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pro vyhledávání: '"Durrant DE"'
RAF kinases are essential effectors of RAS, but how RAS binding initiates the conformational changes needed for autoinhibited RAF monomers to form active dimers has remained unclear. Here, we present cryo-electron microscopy structures of full-length
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::978295844125dd126c6ad25d652f715f
https://doi.org/10.1101/2021.09.30.462573
https://doi.org/10.1101/2021.09.30.462573
Autor:
Durrant DE, Richards J, Tripathi A, Kellogg GE, Marchetti P, Eleopra M, Grisolia G, Simoni D, Lee RM
Publikováno v:
Investigational New Drugs; Feb2009, Vol. 27 Issue 1, p41-52, 12p
Autor:
Senadeera SPD; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States., Wang D; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States., Kim CK; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States., Smith EA; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.; Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory of Cancer Research, Frederick, Maryland 21702-1201, United States., Durrant DE; Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States., Alexander PA; National Cancer Institute RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland 21701, United States., Wendt KL; Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, and Natural Products Discovery Group and Institute for Natural Products Applications and Research Technologies, University of Oklahoma, Norman, Oklahoma 73019, United States., Stephen AG; National Cancer Institute RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland 21701, United States., Morrison DK; Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States., Cichewicz RH; Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, and Natural Products Discovery Group and Institute for Natural Products Applications and Research Technologies, University of Oklahoma, Norman, Oklahoma 73019, United States., Henrich CJ; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.; Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory of Cancer Research, Frederick, Maryland 21702-1201, United States., Beutler JA; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.
Publikováno v:
Journal of natural products [J Nat Prod] 2022 Jun 24; Vol. 85 (6), pp. 1603-1616. Date of Electronic Publication: 2022 Jun 13.
Autor:
Martinez Fiesco JA; Center for Structural Biology, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD, 21702, USA., Durrant DE; Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD, 21702, USA., Morrison DK; Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD, 21702, USA. morrisod@mail.nih.gov., Zhang P; Center for Structural Biology, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD, 21702, USA. ping.zhang@nih.gov.
Publikováno v:
Nature communications [Nat Commun] 2022 Jan 25; Vol. 13 (1), pp. 486. Date of Electronic Publication: 2022 Jan 25.
Autor:
Durrant DE; Laboratory of Cell and Developmental Signaling, NCI, Frederick, Maryland., Smith EA; Molecular Targets Program, Center of Cancer Research, NCI, Frederick, Maryland.; Basic Research Program, Leidos Biomedical Research, Inc., Frederick, Maryland., Goncharova EI; Molecular Targets Program, Center of Cancer Research, NCI, Frederick, Maryland.; Biomedical Informatics and Data Science Directorate, NCI, Frederick, Maryland., Sharma N; Molecular Targets Program, Center of Cancer Research, NCI, Frederick, Maryland., Alexander PA; NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland., Stephen AG; NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland., Henrich CJ; Molecular Targets Program, Center of Cancer Research, NCI, Frederick, Maryland. morrisod@mail.nih.gov curtis.henrich2@nih.gov.; Basic Research Program, Leidos Biomedical Research, Inc., Frederick, Maryland., Morrison DK; Laboratory of Cell and Developmental Signaling, NCI, Frederick, Maryland. morrisod@mail.nih.gov curtis.henrich2@nih.gov.
Publikováno v:
Molecular cancer therapeutics [Mol Cancer Ther] 2021 Sep; Vol. 20 (9), pp. 1743-1754. Date of Electronic Publication: 2021 Jun 22.
Autor:
Durrant DE; VCU Pauley Heart Center, Division of Cardiology, Virginia Commonwealth University, Richmond, VA 23298, United States., Das A; VCU Pauley Heart Center, Division of Cardiology, Virginia Commonwealth University, Richmond, VA 23298, United States., Dyer S; VCU Pauley Heart Center, Division of Cardiology, Virginia Commonwealth University, Richmond, VA 23298, United States., Kukreja RC; VCU Pauley Heart Center, Division of Cardiology, Virginia Commonwealth University, Richmond, VA 23298, United States. Electronic address: rakesh.kukreja@vcuhealth.org.
Publikováno v:
Biochimica et biophysica acta. General subjects [Biochim Biophys Acta Gen Subj] 2020 Jun; Vol. 1864 (6), pp. 129556. Date of Electronic Publication: 2020 Feb 14.
Autor:
Kim CK; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States., Wang D; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States., Bokesch HR; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.; Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702-1201, United States., Fuller RW; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States., Smith E; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.; Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702-1201, United States., Henrich CJ; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.; Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702-1201, United States., Durrant DE; Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States., Morrison DK; Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States., Bewley CA; Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20814, United States., Gustafson KR; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.
Publikováno v:
Journal of natural products [J Nat Prod] 2020 Apr 24; Vol. 83 (4), pp. 1288-1294. Date of Electronic Publication: 2020 Mar 19.
Autor:
Terrell EM; Laboratory of Cell and Developmental Signaling, NCI-Frederick, Frederick, MD 21702, USA., Durrant DE; Laboratory of Cell and Developmental Signaling, NCI-Frederick, Frederick, MD 21702, USA., Ritt DA; Laboratory of Cell and Developmental Signaling, NCI-Frederick, Frederick, MD 21702, USA., Sealover NE; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA., Sheffels E; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA., Spencer-Smith R; Laboratory of Cell and Developmental Signaling, NCI-Frederick, Frederick, MD 21702, USA., Esposito D; NCI-Ras Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Frederick, MD 21702, USA., Zhou Y; Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Hancock JF; Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Kortum RL; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA., Morrison DK; Laboratory of Cell and Developmental Signaling, NCI-Frederick, Frederick, MD 21702, USA. Electronic address: morrisod@mail.nih.gov.
Publikováno v:
Molecular cell [Mol Cell] 2019 Dec 19; Vol. 76 (6), pp. 872-884.e5. Date of Electronic Publication: 2019 Oct 09.
Autor:
Durrant DE; Laboratory of Cell and Developmental Signalling, National Cancer Institute - Frederick, 1050 Boyles Street, Frederick, MD 21702, USA., Morrison DK; Laboratory of Cell and Developmental Signalling, National Cancer Institute - Frederick, 1050 Boyles Street, Frederick, MD 21702, USA.
Publikováno v:
British journal of cancer [Br J Cancer] 2018 Jan; Vol. 118 (1), pp. 3-8. Date of Electronic Publication: 2017 Dec 14.
Autor:
Ritt DA; Laboratory of Cell and Developmental Signaling, NCI-Frederick, Frederick, MD 21702, USA., Abreu-Blanco MT; NCI-Ras Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Frederick, MD 21702, USA., Bindu L; NCI-Ras Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Frederick, MD 21702, USA., Durrant DE; Laboratory of Cell and Developmental Signaling, NCI-Frederick, Frederick, MD 21702, USA., Zhou M; NCI-Ras Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Frederick, MD 21702, USA., Specht SI; Laboratory of Cell and Developmental Signaling, NCI-Frederick, Frederick, MD 21702, USA., Stephen AG; NCI-Ras Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Frederick, MD 21702, USA., Holderfield M; NCI-Ras Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Frederick, MD 21702, USA., Morrison DK; Laboratory of Cell and Developmental Signaling, NCI-Frederick, Frederick, MD 21702, USA. Electronic address: morrisod@mail.nih.gov.
Publikováno v:
Molecular cell [Mol Cell] 2016 Dec 01; Vol. 64 (5), pp. 875-887. Date of Electronic Publication: 2016 Nov 23.