Synthesis and cytotoxicity of novel 6,8,9-trisubstituted purine analogs against liver cancer cells

Autor: Fatih Polat, M., Durmaz Şahin, Irem, Kul, Pınar, Cetin Atalay, Rengul, Tuncbilek, Meral

Publikováno v: In Bioorganic & Medicinal Chemistry Letters 1 July 2024 106

Exploration of novel 6,8,9-trisubstituted purine analogues: synthesis, in vitro biological evaluation, and their effect on human cancer cells.

Autor: Polat MF; Department of Pharmaceutical Basic Sciences, Faculty of Pharmacy, Erzincan Binali Yıldırım University, Erzincan, Turkiye., Durmaz Şahin İ; Research Center for Translational Medicine (KUTTAM), Koç University, İstanbul, Turkiye.; Department of Medical Biology, School of Medicine, Koç University, İstanbul, Turkiye.; Cancer Systems Biology Laboratory, Graduate School of Informatics, ODTU, Ankara, Turkiye., Atalay R; Cancer Systems Biology Laboratory, Graduate School of Informatics, ODTU, Ankara, Turkiye.; Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, USA., Tunçbilek M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Turkiye.

Publikováno v: Turkish journal of chemistry [Turk J Chem] 2023 Dec 04; Vol. 48 (1), pp. 108-115. Date of Electronic Publication: 2023 Dec 04 (Print Publication: 2024).