Towards a universal method for middle-down analysis of antibodies via proton transfer charge reduction-Orbitrap mass spectrometry.

Autor: Oates RN; Department Chemistry and Biochemistry, University of Oklahoma, Norman, OK, 73109, USA., Lieu LB; Department Chemistry and Biochemistry, University of Oklahoma, Norman, OK, 73109, USA., Kline JT; School of Biological Sciences, University of Oklahoma, Richards Hall 411B, 730 Van Vleet Oval, Norman, OK, 73109, USA., Mullen C; Thermo Fisher Scientific, San Jose, CA, 35134, USA., Srzentić K; Thermo Fisher Scientific, CH-4153, Reinach, Switzerland., Huguet R; Thermo Fisher Scientific, San Jose, CA, 35134, USA., McAlister GC; Thermo Fisher Scientific, San Jose, CA, 35134, USA., Huang J; Thermo Fisher Scientific, San Jose, CA, 35134, USA., Bergen D; Thermo Fisher Scientific, San Jose, CA, 35134, USA., Melani RD; Thermo Fisher Scientific, San Jose, CA, 35134, USA., Zabrouskov V; Thermo Fisher Scientific, San Jose, CA, 35134, USA., Durbin KR; Proteinaceous, Inc, Evanston, IL, 60626, USA., Syka JEP; Thermo Fisher Scientific, San Jose, CA, 35134, USA., Fornelli L; Department Chemistry and Biochemistry, University of Oklahoma, Norman, OK, 73109, USA. luca.fornelli@ou.edu.; School of Biological Sciences, University of Oklahoma, Richards Hall 411B, 730 Van Vleet Oval, Norman, OK, 73109, USA. luca.fornelli@ou.edu.

Publikováno v: Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2024 Nov; Vol. 416 (28), pp. 6463-6472. Date of Electronic Publication: 2024 Sep 16.

BCL-X L -targeting antibody-drug conjugates are active in preclinical models and mitigate on-mechanism toxicity of small-molecule inhibitors.

Autor: Judd AS; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Bawa B; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Buck WR; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Tao ZF; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Li Y; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Mitten MJ; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Bruncko M; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Catron N; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Doherty G; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Durbin KR; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Enright B; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Frey R; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Haasch D; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Haman S; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Haight AR; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Henriques TA; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Holms J; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Izeradjene K; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Judge RA; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Jenkins GJ; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Kunzer A; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Leverson JD; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Martin RL; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Mitra D; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Mittelstadt S; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Nelson L; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Nimmer P; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Palma J; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Peterson R; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Phillips DC; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Ralston SL; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Rosenberg SH; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Shen X; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Song X; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Vaidya KR; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Wang X; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Wang J; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Xiao Y; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Zhang H; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Zhang X; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Blomme EA; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Boghaert ER; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Kalvass JC; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Phillips A; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA., Souers AJ; AbbVie Inc., 1 N. Waukegan Road, North Chicago, IL 60064, USA.

Publikováno v: Science advances [Sci Adv] 2024 Oct 04; Vol. 10 (40), pp. eado7120. Date of Electronic Publication: 2024 Oct 04.

Filling the gaps in peptide maps with a platform assay for top-down characterization of purified protein samples.

Autor: Bailey AO; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA., Durbin KR; Proteinaceous Inc., Evanston, Illinois, USA., Robey MT; Proteinaceous Inc., Evanston, Illinois, USA., Palmer LK; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA., Russell WK; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA.

Publikováno v: Proteomics [Proteomics] 2024 Jul 14, pp. e2400036. Date of Electronic Publication: 2024 Jul 14.

Author Correction: Automated imaging and identification of proteoforms directly from ovarian cancer tissue.

Autor: McGee JP; Departments of Molecular Biosciences, Chemistry, and the Feinberg School of Medicine, Northwestern University, Evanston, IL, USA., Su P; Departments of Molecular Biosciences, Chemistry, and the Feinberg School of Medicine, Northwestern University, Evanston, IL, USA., Durbin KR; Proteomics Center of Excellence, Evanston, IL, USA., Hollas MAR; Proteomics Center of Excellence, Evanston, IL, USA., Bateman NW; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, Bethesda, MD, USA.; Department of Gynecologic Surgery and Obstetrics and the Gynecologic Cancer Center of Excellence, John P. Murtha Cancer Center, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Maxwell GL; Department of Gynecologic Surgery and Obstetrics and the Gynecologic Cancer Center of Excellence, John P. Murtha Cancer Center, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; Women's Health Integrated Research Center, Inova Women's Service Line, Inova Health System, Falls Church, VA, USA., Conrads TP; Department of Gynecologic Surgery and Obstetrics and the Gynecologic Cancer Center of Excellence, John P. Murtha Cancer Center, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; Women's Health Integrated Research Center, Inova Women's Service Line, Inova Health System, Falls Church, VA, USA., Fellers RT; Proteomics Center of Excellence, Evanston, IL, USA., Melani RD; Departments of Molecular Biosciences, Chemistry, and the Feinberg School of Medicine, Northwestern University, Evanston, IL, USA., Camarillo JM; Departments of Molecular Biosciences, Chemistry, and the Feinberg School of Medicine, Northwestern University, Evanston, IL, USA.; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Kafader JO; Departments of Molecular Biosciences, Chemistry, and the Feinberg School of Medicine, Northwestern University, Evanston, IL, USA.; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Kelleher NL; Departments of Molecular Biosciences, Chemistry, and the Feinberg School of Medicine, Northwestern University, Evanston, IL, USA. n-kelleher@northwestern.edu.; Proteomics Center of Excellence, Evanston, IL, USA. n-kelleher@northwestern.edu.; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. n-kelleher@northwestern.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Dec 01; Vol. 14 (1), pp. 7946. Date of Electronic Publication: 2023 Dec 01.

Automated imaging and identification of proteoforms directly from ovarian cancer tissue.

Autor: McGee JP; Departments of Molecular Biosciences, Chemistry, and the Feinberg School of Medicine, Northwestern University, Evanston, IL, USA., Su P; Departments of Molecular Biosciences, Chemistry, and the Feinberg School of Medicine, Northwestern University, Evanston, IL, USA., Durbin KR; Proteomics Center of Excellence, Evanston, IL, USA., Hollas MAR; Proteomics Center of Excellence, Evanston, IL, USA., Bateman NW; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, Bethesda, MD, USA.; Department of Gynecologic Surgery and Obstetrics and the Gynecologic Cancer Center of Excellence, John P. Murtha Cancer Center, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Maxwell GL; Department of Gynecologic Surgery and Obstetrics and the Gynecologic Cancer Center of Excellence, John P. Murtha Cancer Center, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; Women's Health Integrated Research Center, Inova Women's Service Line, Inova Health System, Falls Church, VA, USA., Conrads TP; Department of Gynecologic Surgery and Obstetrics and the Gynecologic Cancer Center of Excellence, John P. Murtha Cancer Center, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; Women's Health Integrated Research Center, Inova Women's Service Line, Inova Health System, Falls Church, VA, USA., Fellers RT; Proteomics Center of Excellence, Evanston, IL, USA., Melani RD; Departments of Molecular Biosciences, Chemistry, and the Feinberg School of Medicine, Northwestern University, Evanston, IL, USA., Camarillo JM; Departments of Molecular Biosciences, Chemistry, and the Feinberg School of Medicine, Northwestern University, Evanston, IL, USA.; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Kafader JO; Departments of Molecular Biosciences, Chemistry, and the Feinberg School of Medicine, Northwestern University, Evanston, IL, USA.; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Kelleher NL; Departments of Molecular Biosciences, Chemistry, and the Feinberg School of Medicine, Northwestern University, Evanston, IL, USA. n-kelleher@northwestern.edu.; Proteomics Center of Excellence, Evanston, IL, USA. n-kelleher@northwestern.edu.; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. n-kelleher@northwestern.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Oct 14; Vol. 14 (1), pp. 6478. Date of Electronic Publication: 2023 Oct 14.