Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Duoli Sun"'
Autor:
Jieru Meng, Bingbing Dai, Bingliang Fang, B Nebiyou Bekele, William G Bornmann, Duoli Sun, Zhenghong Peng, Roy S Herbst, Vassiliki Papadimitrakopoulou, John D Minna, Michael Peyton, Jack A Roth
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e14124 (2010)
AZD6244 and MK2206 are targeted small-molecule drugs that inhibit MEK and AKT respectively. The efficacy of this combination in lung cancer is unknown. Our previous work showed the importance of activated AKT in mediating resistance of non-small cell
Externí odkaz:
https://doaj.org/article/5a2c9bf45d224b3b8e13b8bd8bb0bb5d
Autor:
Craig D. Logsdon, William G. Bornmann, David S. Maxwell, Ashutosh Pal, Zhenghong Peng, Duoli Sun, Vijaya Ramachandran, Thiruvengadam Arumugam
We have previously shown that the antiallergic drug cromolyn blocks S100P interaction with its receptor receptor for advanced glycation end product (RAGE) and improves gemcitabine effectiveness in pancreatic ductal adenocarcinoma (PDAC). However, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a7ef6c1d1b42e47dfd477752171d7c
https://doi.org/10.1158/1535-7163.c.6536146.v1
https://doi.org/10.1158/1535-7163.c.6536146.v1
Autor:
Craig D. Logsdon, William G. Bornmann, David S. Maxwell, Ashutosh Pal, Zhenghong Peng, Duoli Sun, Vijaya Ramachandran, Thiruvengadam Arumugam
PDF file - 124 KB, Synthesis of Cromolyn Analogs:Lead compound C5OH synthesis is presented in material and method sections. Other analogs synthesis procedure is provided as supplementary material.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e00cce3762c223a37062c2029fe4dd8
https://doi.org/10.1158/1535-7163.22499446.v1
https://doi.org/10.1158/1535-7163.22499446.v1
Autor:
Gilbert R. Lee, Florian L. Muller, John M. Asara, Todd M. Link, Federica Pisaneschi, Barbara Czako, Y. Alan Wang, Duoli Sun, William G. Bornmann, Yu Hsi Lin, Ronald A. DePinho, Paul G. Leonard, David Maxwell, Maria Emilia Di Francesco, Naima Hammoudi, Nikunj Satani, Basvoju A. Bhanu Prasad, Zhenghong Peng
Publikováno v:
Nature chemical biology
Despite being crucial for energy generation in most forms of life, few if any microbial antibiotics specifically inhibit glycolysis. To develop a specific inhibitor of the glycolytic enzyme enolase 2 (ENO2) for the treatment of cancers with deletion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7fe16601d682c58a159c49b4a33d58
https://doi.org/10.1038/nchembio.2195
https://doi.org/10.1038/nchembio.2195
Publikováno v:
Journal of the American Chemical Society. 128:9394-9407
The charge-resonance phenomenon originally identified by Badger and Brocklehurst lies at the core of the basic understanding of electron movement and delocalization that is possible within p-doped aromatic (face-to-face) arrays. To this end, we now u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a936fab718329c92e09ad4c54a9880d8
https://doi.org/10.1021/ja060393n
https://doi.org/10.1021/ja060393n
Publikováno v:
The Journal of Physical Chemistry A. 106:2283-2292
Intramolecular electron transfer in the organic mixed-valence cation radical D(ph)nD+• [where D = 2,5-dimethoxy-4-methylphenyl and (ph)n = poly-p-phenylene] is systematically probed by the structur...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1b32a9f676d5989d22a2c7965161bc0
https://doi.org/10.1021/jp012634d
https://doi.org/10.1021/jp012634d
Autor:
Ronald A. DePinho, Florian L. Muller, Paul G. Leonard, Joe Marszalek, Barbara Czako, Yuting Sun, Yu-Hsi Lin, Federica Pisaneschi, Duoli Sun, Zhenghong Peng, Ananth Bosajou, John S. McMurray, Naima Hammoudi, Nikunj Satani, Lee Iv R. Gilbert, Todd M. Link, Maria Emilia Di Francesco, David Maxwell, Pijus K. Mandal, Alan Wang, William G. Bornmann
Publikováno v:
Molecular Cancer Therapeutics. 16:A39-A39
Glycolysis inhibition is an active area of investigation for the treatment of cancer. However, few compounds have progressed beyond the cell culture stage. We have recently demonstrated that genomic passenger deletion of the glycolytic enzyme Enolase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1f8de6a4023203c42af31843ce70d37
https://doi.org/10.1158/1538-8514.synthleth-a39
https://doi.org/10.1158/1538-8514.synthleth-a39
Autor:
Basvoju A. Bhanu Prasad, Juri G. Gelovani, Duoli Sun, Zhenghong Peng, William G. Bornmann, Paul T. Schuber, Wai Kwan Alfred Yung, Yunming Ying, David Maxwell
Publikováno v:
Tetrahedron. 70(4)
A virtual library of 54 inositol analog mimics of In(1,4,5)P3 has been docked, scored, and ranked within the binding site of human inositol 1,4,5-trisphosphate 3-kinase A (IP3-3KA). Chemical synthesis of the best scoring structure that also met dista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a856450f659a9d060150f8365cd0010
https://pubmed.ncbi.nlm.nih.gov/25110363
https://pubmed.ncbi.nlm.nih.gov/25110363
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 2. :1585-1594
To study the mechanism of electronic transduction along (poly)phenylene chains, a series of aromatic donors with general formula D–B–D has been synthesized [where D = 2,5-dimethoxy-4-methylphenyl donor and B = (poly)phenylene bridge]; and the cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f43902e80b01a1c7cb45bd86d19b88d
https://doi.org/10.1039/b103139m
https://doi.org/10.1039/b103139m
Publikováno v:
Angewandte Chemie. 112:2207-2211
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd9ba0e248dd0b632d45224f4a9b759
https://doi.org/10.1002/1521-3757(20000616)112:12<2207::aid-ange2207>3.0.co
https://doi.org/10.1002/1521-3757(20000616)112:12<2207::aid-ange2207>3.0.co