Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Duohai Pan"'
Autor:
Yang Wu, Dieter M. Drexler, Joseph B. Santella, Thomas Brodie, Janet DiPiero, Stefan Ruepp, Umesh Hanumegowda, Brian Gemzik, Ching-Chiang Su, Evan B. Janovitz, Randy White, Michael J. Hageman, Julie Carman, John Hynes, Duohai Pan, John R. Megill
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 96:1-8
Introduction Low intrinsic solubility leading to poor oral bioavailability is a common challenge in drug discovery that can often be overcome by formulation strategies, however, it remains a potential limitation that can pose challenges for early ris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429b8bbd53417ba94dfbf17e20641c32
https://doi.org/10.1016/j.vascn.2018.12.003
https://doi.org/10.1016/j.vascn.2018.12.003
Autor:
Jinjiang Li, Duohai Pan
Publikováno v:
Protein Instability at Interfaces During Drug Product Development ISBN: 9783030571764
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e312c91385ed744803d64165760d0a2f
https://doi.org/10.1007/978-3-030-57177-1_13
https://doi.org/10.1007/978-3-030-57177-1_13
Autor:
Coleman Vaclaw, Neal Whitaker, Duohai Pan, Zhihua Liu, Mehrnaz Khossravi, Kimberly Merritt, Mark S. Bolgar, David B. Volkin, Gokhale Madhushree Yeshwant, Dilbir S. Bindra, Valerie Pringle, Prajnaparamita Dhar, Thiago C. Carvalho, Maria O. Ogunyankin
Publikováno v:
Journal of pharmaceutical sciences. 110(2)
Polysorbate 80 is a nonionic surfactant that is added to therapeutic protein formulations to mitigate protein particle formation when subjected to various mechanical stresses. Variations in the PS80 grade has recently sparked questions surrounding th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::907605d4abc31c5eee9409fc416b7566
https://pubmed.ncbi.nlm.nih.gov/32987092
https://pubmed.ncbi.nlm.nih.gov/32987092
Autor:
Otilia May Yue Koo, Sandeep Rana, Yongmei Wu, Duohai Pan, Partha Saha, Dinesh Morkhade, Junshu Zhao, Arturo Marin
Publikováno v:
The AAPS Journal. 19:1387-1395
In formulation development, certain excipients, even though used in small quantities, can have a significant impact on the processability and performance of the dosage form. In this study, three common disintegrants, croscarmellose sodium (CCS), cros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::262be1e7e01db7d94ceaf4788793e16a
https://doi.org/10.1208/s12248-017-0104-6
https://doi.org/10.1208/s12248-017-0104-6
Publikováno v:
Molecular Pharmaceutics. 14:377-385
A generalized screening approach, applying isothermal calorimetry at 37 °C 100% RH, to formulations of spray dried dispersions (SDDs) for two active pharmaceutical ingredients (APIs) (BMS-903452 and BMS-986034) is demonstrated. APIs 452 and 034, wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f88575f0b50119e992ee2411f70a780
https://doi.org/10.1021/acs.molpharmaceut.6b00722
https://doi.org/10.1021/acs.molpharmaceut.6b00722
Autor:
Tapan K. Das, Zhi Chen, Duohai Pan, Kaimeng Zhou, Gurusamy Balakrishnan, Ming Zeng, Sung-Joo Park
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 183
Monoclonal antibodies are heterogeneous in nature and may contain numerous variants with differences in size, charge, and hydrophobicity, which may impact clinical efficacy, immunogenicity, and safety. Characterization of antibody variants is necessa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78539b52bb60dfd5a807ce5fc5e9742e
https://pubmed.ncbi.nlm.nih.gov/32086124
https://pubmed.ncbi.nlm.nih.gov/32086124
Autor:
George Crull, Ipsit Kundu, Balvinder S. Vig, Varia Sailesh Amilal, Salil D. Desai, Hemant Bhutani, Narayana P. Swamy, Ravi P. Shah, Chiranjeevi Venkatesh, Sridhar Desikan, Sherif Badawy, Duohai Pan, Junshu Zhao
Publikováno v:
European Journal of Pharmaceutical Sciences. 152:105429
Poly (vinyl alcohol), PVA, a commonly used excipient to coat tablets, forms insoluble films in the presence of acids and thermal stress. This may lead to drug products failing to meet dissolution specifications over time. Studies were conducted to un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7342bd600a26df6c2dc7dfdf4415bb3f
https://doi.org/10.1016/j.ejps.2020.105429
https://doi.org/10.1016/j.ejps.2020.105429
Publikováno v:
AAPS PharmSciTech. 19(1)
Liquid crystal lipid-based formulations are an effective approach to prolong pharmacokinetics and reduce burst release of a drug on subcutaneous delivery. The objective of this paper was to investigate the influence of phase structures of a lipid-bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2073a5fb830d63ef3aab7c05fe61d896
https://pubmed.ncbi.nlm.nih.gov/28741139
https://pubmed.ncbi.nlm.nih.gov/28741139
Publikováno v:
Crystal Growth & Design. 14:5004-5010
A new crystalline polymorph (Form VIII) of the antidepressant drug aripiprazole has been discovered, resulting from a previously unknown enantiotropic phase transition from Form II at 225 K. This finding makes aripiprazole one of the most polymorphic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85e87ebb26d786f0b75bd7ce510862a6
https://doi.org/10.1021/cg500569x
https://doi.org/10.1021/cg500569x
Publikováno v:
Crystal Growth & Design. 13:2943-2952
The relative stabilities of crystalline polymorphs are an important aspect of the manufacturing and effective utilization of pharmaceuticals. These stabilities are driven by both molecular conformational energy within the solid-state components and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39235d6f054bb4c48c7b5c5bfe2f880e
https://doi.org/10.1021/cg400358e
https://doi.org/10.1021/cg400358e