Human versus equine intramuscular antitoxin, with or without human intrathecal antitoxin, for the treatment of adults with tetanus: a 2x2 factorial randomized control trial

Autor: Van Hao, N, Loan, HT, Yen, LM, Kestelyn, E, Hong, DD, Thuy, DB, Nguyen, NT, Duong, HTH, Diem Thuy, TT, Huy Nhat, PT, Quoc Khanh, PN, Phuong Dung, NT, Hoan Phu, N, Thanh Phong, N, Thi Lieu, P, Thi Tuyen, P, Bich Hanh, BT, Trung Nghia, HD, Nguyet Oanh, PK, Vinh Tho, P, Tan Thanh, T, Turner, H, Van Doorn, HR, Van Tan, L, Wyncoll, D, Day, NPJ, Geskus, RB, Thwaites, GE, Vinh Chau, NV, Thwaites, CL

Background: Intramuscular antitoxin is recommended in tetanus treatment, but there are few data comparing human and equine preparations. As tetanus toxin acts within the central nervous system, where there is limited penetration of peripherally-admin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::4fca9efef316e969600cb62c6e270cc4
http://hdl.handle.net/10044/1/95851

Heart Rate Variability Measured from Wearable Devices as a Marker of Disease Severity in Tetanus.

Autor: Hai HB; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Cattrall JWS; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Department of Psychiatry, University of Oxford, United Kingdom., Hao NV; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.; University Medicine and Pharmacy, Ho Chi Minh City, Vietnam., Van HMT; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Thuy DB; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Nhat PTH; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Khanh PNQ; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Duong HTH; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine and Global Health, University of Oxford, United Kingdom., Duong TD; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Lu P; Institute of Biomedical Engineering, University of Oxford, United Kingdom., Phuong LT; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Greeff H; Institute of Biomedical Engineering, University of Oxford, United Kingdom., Zhu T; Institute of Biomedical Engineering, University of Oxford, United Kingdom., Yen LM; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Clifton D; Institute of Biomedical Engineering, University of Oxford, United Kingdom., Thwaites CL; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine and Global Health, University of Oxford, United Kingdom.

Publikováno v: The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2023 Nov 20; Vol. 110 (1), pp. 165-169. Date of Electronic Publication: 2023 Nov 20 (Print Publication: 2024).

Urinary catecholamine excretion, cardiovascular variability, and outcomes in tetanus.

Autor: Du DH; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam. ducdh@oucru.org., Hao NQN; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; University Medical Center, Ho Chi Minh City, Vietnam., Van Hao N; University Medical Center, Ho Chi Minh City, Vietnam.; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Thanh TT; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Loan HT; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Yen LM; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Thuy TTD; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Thuy DB; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Nguyen NT; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Dung NTP; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Kestelyn E; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK., Duong HTH; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Phong NT; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Tuyen PT; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Phu NH; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Nghia HDT; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.; Pham Ngoc, Thach Medicine University, Ho Chi Minh City, Vietnam., Hanh BTB; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.; Pham Ngoc, Thach Medicine University, Ho Chi Minh City, Vietnam., Oanh PKN; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Tho PV; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Nhat PTH; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Khanh PNQ; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Wyncoll D; Guys and St, Thomas' Hospitals, London, UK., Day NPJ; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.; Mahidol Oxford Research Unit, Bangkok, Thailand., Van Vinh Chau N; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., van Doorn HR; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK., Van Tan L; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Geskus RB; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK., Thwaites CL; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.

Publikováno v: Tropical medicine and health [Trop Med Health] 2023 Mar 30; Vol. 51 (1), pp. 20. Date of Electronic Publication: 2023 Mar 30.

Severity detection tool for patients with infectious disease.

Autor: Tadesse GA; Institute of Biomedical Engineering, University of Oxford, Oxford, UK.; IBM Research | Africa, Nairobi, Kenya., Zhu T; Institute of Biomedical Engineering, University of Oxford, Oxford, UK., Le Nguyen Thanh N; Children's Hospital Number 1, Ho Chi Minh City, Vietnam., Hung NT; Children's Hospital Number 1, Ho Chi Minh City, Vietnam., Duong HTH; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Khanh TH; Children's Hospital Number 1, Ho Chi Minh City, Vietnam., Quang PV; Children's Hospital Number 1, Ho Chi Minh City, Vietnam., Tran DD; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Yen LM; Oxford Clinical Research Unit, Ho Chi Minh City, Vietnam., Doorn RV; Oxford University Clinical Research Unit, Hanoi, Vietnam.; Centre for Tropical Medicine and Global Health, Oxford University, UK., Hao NV; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Prince J; Institute of Biomedical Engineering, University of Oxford, Oxford, UK., Javed H; Institute of Biomedical Engineering, University of Oxford, Oxford, UK., Kiyasseh D; Institute of Biomedical Engineering, University of Oxford, Oxford, UK., Tan LV; Oxford Clinical Research Unit, Ho Chi Minh City, Vietnam., Thwaites L; Oxford Clinical Research Unit, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine and Global Health, Oxford University, UK., Clifton DA; Institute of Biomedical Engineering, University of Oxford, Oxford, UK.

Publikováno v: Healthcare technology letters [Healthc Technol Lett] 2020 Apr 14; Vol. 7 (2), pp. 45-50. Date of Electronic Publication: 2020 Apr 14 (Print Publication: 2020).

A Pilot Study to Assess Safety and Feasibility of Intrathecal Immunoglobulin for the Treatment of Adults with Tetanus.

Autor: Loan HT; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Yen LM; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Kestelyn E; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom.; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Hao NV; University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam.; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Mai NTH; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Thuy DB; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Duong HTH; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Dung NTP; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Phu NH; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Lieu PT; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Thanh TT; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Geskus R; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom.; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., van Doorn HR; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom.; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Tan LV; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Wyncoll D; Guy's and St. Thomas' Hospitals NHS Trust, London, United Kingdom., Day NPJ; Mahidol Oxford Research Unit, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom., Hien TT; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom.; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Thwaites GE; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom.; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Chau NVV; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Thwaites CL; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom.; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.

Publikováno v: The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2018 Aug; Vol. 99 (2), pp. 323-326. Date of Electronic Publication: 2018 Jun 14.