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Identification of CD8 + T-Cell-Immune Cell Communications in Ileal Crohn's Disease

Autor: Duong, Han G, Choi, Eunice J, Hsu, Paul, Chiang, Natalie R, Patel, Shefali A, Olvera, Jocelyn G, Liu, Yi Chia, Lin, Yun Hsuan, Yao, Priscilla, Wong, William H, Indralingam, Cynthia S, Tsai, Matthew S, Boland, Brigid S, Wang, Wei, Chang, John T

Publikováno v: Clinical and translational gastroenterology, vol 14, iss 5

IntroductionCrohn's disease (CD) is a major subtype of inflammatory bowel disease (IBD), a spectrum of chronic intestinal disorders caused by dysregulated immune responses to gut microbiota. Although transcriptional and functional changes in a number

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::2c59297a8d06957b59afd5d395e5864c
https://escholarship.org/uc/item/4cf0s3c5

Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of TH17 cell immunity

Autor: Lin, Chia-Hao, Wu, Cheng-Jang, Cho, Sunglim, Patkar, Rasika, Huth, William J., Lin, Ling-Li, Chen, Mei-Chi, Israelsson, Elisabeth, Betts, Joanne, Niedzielska, Magdalena, Patel, Shefali A., Duong, Han G., Gerner, Romana R., Hsu, Chia-Yun, Catley, Matthew, Maciewicz, Rose A., Chu, Hiutung, Raffatellu, Manuela, Chang, John T., Lu, Li-Fan

Publikováno v: Nature Immunology; 20230101, Issue: Preprints p1-13, 13p

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Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of Th17 immunity.

Autor: Lin CH; School of Biological Sciences, University of California, San Diego, La Jolla, California , CA, USA., Wu CJ; School of Biological Sciences, University of California, San Diego, La Jolla, California , CA, USA., Cho S; School of Biological Sciences, University of California, San Diego, La Jolla, California , CA, USA., Patkar R; School of Biological Sciences, University of California, San Diego, La Jolla, California , CA, USA., Lin LL; School of Biological Sciences, University of California, San Diego, La Jolla, California , CA, USA., Chen MC; School of Biological Sciences, University of California, San Diego, La Jolla, California , CA, USA., Israelsson E; Bioscience, Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Betts J; Bioscience, Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Niedzielska M; Bioscience, Research and Early Development, Respiratory & Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Patel SA; Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Duong HG; Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Gerner RR; Division of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Hsu CY; Department of Pathology, University of California San Diego, La Jolla, CA, USA., Catley M; Bioscience, Research and Early Development, Respiratory & Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Maciewicz RA; Bioscience, Research and Early Development, Respiratory & Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Chu H; Department of Pathology, University of California San Diego, La Jolla, CA, USA.; Chiba University-UC San Diego Center for Mucosal Immunology, Allergy, and Vaccines (CU-UCSD cMAV), La Jolla, CA 92093, USA.; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, USA., Raffatellu M; Division of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.; Chiba University-UC San Diego Center for Mucosal Immunology, Allergy, and Vaccines (CU-UCSD cMAV), La Jolla, CA 92093, USA.; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, USA., Chang JT; Department of Medicine, University of California, San Diego, La Jolla, CA, USA.; Department of Medicine, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA., Lu LF; School of Biological Sciences, University of California, San Diego, La Jolla, California , CA, USA.; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Feb 21. Date of Electronic Publication: 2023 Feb 21.