Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium.

Autor: Milne RL; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Human Cancer Genetics Programme, roger.milne@cancervic.org.au., Burwinkel B; Department of Obstetrics and Gynecology, Molecular Epidemiology Group., Michailidou K; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care., Arias-Perez JI; Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain., Zamora MP; Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid, Spain., Menéndez-Rodríguez P; Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain., Hardisson D; Department of Pathology, Hospital Universitario La Paz, IdiPAZ (Hospital La Paz Institute for Health Research) Universidad Autonoma de Madrid, Madrid, Spain., Mendiola M; Laboratory of Pathology and Oncology, Research Unit, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain., González-Neira A; Human Genotyping-CEGEN Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Pita G; Human Genotyping-CEGEN Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Alonso MR; Human Genotyping-CEGEN Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Dennis J; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care., Wang Q; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care., Bolla MK; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care., Swerdlow A; Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, UK, Division of Breast Cancer Research., Ashworth A; Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research., Orr N; Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research., Schoemaker M; Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, UK., Ko YD; Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany., Brauch H; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany, University of Tübingen, Tübingen, Germany., Hamann U; Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany., Andrulis IL; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada, Department of Molecular Genetics., Knight JA; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada, Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada., Glendon G; Ontario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada., Tchatchou S; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Matsuo K; Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan., Ito H; Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan., Iwata H; Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan., Tajima K; Department of Public Health & Occupational Medicine, Mie University Graduate School of Medicine, Tsu, Japan., Li J; Human Genetics Division, Genome Institute of Singapore, Singapore., Brand JS; Department of Medical Epidemiology and Biostatistics., Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Consortium (DKTK), Heidelberg, Germany., Dieffenbach AK; Division of Clinical Epidemiology and Aging Research, German Cancer Consortium (DKTK), Heidelberg, Germany., Arndt V; Division of Clinical Epidemiology and Aging Research., Stegmaier C; Saarland Cancer Registry, Saarbrücken, Germany., Lambrechts D; Vesalius Research Center (VRC), VIB, Leuven, Belgium., Peuteman G; Vesalius Research Center (VRC), VIB, Leuven, Belgium., Christiaens MR; Multidisciplinary Breast Center, University Hospital Gasthuisberg, Leuven, Belgium., Smeets A; Multidisciplinary Breast Center, University Hospital Gasthuisberg, Leuven, Belgium., Jakubowska A; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Lubinski J; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Jaworska-Bieniek K; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Durda K; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Hartman M; Saw Swee Hock School of Public Health, Department of Surgery, Yong Loo Lin School of Medicine., Hui M; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Yen Lim W; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Wan Chan C; Department of Surgery, National University Health System, Singapore, Singapore., Marme F; Department of Obstetrics and Gynecology, National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany., Yang R; Department of Obstetrics and Gynecology, National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany., Bugert P; Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Lindblom A; Department of Molecular Medicine and Surgery., Margolin S; Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden., García-Closas M; Division of Breast Cancer Research, Breakthrough Breast Cancer Research Centre, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA, Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Lissowska J; Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology, Warsaw, Poland., Figueroa JD; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Bojesen SE; Copenhagen General Population Study, Herlev Hospital, Department of Clinical Biochemistry, Herlev Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Nordestgaard BG; Copenhagen General Population Study, Herlev Hospital, Department of Clinical Biochemistry, Herlev Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Flyger H; Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark., Hooning MJ; Department of Medical Oncology., Kriege M; Department of Medical Oncology., van den Ouweland AM; Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands., Koppert LB; Department of Surgical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands., Fletcher O; Breakthrough Breast Cancer Research Centre., Johnson N; Breakthrough Breast Cancer Research Centre., dos-Santos-Silva I; London School of Hygiene and Tropical Medicine, London, UK., Peto J; London School of Hygiene and Tropical Medicine, London, UK., Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Deming-Halverson S; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Shrubsole MJ; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Long J; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Chang-Claude J; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Rudolph A; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Seibold P; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Flesch-Janys D; Institute for Medical Biometrics and Epidemiology, Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Hamburg, Germany., Winqvist R; Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Northern Finland Laboratory Centre NordLab, Oulu, Finland., Pylkäs K; Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Northern Finland Laboratory Centre NordLab, Oulu, Finland., Jukkola-Vuorinen A; Department of Oncology., Grip M; Department of Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland., Cox A; CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology., Cross SS; Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, South Yorkshire, UK., Reed MW; CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology., Schmidt MK; Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands., Broeks A; Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands., Cornelissen S; Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands., Braaf L; Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands., Kang D; Department of Preventive Medicine, Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea, Cancer Research Institute, Seoul National University, Seoul, Korea., Choi JY; Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea, Cancer Research Institute, Seoul National University, Seoul, Korea., Park SK; Department of Preventive Medicine, Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea, Cancer Research Institute, Seoul National University, Seoul, Korea., Noh DY; Department of Surgery, Seoul National University College of Medicine, Seoul, Korea., Simard J; Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, QC, Canada., Dumont M; Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, QC, Canada., Goldberg MS; Department of Medicine, McGill University, Montreal, QC, Canada, Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, Montreal, QC, Canada., Labrèche F; Département de médecine sociale et préventive, Département de santé environnementale et santé au travail, Université de Montréal, Montreal, QC, Canada., Fasching PA; University Breast Center Franconia, Department of Gynecology and Obstetrics, David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, CA, USA., Hein A; University Breast Center Franconia, Department of Gynecology and Obstetrics., Ekici AB; Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany., Beckmann MW; University Breast Center Franconia, Department of Gynecology and Obstetrics., Radice P; Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine., Peterlongo P; IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy., Azzollini J; Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy., Barile M; Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy., Sawyer E; Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy's & St. Thomas' NHS Foundation Trust in partnership with King's College London, London, UK., Tomlinson I; Wellcome Trust Centre for Human Genetics, Oxford Biomedical Research Centre, University of Oxford, Oxford, UK., Kerin M; School of Medicine, Clinical Science Institute, National University of Ireland, Galway, Ireland., Miller N; School of Medicine, Clinical Science Institute, National University of Ireland, Galway, Ireland., Hopper JL; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health., Schmidt DF; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health., Makalic E; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health., Southey MC; Department of Pathology, The University of Melbourne, Melbourne, Australia., Hwang Teo S; Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia, Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia., Har Yip C; Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia., Sivanandan K; Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia., Tay WT; Singapore Eye Research Institute, National University of Singapore, Singapore, Singapore., Shen CY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, College of Public Health, China Medical University, Taichong, Taiwan., Hsiung CN; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Yu JC; Tri-Service General Hospital, Taipei, Taiwan., Hou MF; Cancer Center, Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan., Guénel P; Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France, University Paris-Sud, UMRS 1018, Villejuif, France., Truong T; Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France, University Paris-Sud, UMRS 1018, Villejuif, France., Sanchez M; Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France, University Paris-Sud, UMRS 1018, Villejuif, France., Mulot C; Inserm (National Institute of Health and Medical Research), U775, Paris, France, Centre de Ressources Biologiques EPIGENETEC, Paris, France., Blot W; Department of Medicine, Vanderbilt University, Nashville, TN, USA., Cai Q; Department of Medicine, Vanderbilt University, Nashville, TN, USA., Nevanlinna H; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland., Muranen TA; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland., Aittomäki K; Department of Clinical Genetics., Blomqvist C; Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland., Wu AH; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Tseng CC; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Van Den Berg D; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Stram DO; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Bogdanova N; Department of Obstetrics and Gynaecology, Department of Radiation Oncology, Hannover Medical School, Hannover, Germany., Dörk T; Department of Obstetrics and Gynaecology., Muir K; Institute of Population Health, University of Manchester, Manchester, UK, Division of Health Sciences, Warwick Medical School, Coventry, UK., Lophatananon A; Division of Health Sciences, Warwick Medical School, Coventry, UK., Stewart-Brown S; Division of Health Sciences, Warwick Medical School, Coventry, UK., Siriwanarangsan P; Ministry of Public Health, Thailand., Mannermaa A; School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, Department of Clinical Pathology., Kataja V; Biocenter Kuopio, School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland, Kuopio, Finland, Cancer Center, Kuopio University Hospital, Kuopio, Finland., Kosma VM; School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, Department of Clinical Pathology., Hartikainen JM; School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, Department of Clinical Pathology., Shu XO; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Lu W; Shanghai Center for Disease Control and Prevention, Shanghai, China., Gao YT; Shanghai Cancer Institute, Shanghai, China., Zhang B; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Couch FJ; Department of Laboratory Medicine and Pathology, Department of Health Sciences Research., Toland AE; Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA., Yannoukakos D; Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece., Sangrajrang S; National Cancer Institute, Bangkok, Thailand., McKay J; Genetic Susceptibility Group, International Agency for Research on Cancer, Lyon, France., Wang X; Department of Laboratory Medicine and Pathology., Olson JE; Department of Health Sciences Research., Vachon C; Department of Health Sciences Research., Purrington K; Department of Health Sciences Research., Severi G; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health., Baglietto L; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health., Haiman CA; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Henderson BE; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Schumacher F; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Le Marchand L; University of Hawaii Cancer Center, Honolulu, HI, USA., Devilee P; Department of Human Genetics and., Tollenaar RA; Department of Surgical Oncology, Leiden University Medical Center, Leiden, The Netherlands., Seynaeve C; Department of Medical Oncology., Czene K; Department of Medical Epidemiology and Biostatistics., Eriksson M; Department of Medical Epidemiology and Biostatistics., Humphreys K; Department of Medical Epidemiology and Biostatistics., Darabi H; Department of Medical Epidemiology and Biostatistics., Ahmed S; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Shah M; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Pharoah PD; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Hall P; Department of Medical Epidemiology and Biostatistics., Giles GG; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health., Benítez J; Human Cancer Genetics Programme, Human Genotyping-CEGEN Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Dunning AM; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Chenevix-Trench G; QIMR Berghofer Institute of Medical Research, Brisbane, Australia., Easton DF; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.

Publikováno v: Human molecular genetics [Hum Mol Genet] 2014 Nov 15; Vol. 23 (22), pp. 6096-111. Date of Electronic Publication: 2014 Jun 18.