Population genomics and transcriptomics of Plasmodium falciparum in Cambodia and Vietnam uncover key components of the artemisinin resistance genetic background

Autor: Sourav Nayak, Thomas J. Peto, Michal Kucharski, Rupam Tripura, James J. Callery, Duong Tien Quang Huy, Mathieu Gendrot, Dysoley Lek, Ho Dang Trung Nghia, Rob W. van der Pluijm, Nguyen Dong, Le Thanh Long, Ranitha Vongpromek, Huy Rekol, Nguyen Hoang Chau, Olivo Miotto, Mavuto Mukaka, Mehul Dhorda, Lorenz von Seidlein, Mallika Imwong, Xavier Roca, Nicholas P. J. Day, Nicholas J. White, Arjen M. Dondorp, Zbynek Bozdech

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract The emergence of Plasmodium falciparum parasites resistant to artemisinins compromises the efficacy of Artemisinin Combination Therapies (ACTs), the global first-line malaria treatment. Artemisinin resistance is a complex genetic trait in wh

Externí odkaz: https://doaj.org/article/29b3bb4812894fb0b0a2f1767eeb054b

The artemisinin-induced dormant stages of Plasmodium falciparum exhibit hallmarks of cellular quiescence/senescence and drug resilience.

Autor: Tripathi J; School of Biological Sciences, Nanyang Technological University (NTU), Singapore, 637551, Singapore. jtmic@nus.edu.sg.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117597, Singapore. jtmic@nus.edu.sg., Stoklasa M; School of Biological Sciences, Nanyang Technological University (NTU), Singapore, 637551, Singapore., Nayak S; School of Biological Sciences, Nanyang Technological University (NTU), Singapore, 637551, Singapore., En Low K; Electron Microscopy Unit, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117597, Singapore., Qian Hui Lee E; Department of Microbiology and Immunology, Immunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117597, Singapore., Duong Tien QH; School of Biological Sciences, Nanyang Technological University (NTU), Singapore, 637551, Singapore., Rénia L; School of Biological Sciences, Nanyang Technological University (NTU), Singapore, 637551, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University (NTU), Singapore, 636921, Singapore.; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore., Malleret B; Electron Microscopy Unit, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117597, Singapore.; Department of Microbiology and Immunology, Immunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117597, Singapore., Bozdech Z; School of Biological Sciences, Nanyang Technological University (NTU), Singapore, 637551, Singapore. zbozdech@ntu.edu.sg.

Publikováno v: Nature communications [Nat Commun] 2024 Aug 29; Vol. 15 (1), pp. 7485. Date of Electronic Publication: 2024 Aug 29.