Silva Ramos, Thomas Schöndorf, Xinping Li, Sarah F. Pearce, Dusanka Milenkovic, Joanna Rorbach, Nils-Göran Larsson
Publikováno v:
Cell Reports, Vol 29, Iss 6, Pp 1728-1738.e9 (2019)
Summary: Mitochondria harbor specialized ribosomes (mitoribosomes) necessary for the synthesis of key membrane proteins of the oxidative phosphorylation (OXPHOS) machinery located in the mitochondrial inner membrane. To date, no animal model exists t
Externí odkaz:
https://doaj.org/article/47fa904e13314d7a923559092c3f94f1
Autor:
Oliver Rackham, Jakob D. Busch, Stanka Matic, Stefan J. Siira, Irina Kuznetsova, Ilian Atanassov, Judith A. Ermer, Anne-Marie J. Shearwood, Tara R. Richman, James B. Stewart, Arnaud Mourier, Dusanka Milenkovic, Nils-Göran Larsson, Aleksandra Filipovska
Publikováno v:
Cell Reports, Vol 16, Iss 7, Pp 1874-1890 (2016)
The regulation of mitochondrial RNA processing and its importance for ribosome biogenesis and energy metabolism are not clear. We generated conditional knockout mice of the endoribonuclease component of the RNase P complex, MRPP3, and report that it
Externí odkaz:
https://doaj.org/article/652a730d45964cd69e2050754ec12432
Autor:
Rafael Pérez-Pérez, Teresa Lobo-Jarne, Dusanka Milenkovic, Arnaud Mourier, Ana Bratic, Alberto García-Bartolomé, Erika Fernández-Vizarra, Susana Cadenas, Aitor Delmiro, Inés García-Consuegra, Joaquín Arenas, Miguel A. Martín, Nils-Göran Larsson, Cristina Ugalde
Publikováno v:
Cell Reports, Vol 16, Iss 9, Pp 2387-2398 (2016)
Mitochondrial respiratory chain (MRC) complexes I, III, and IV associate into a variety of supramolecular structures known as supercomplexes and respirasomes. While COX7A2L was originally described as a supercomplex-specific factor responsible for th
Externí odkaz:
https://doaj.org/article/57f6b2a6d31a4e268acc95b07dda5358
Autor:
Jelena Misic, Dusanka Milenkovic
Publikováno v:
Methods in Molecular Biology ISBN: 9781071629215
Mitochondrial DNA: Methods in Molecular Biology
Mitochondrial DNA: Methods in Molecular Biology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55cf0fe812826197d9da7dab06fe5aa5
https://doi.org/10.1007/978-1-0716-2922-2_16
https://doi.org/10.1007/978-1-0716-2922-2_16
Autor:
Natalie C. Ward, Maike Stentenbach, Nicola Gray, Helena M. Viola, Satoru Takahashi, Giulia Rossetti, Emma Jamieson, Kara L. Perks, Judith A. Ermer, Tara R. Richman, Gulibaikelamu Xiafukaiti, Oliver Rackham, Dusanka Milenkovic, Livia C. Hool, Stefan J. Siira, Aleksandra Filipovska, Laetitia A. Hughes
Publikováno v:
Science Advances
Sci Adv
Sci Adv
Description
A variant in an RNA processing enzyme predisposes to insulin resistance by reducing calcium release and insulin secretion.
Mitochondrial energy metabolism plays an important role in the pathophysiology of insulin resistance. Rec
A variant in an RNA processing enzyme predisposes to insulin resistance by reducing calcium release and insulin secretion.
Mitochondrial energy metabolism plays an important role in the pathophysiology of insulin resistance. Rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e330f967935ade9f4cec211c584ef3b8
http://europepmc.org/articles/PMC8462889
http://europepmc.org/articles/PMC8462889