Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Durga Thakral"'
Autor:
Xinyi Zhang, Alexandra A. Halberstam, Wanling Zhu, Brooks P. Leitner, Durga Thakral, Marcus W. Bosenberg, Rachel J. Perry
Publikováno v:
Cancer & Metabolism, Vol 10, Iss 1, Pp 1-15 (2022)
Abstract Background Research about tumor “metabolic flexibility”—the ability of cells to toggle between preferred nutrients depending on the metabolic context—has largely focused on obesity-associated cancers. However, increasing evidence for
Externí odkaz:
https://doaj.org/article/734fa890ebb94da9bb588507745e7ac0
Autor:
Amit Mittal, Mike Wang, Aurobind Vidyarthi, Diana Yanez, Gabriela Pizzurro, Durga Thakral, Erin Tracy, Oscar R. Colegio
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Cutaneous squamous cell carcinomas (cSCC) are among the most commonly diagnosed malignancies, causing significant morbidity and mortality. Tumor-associated macrophage (TAM) expression of arginase is implicated in tumor progression, and thera
Externí odkaz:
https://doaj.org/article/96e8c37bc01d4a76b19b76c4448d098c
Autor:
Thomas M. Kuczmarski, Jacob Fox, Ethan Katznelson, Durga Thakral, Khin-Kyemon Aung, Emily Moore, Jonathan Eisen, Jonathan E Slutzman, Regina LaRocque, Caren G Solomon, Gregg L Furie, Paul F Dellaripa
Publikováno v:
The Journal of Climate Change and Health, Vol 4, Iss , Pp 100067- (2021)
The climate crisis is a threat to human health. Resident physicians in internal medicine need training that addresses the clinical implications of climate change and its effect on health. However, internal medicine residency curricula are already sat
Externí odkaz:
https://doaj.org/article/3bc85f343ccf4492a666291a2e04046c
Autor:
Shlomit Jessel, Wesley L. Cai, Xiaoni Liu, Kim Blenman, Carmen J. Booth, Marcus Bosenberg, Goran Micevic, Shang-Min Zhang, Yangyi Zhang, William Damsky, Harriet M. Kluger, Meaghan K. McGeary, Qin Yan, Jiesi Luo, Eric Song, Akiko Iwasaki, Durga Thakral, Mario Sznol, Mingzhu Yin, Lok Hei Chan, Lucia B. Jilaveanu
Publikováno v:
Nature. 598:682-687
Tumours use various strategies to evade immune surveillance1,2. Immunotherapies targeting tumour immune evasion such as immune checkpoint blockade have shown considerable efficacy on multiple cancers3,4 but are ineffective for most patients due to pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c935e3b9c47ac6de523df0827385669c
https://doi.org/10.1038/s41586-021-03994-2
https://doi.org/10.1038/s41586-021-03994-2
Autor:
Anjela Galan, William Damsky, Brett A. King, Meaghan K. McGeary, Jonathan S. Leventhal, Durga Thakral
Publikováno v:
Journal of the American Academy of Dermatology. 82:612-621
Background Sarcoidosis and granuloma annulare (GA) are cutaneous granulomatous disorders that can be difficult to treat. There is evidence of underlying Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway activation i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a984938f548294810475ccabc0e32c
https://doi.org/10.1016/j.jaad.2019.05.098
https://doi.org/10.1016/j.jaad.2019.05.098
Autor:
Ann T. Chen, Nur-Taz Rahman, Wesley L. Cai, Razib Obaid, Durga Thakral, Caitlin Meyer, Rolando Garcia-Milian
Publikováno v:
Medical reference services quarterly. 41(1)
As biomedical research becomes more data-intensive, bioinformatics is becoming essential to understanding biological processes, systems, and diseases. In this paper we describe the use of a series of peer teaching workshops as a strategy to respond t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d2df0e6fb95a9aef0967643c224f7e
https://pubmed.ncbi.nlm.nih.gov/35225737
https://pubmed.ncbi.nlm.nih.gov/35225737
Publikováno v:
New England Journal of Medicine. 379:2540-2546
There is evidence that Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling plays a role in the pathogenesis of sarcoidosis. We treated a patient with cutaneous sarcoidosis with the JAK inhibitor tofacitinib; the patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a11c2ad3e6050cd0c3aff38d6b0427bc
https://doi.org/10.1056/nejmoa1805958
https://doi.org/10.1056/nejmoa1805958
Autor:
Kim Blenman, Shang-Min Zhang, Marcus Bosenberg, Goran Micevic, Akiko Iwasaki, Durga Thakral, Mario Sznol, Qin Yan, Carmen J. Booth, William Damsky, Wesley L. Cai, Xiaoni Liu, Harriet M. Kluger, Meaghan K. McGeary, Lucia B. Jilaveanu
Epigenetic therapies are emerging strategies to prime host immune system to immunotherapies. Here we show that depletion of H3K4 demethylase KDM5B in melanoma cells induces anti-tumor T cell immunity through up-regulation of retroelements, which acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::533ba2de1e05a28ba70679d54b2d6ee7
https://doi.org/10.21203/rs.3.rs-87705/v1
https://doi.org/10.21203/rs.3.rs-87705/v1
Publikováno v:
Pigment Cell Melanoma Res
The aim of this study is to determine the significance of programmed death ligand 1 (PD-L1 or CD274) methylation in relation to PD-L1 expression and survival in melanoma. Despite the clinical importance of therapies targeting the PD-1/PD-L1 immune ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a642ae50bc94ac09ad57a95d81757e
https://doi.org/10.1111/pcmr.12745
https://doi.org/10.1111/pcmr.12745
Autor:
Kathryn Miller-Jensen, Marcus Bosenberg, Alexandra Kuhlmann, Durga Thakral, Curtis J. Perry, Joel W Sher, Andrés R. Muñoz-Rojas, Susan M. Kaech, Laura N Kellman, Victor Y. Du, William Damsky, Robert A. Amezquita, J. Wang, Katrina Meeth
Publikováno v:
The Journal of Experimental Medicine
Perry et al. show that myeloid-targeted immunotherapy with a combination of anti-CD40 and CSF-1R inhibition synergistically induces a proinflammatory microenvironment that suppresses CPI-resistant tumors in a TNF-α– and IFN-γ–dependent manner.<
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e82dbcdacb0511491dc13b80875f9696
https://doi.org/10.1084/jem.20171435
https://doi.org/10.1084/jem.20171435