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Synthesis and Stereochemical Assignment of Conioidine A: DNA- and HSA-Binding Studies of the Four Diastereomers

Autor: Ryan Shaktah, Lawrence A. Shaktah, Dupre Orr, Laura Vardanyan, Alexis Aleman, Thomas G. Minehan, Elroma David, Daniel Tamae

Publikováno v: Journal of Natural Products. 83:3191-3198

Conioidine A (1), isolated in 1993 with unknown relative and absolute configuration, was suggested to be a DNA-binding compound by an indirect technique. Four stereoisomers of conioidine A have been synthesized from d- and l-proline, and the natural

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b23e7331f3a60133d2099846955f036a
https://doi.org/10.1021/acs.jnatprod.0c00871

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Ring Expansion, Ring Contraction, and Annulation Reactions of Allylic Phosphonates under Oxidative Cleavage Conditions

Autor: Thomas G. Minehan, Dupre Orr, Nikolas Yousefi

Publikováno v: Organic Letters. 20:2839-2843

Oxidative cleavage of cycloalkenylalkylphosphonates 1 followed by treatment with base gives rise to homologated cycloalkenones 2 in good to excellent yields. Subjecting cycloalk-2-enylphosphonates 3 to identical conditions provides the one-carbon rin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74dbf53d0d82ac3e59f41fd3d0b7d9d4
https://doi.org/10.1021/acs.orglett.8b00791

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