Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Duran Ramsuran"'
Autor:
Thabo Mpotje, Kerishka Rajkumar-Bhugeloo, Thumbi Ndung'u, Duran Ramsuran, Mohlopheni J Marakalala, Denelle Moodley, Kimone L Fisher
Publikováno v:
Gates Open Research, Vol 5 (2022)
Background: Neutrophils are one of the major early role players in antimycobacterial immunity. Upon infection, neutrophils can undergo NETosis, a cell death characterized by release of neutrophil extracellular traps (NETs). The role of NETosis in TB
Externí odkaz:
https://doaj.org/article/cea9149a8d4a442ba46d117a4215f2ee
Autor:
Thabo Mpotje, Kerishka Rajkumar-Bhugeloo, Thumbi Ndung'u, Duran Ramsuran, Mohlopheni J Marakalala, Denelle Moodley, Kimone L Fisher
Publikováno v:
Gates Open Research, Vol 5 (2021)
Background: Neutrophils are one of the major early role players in antimycobacterial immunity. Upon infection, neutrophils can undergo NETosis, a cell death characterized by release of neutrophil extracellular traps (NETs). The role of NETosis in TB
Externí odkaz:
https://doaj.org/article/77b5e7ace882438982ff59181b049455
Autor:
Julia Roider, Takashi Maehara, Abigail Ngoepe, Duran Ramsuran, Maximilian Muenchhoff, Emily Adland, Toby Aicher, Samuel W. Kazer, Pieter Jooste, Farina Karim, Warren Kuhn, Alex K. Shalek, Thumbi Ndung'u, Lynn Morris, Penny L. Moore, Shiv Pillai, Henrik Kløverpris, Philip Goulder, Alasdair Leslie
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Broadly neutralizing antibodies (bnAbs) against HIV-1 are an effective means of preventing transmission. To better understand the mechanisms by which HIV-specific bnAbs naturally develop, we investigated blood and lymphoid tissue in pediatric infecti
Externí odkaz:
https://doaj.org/article/c66447ad8ffe40e48105ac1cf348eb35
Autor:
Cláudio Nunes-Alves, Matthew G Booty, Stephen M Carpenter, Alissa C Rothchild, Constance J Martin, Danielle Desjardins, Katherine Steblenko, Henrik N Kløverpris, Rajhmun Madansein, Duran Ramsuran, Alasdair Leslie, Margarida Correia-Neves, Samuel M Behar
Publikováno v:
PLoS Pathogens, Vol 11, Iss 5, p e1004849 (2015)
The immune system can recognize virtually any antigen, yet T cell responses against several pathogens, including Mycobacterium tuberculosis, are restricted to a limited number of immunodominant epitopes. The host factors that affect immunodominance a
Externí odkaz:
https://doaj.org/article/b649e79c83074039910e479c4c31f14b
Autor:
Alessandra Nardin, Rajhmun Madansein, Amanda Ardain, Khadija Khan, Kaylesh J. Dullabh, Alveera Singh, Taryn Naidoo, Alessandro Sette, Farina Karim, Samuel M. Behar, Alasdair Leslie, Paul T. Elkington, Liku B. Tezera, Duran Ramsuran, Michael G. Fehlings, Abigail Ngoepe, Paul Ogongo, Cecilia S. Lindestam Arlehamn, Henrik N. Kløverpris, Shepherd Nhamoyebonde, Adrie J. C. Steyn, Boon Heng Lee
Publikováno v:
The Journal of Clinical Investigation
Ogongo, P, Tezera, L B, Ardain, A, Nhamoyebonde, S, Ramsuran, D, Singh, A, Ng’oepe, A, Karim, F, Naidoo, T, Khan, K, Dullabh, K J, Fehlings, M, Lee, B H, Nardin, A, Lindestam Arlehamn, C S, Sette, A, Behar, S M, Steyn, A J C, Madansein, R, Kløverpris, H N, Elkington, P T & Leslie, A 2021, ' Tissue-resident-like CD4 + T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung ', Journal of Clinical Investigation, vol. 131, no. 10, e142014 . https://doi.org/10.1172/JCI142014
Ogongo, P, Tezera, L B, Ardain, A, Nhamoyebonde, S, Ramsuran, D, Singh, A, Ng’oepe, A, Karim, F, Naidoo, T, Khan, K, Dullabh, K J, Fehlings, M, Lee, B H, Nardin, A, Lindestam Arlehamn, C S, Sette, A, Behar, S M, Steyn, A J C, Madansein, R, Kløverpris, H N, Elkington, P T & Leslie, A 2021, ' Tissue-resident-like CD4 + T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung ', Journal of Clinical Investigation, vol. 131, no. 10, e142014 . https://doi.org/10.1172/JCI142014
T cell immunity is essential for the control of tuberculosis (TB), an important disease of the lung, and is generally studied in humans using peripheral blood cells. Mounting evidence, however, indicates that tissue-resident memory T cells (Trms) are
Autor:
Kimone L Fisher, Kerishka Rajkumar-Bhugeloo, Denelle Moodley, Thabo Mpotje, Duran Ramsuran, Thumbi Ndung'u, Mohlopheni J Marakalala
Publikováno v:
Gates Open Research. 5:175
Background: Neutrophils are one of the major early role players in antimycobacterial immunity. Upon infection, neutrophils can undergo NETosis, a cell death characterized by release of neutrophil extracellular traps (NETs). The role of NETosis in TB
Autor:
Warren Kuhn, Duran Ramsuran, Maximilian Muenchhoff, Philip J. R. Goulder, Jane Millar, Alasdair Leslie, J Roider, Alex K. Shalek, Thumbi Ndung'u, Henrik N. Kløverpris, Osaretin E. Asowata, Kami C. Krista, Samuel W. Kazer, Amanda Ardain, Farina Karim, Abigail Ngoepe, Rabiah Fardoos, Alveera Singh
Publikováno v:
Cell Reports
Singh, A, Kazer, S W, Roider, J, Krista, K C, Millar, J, Asowata, O E, Ngoepe, A, Ramsuran, D, Fardoos, R, Ardain, A, Muenchhoff, M, Kuhn, W, Karim, F, Ndung'u, T, Shalek, A K, Goulder, P, Leslie, A & Kløverpris, H N 2020, ' Innate Lymphoid Cell Activation and Sustained Depletion in Blood and Tissue of Children Infected with HIV from Birth Despite Antiretroviral Therapy ', Cell Reports, vol. 32, no. 11, 108153 . https://doi.org/10.1016/j.celrep.2020.108153
Singh, A, Kazer, S W, Roider, J, Krista, K C, Millar, J, Asowata, O E, Ngoepe, A, Ramsuran, D, Fardoos, R, Ardain, A, Muenchhoff, M, Kuhn, W, Karim, F, Ndung'u, T, Shalek, A K, Goulder, P, Leslie, A & Kløverpris, H N 2020, ' Innate Lymphoid Cell Activation and Sustained Depletion in Blood and Tissue of Children Infected with HIV from Birth Despite Antiretroviral Therapy ', Cell Reports, vol. 32, no. 11, 108153 . https://doi.org/10.1016/j.celrep.2020.108153
Summary Innate lymphoid cells (ILCs) are important for response to infection and for immune development in early life. HIV infection in adults depletes circulating ILCs, but the impact on children infected from birth remains unknown. We study vertica
Autor:
Rabiah Fardoos, Alasdair Leslie, Amanda Ardain, Alex K. Shalek, Duran Ramsuran, Alveera Singh, Jane Millar, Warren Kuhn, Thumbi Ndung'u, Henrik N. Kløverpris, Farina Karim, Osaretin E. Asowata, Philip J. R. Goulder, Julia Roider, Abigail Ngoepe, Kami C. Krista, Samuel W. Kazer, Maximilian Muenchhoff
Publikováno v:
SSRN Electronic Journal.
Innate lymphoid cells (ILCs) are important for response to infection and immune development in early life. HIV infection in adults has a profound effect on ILCs, but the impact from birth is unknown. Here we studied vertically HIV infected children f
Autor:
Nicole C Howard, William G. C. Horsnell, Amanda Ardain, Shabaana A. Khader, Javier Rangel-Moreno, Alveera Singh, Shibali Das, Tyler K. Ulland, Alex K. Shalek, Takashi Ebihara, Jay K. Kolls, Wayne M. Yokoyama, Mushtaq Ahmed, Rajhmun Madansein, Samuel W. Kazer, Nancy Marin-Agudelo, Maria de la Luz Garcia-Hernandez, Kaylesh J. Dullabh, Thumbi Ndung'u, Lan Lu, Micah D. Dunlap, Matthew Darby, Paul Ogongo, Duran Ramsuran, Alexander Pym, Joaquín Zúñiga, Deepak Kaushal, Marco Colonna, Alasdair Leslie, Racquel Domingo-Gonzalez, Eugene Park, Farina Karim, Henrik N. Kløverpris, Shepherd Nhamoyebonde, Adrie J. C. Steyn, Laura Melocchi
Publikováno v:
Nature. 572:E10-E10
Publikováno v:
Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health. 2:43-47
Introduction Pre-eclampsia is a significant cause of maternal and neonatal mortality and morbidity in resource constrained countries. Because the exact aetiology is unknown, treatment of preeclampsia is empiric. Therefore, researchers have been inves