Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Durk, Dijkstra"'
Autor:
Meindert Danhof, Oscar Della Pasqua, Durk Dijkstra, Jeroen De Graan, Ben H.C. Westerink, Shanna Shi, Joke A. Bouwstra, Rob J. Vreeken, Oliver W. Ackaert
Publikováno v:
Journal of Pharmaceutical Sciences, 100(7), 2996-3009. ELSEVIER SCIENCE INC
The pharmacokinetic (PK) and pharmacodynamic (PD) properties of the active (S)-enantiomer of the potent dopamine (DA) agonist 5-hydroxy-2-(N,N,-di-n-propylamino)tetralin (5-OH-DPAT) were investigated in a novel anesthetized animal model. First, the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::419e8f23e7bc6916822fea1b9ab21da8
https://doi.org/10.1002/jps.22492
https://doi.org/10.1002/jps.22492
Autor:
Durk Dijkstra
Publikováno v:
Onderwijs en gezondheidszorg. 34:8-11
In gecompliceerde verpleegsituaties kan een procesmodel voor bewaking studenten en ervaren IC-verpleegkundigen helpen om het eigen handelen te organiseren en te evalueren.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3271d500e31d20ae4ebbab7b8da9c42a
https://doi.org/10.1007/bf03090018
https://doi.org/10.1007/bf03090018
Publikováno v:
Tetrahedron, 63(30), 7264-7270. PERGAMON-ELSEVIER SCIENCE LTD
We have previously demonstrated that the enone prodrug GMC-6650 acts as a highly efficient dopaminergic agonist. In vivo, this compound is bioactivated to its corresponding catecholamine, TL-334. The goal here was to investigate if this bioactivation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf93925c195906b2fc179acaf82db9d0
https://doi.org/10.1016/j.tet.2007.04.103
https://doi.org/10.1016/j.tet.2007.04.103
Publikováno v:
Journal of Medicinal Chemistry, 49(4), 1494-1498. AMER CHEMICAL SOC
Enone prodrugs of dopaminergic catecholamines represent a new type of prodrug in the research area of dopamine agonists. Here, we demonstrate the first benzo[g]quinoline-derived enone that induces potent dopamine agonist effects similar to arninotetr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c10080dca6bd542c4215a5388bffc1
https://doi.org/10.1021/jm051111h
https://doi.org/10.1021/jm051111h
Autor:
Li Li, Akhmad Kharis Nugroho, Meindert Danhof, Joke A. Bouwstra, Håkan Wikström, Durk Dijkstra
Publikováno v:
Journal of Controlled Release, 103(2), 393-403. Elsevier Bedrijfsinformatie b.v.
The feasibility of transdermal iontophoretic delivery of a potent dopamine agonist 5-OH-DPAT was studied in vitro in side by side diffusion cells across human stratum corneum (HSC) and dermatomed human skin (DHS) according to the following protocol:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e73abc37709dfb0eb0dfe34885f23e26
https://doi.org/10.1016/j.jconrel.2004.12.004
https://doi.org/10.1016/j.jconrel.2004.12.004
Publikováno v:
European Journal of Pharmacology, 394(2-3), 255-263. ELSEVIER SCIENCE BV
In the present study, a series of thiophene analogs of 2-aminotetralins and hexahydronaphthoxazines were studied in vivo for their ability to decrease striatal dopamine release, their effects on locomotor activity, and their behavioral characteristic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af01fd5a9197bb0b57c22e5ebc00a6d
https://doi.org/10.1016/s0014-2999(00)00145-x
https://doi.org/10.1016/s0014-2999(00)00145-x
Autor:
Jeffrey M. Witkin, Durk Dijkstra, M Beekman, Maciej Gasior, Jesse T. Ungard, Richard B. Carter
Publikováno v:
Psychopharmacology, 148(4), 336-343. SPRINGER
Rationale: Neuroactive steroids represent a novel class of potential therapeutic agents (epilepsy, anxiety, migraine, drug dependence) thought to act through positive allosteric modulation of the GABA(A) receptor A synthetically derived neuroactive s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b743d06a010c71f42b6cd6ba14605a
https://doi.org/10.1007/s002130050060
https://doi.org/10.1007/s002130050060
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 358:342-350
A 15-mer, all-phosphorothioate-modified antisense oligodeoxynucleotide (ASO) targeted against rat dopamine D3 receptor mRNA (4 microM, 5 days) significantly reduced (28%) the amount of binding sites labelled with [3H]spiperone in monolayer cultured C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6078e7d2d5b775f0fc464faf52ea657f
https://doi.org/10.1007/pl00005263
https://doi.org/10.1007/pl00005263
Autor:
Christer Halldin, Lars Farde, Håkan Wikström, Pierre Sokoloff, Håkan Hall, Thomas A. Pugsley, Lawrence D. Wise, Durk Dijkstra, Göran Sedvall, Stefan Pauli
Publikováno v:
Psychopharmacology, 128(3), 240-247. SPRINGER
The selective D-3-dopamine receptor agonist 4aR,10bR-(+)-trans-3,4,4a,10b-tetrahydro-4-[N-propyl-2,3- H-3]-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol ([H-3]PD 128907) was used to visualise D-3-dopamine receptors in whole hemisphere cryosections from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc832528fa9dbbe8de60afb880d1b76
https://research.rug.nl/en/publications/fdab8086-fe93-49e6-b5d3-e1db276c731d
https://research.rug.nl/en/publications/fdab8086-fe93-49e6-b5d3-e1db276c731d
Autor:
T. A. Barf, Durk Dijkstra, L. J. King, Kjell A. Svensson, I. J. Martin, M. W. Smith, J. N. Duncan, Jonas Nilsson, Håkan Wikström, Arvid Carlsson, Clas Sonesson
Publikováno v:
Journal of Medicinal Chemistry. 38:1319-1329
In order to explore further the structure-activity relationships of serotonergic and dopaminergic ligands, a series of enantiopure 5-, 7-, or 8-triflate (-OTf)-substituted 2-(monopropylamino)-tetralins have been synthesized and evaluated in in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f964c83141246da942b3aa9b6a195266
https://doi.org/10.1021/jm00008a010
https://doi.org/10.1021/jm00008a010