Identification and Characterization of Approved Drugs and Drug-Like Compounds as Covalent Escherichia coli ClpP Inhibitors

Autor: Sassetti, E., Durante Cruz, C., Tammela, P., Winterhalter, M., Augustyns, K., Gribbon, P., Windshügel, B.

Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 11, p 2686 (2019)
International journal of molecular sciences
International Journal of Molecular Sciences
Volume 20
Issue 11

The serine protease Caseinolytic protease subunit P (ClpP) plays an important role for protein homeostasis in bacteria and contributes to various developmental processes, as well as virulence. Therefore, ClpP is considered as a potential drug target

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::45361aa4f1773b55cc089706990b0a04
https://www.mdpi.com/1422-0067/20/11/2686

New N-phenylpyrrolamide DNA gyrase B inhibitors: Optimization of efficacy and antibacterial activity.

Autor: Durcik M; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000, Ljubljana, Slovenia., Lovison D; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000, Ljubljana, Slovenia., Skok Ž; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000, Ljubljana, Slovenia., Durante Cruz C; Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), 00014, Helsinki, Finland., Tammela P; Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), 00014, Helsinki, Finland., Tomašič T; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000, Ljubljana, Slovenia., Benedetto Tiz D; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000, Ljubljana, Slovenia., Draskovits G; Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, H-6726, Hungary., Nyerges Á; Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, H-6726, Hungary., Pál C; Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, H-6726, Hungary., Ilaš J; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000, Ljubljana, Slovenia., Peterlin Mašič L; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000, Ljubljana, Slovenia., Kikelj D; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000, Ljubljana, Slovenia., Zidar N; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000, Ljubljana, Slovenia. Electronic address: nace.zidar@ffa.uni-lj.si.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2018 Jun 25; Vol. 154, pp. 117-132. Date of Electronic Publication: 2018 May 10.

High yield synthesis of trans-azoxybenzene versus 2-isopropoxy-4-nitrobenzoic acid: influence of temperature and base concentration.

Autor: Nué-Martínez, J. Jonathan¹, Alkorta, Ibon¹, Dardonville, Christophe¹ dardonville@iqm.csic.es

Publikováno v: ARKIVOC: Online Journal of Organic Chemistry. 2021, Vol. 2021, p265-276. 12p.

Identification of promising anti-DNA gyrase antibacterial compounds using de novo design, molecular docking and molecular dynamics studies.

Autor: Islam, Md Ataul, Pillay, Tahir S.

Publikováno v: Journal of Biomolecular Structure & Dynamics; Apr2020, Vol. 38 Issue 6, p1798-1809, 12p

Hybrid Inhibitors of DNA Gyrase A and B: Design, Synthesis and Evaluation.

Autor: Durcik, Martina¹ (AUTHOR) martina.durcik@ffa.uni-lj.si, Skok, Žiga¹ (AUTHOR) ziga.skok@ffa.uni-lj.si, Ilaš, Janez¹ (AUTHOR) janez.ilas@ffa.uni-lj.si, Zidar, Nace¹ (AUTHOR) nace.zidar@ffa.uni-lj.si, Zega, Anamarija¹ (AUTHOR) anamarija.zega@ffa.uni-lj.si, Szili, Petra Éva² (AUTHOR) szilipetraeva@gmail.com, Draskovits, Gábor² (AUTHOR) dras.gabor@gmail.com, Révész, Tamás² (AUTHOR) tamas.revesz.1@gmail.com, Kikelj, Danijel¹ (AUTHOR) danijel.kikelj@ffa.uni-lj.si, Nyerges, Akos^2,3 (AUTHOR) nyerges.akos@brc.hu, Pál, Csaba² (AUTHOR) cpal@brc.hu, Mašič, Lucija Peterlin¹ (AUTHOR) lucija.peterlinmasic@ffa.uni-lj.si, Tomašič, Tihomir¹ (AUTHOR) lucija.peterlinmasic@ffa.uni-lj.si

Publikováno v: Pharmaceutics. Jan2021, Vol. 13 Issue 1, p6. 1p.