Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Dusan Hesek"'
Autor:
Siseth Martínez-Caballero, Céline Freton, Rafael Molina, Sergio G. Bartual, Virginie Gueguen-Chaignon, Chryslène Mercy, Federico Gago, Kiran V. Mahasenan, Inés G. Muñoz, Mijoon Lee, Dusan Hesek, Shahriar Mobashery, Juan A. Hermoso, Christophe Grangeasse
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112756- (2023)
Summary: Bacterial cell-wall hydrolases must be tightly regulated during bacterial cell division to prevent aberrant cell lysis and to allow final separation of viable daughter cells. In a multidisciplinary work, we disclose the molecular dialogue be
Externí odkaz:
https://doaj.org/article/d81c8fc5e2aa4f5d9ff7f86ec5f0dc25
Autor:
Siseth Martínez-Caballero, Kiran V. Mahasenan, Choon Kim, Rafael Molina, Rhona Feltzer, Mijoon Lee, Renee Bouley, Dusan Hesek, Jed F. Fisher, Inés G. Muñoz, Mayland Chang, Shahriar Mobashery, Juan A. Hermoso
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 5392-5405 (2021)
The penicillin-binding proteins are the enzyme catalysts of the critical transpeptidation crosslinking polymerization reaction of bacterial peptidoglycan synthesis and the molecular targets of the penicillin antibiotics. Here, we report a combined cr
Externí odkaz:
https://doaj.org/article/0af59740be1241078a1417fa0b394874
Autor:
Kyungjin Min, Doo Ri An, Hye-Jin Yoon, Neha Rana, Ji Su Park, Jinshil Kim, Mijoon Lee, Dusan Hesek, Sangryeol Ryu, B. Moon Kim, Shahriar Mobashery, Se Won Suh, Hyung Ho Lee
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Peptidoglycans (PG) define bacterial cell shapes. Here, the authors provide mechanistic insights into the peptidoglycan peptidase 3 (Pgp3) from the spiral shaped human pathogen Campylobacter jejuni by determining its crystal structure alone and in co
Externí odkaz:
https://doaj.org/article/13c1a77948d7413ba83fdcf089e8a278
Autor:
Martín Alcorlo, David A. Dik, Stefania De Benedetti, Kiran V. Mahasenan, Mijoon Lee, Teresa Domínguez-Gil, Dusan Hesek, Elena Lastochkin, Daniel López, Bill Boggess, Shahriar Mobashery, Juan A. Hermoso
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
SPOR domains are present in bacterial proteins that recognize cell-wall peptidoglycan strands stripped of the peptide stems. Here, Alcorlo et al. show that, indeed, the presence of peptide stems abrogates binding to a SPOR domain, and provide insight
Externí odkaz:
https://doaj.org/article/120e67d6e4b84738995cb033a43e838a
Autor:
Thomas E. Smith, Mijoon Lee, Maria D. Person, Dusan Hesek, Shahriar Mobashery, Nancy A. Moran
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT During evolution, enzymes can undergo shifts in preferred substrates or in catalytic activities. An intriguing question is how enzyme function changes following horizontal gene transfer, especially for bacterial genes that have moved to anim
Externí odkaz:
https://doaj.org/article/6e00fba6110c413aad4670c24256bc40
Autor:
Doo Ri An, Ha Na Im, Jun Young Jang, Hyoun Sook Kim, Jieun Kim, Hye Jin Yoon, Dusan Hesek, Mijoon Lee, Shahriar Mobashery, Soon-Jong Kim, Se Won Suh
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164243 (2016)
Colonization of the human gastric mucosa by Helicobacter pylori requires its high motility, which depends on the helical cell shape. In H. pylori, several genes (csd1, csd2, csd3/hdpA, ccmA, csd4, csd5, and csd6) play key roles in determining the cel
Externí odkaz:
https://doaj.org/article/8dfa46992680421299a4958c6cde9aef
Autor:
Obolbek Turapov, Jessica Loraine, Christopher H. Jenkins, Philippe Barthe, Daniel McFeely, Francesca Forti, Daniela Ghisotti, Dusan Hesek, Mijoon Lee, Andrew R. Bottrill, Waldemar Vollmer, Shahriar Mobashery, Martin Cohen-Gonsaud, Galina V. Mukamolova
Publikováno v:
Open Biology, Vol 5, Iss 7 (2015)
PknB is an essential serine/threonine protein kinase required for mycobacterial cell division and cell-wall biosynthesis. Here we demonstrate that overexpression of the external PknB_PASTA domain in mycobacteria results in delayed regrowth, accumulat
Externí odkaz:
https://doaj.org/article/769d10a9bca946cdb71d9703183953f2
Autor:
Peter Mellroth, Tatyana Sandalova, Alexey Kikhney, Francisco Vilaplana, Dusan Hesek, Mijoon Lee, Shahriar Mobashery, Staffan Normark, Dmitri Svergun, Birgitta Henriques-Normark, Adnane Achour
Publikováno v:
mBio, Vol 5, Iss 1 (2014)
ABSTRACT The cytosolic N-acetylmuramoyl-l-alanine amidase LytA protein of Streptococcus pneumoniae, which is released by bacterial lysis, associates with the cell wall via its choline-binding motif. During exponential growth, LytA accesses its peptid
Externí odkaz:
https://doaj.org/article/7bbf23dded394841b27d52760a315892
Publikováno v:
ChemBioChem.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e13b3ff13e934b419b3154099a9bb72d
https://doi.org/10.1002/cbic.202300282
https://doi.org/10.1002/cbic.202300282
Autor:
Mijoon Lee, Shahriar Mobashery, Dusan Hesek, Focco van den Akker, Jacob Boorman, Elena Lastochkin, Ximin Zeng, Jun Lin, Snigdha A. Mathure, Vijay Kumar
Publikováno v:
Biochemistry. 60:1133-1144
The soluble lytic transglycosylase Cj0843c from Campylobacter jejuni breaks down cell-wall peptidoglycan (PG). Its nonhydrolytic activity sustains cell-wall remodeling and repair. We report herein our structure-function studies probing the substrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::455a0d027b19aa8954e9241d16bcc51e
https://doi.org/10.1021/acs.biochem.1c00027
https://doi.org/10.1021/acs.biochem.1c00027