Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Dunwiddie, Christopher T"'
Autor:
Daniel S. Mytelka, Stacy R. Lindborg, Steven M. Paul, Charles C. Persinger, Dunwiddie Christopher T, Bernard H. Munos, Aaron Leigh Schacht
Publikováno v:
Nature Reviews Drug Discovery. 9:203-214
The pharmaceutical industry is under growing pressure from a range of environmental issues, including major losses of revenue owing to patent expirations, increasingly cost-constrained healthcare systems and more demanding regulatory requirements. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::107c37d258f418caa427415eb5775803
https://doi.org/10.1038/nrd3078
https://doi.org/10.1038/nrd3078
Autor:
Karen Brown, W. Ewing, Ross G. Bentley, Mark H. Perrone, Christopher L. Heran, Robert J. Leadley, Jeffrey S. Bostwick, Charles Kasiewski, Suzanne R Morgan, Spada Alfred P, Dunwiddie Christopher T, Valeria Chu, Phillip Moxey, Pauls Henry W
Publikováno v:
Journal of Cardiovascular Pharmacology. 34:791-799
These studies were designed to examine the pharmacodynamic profile and antithrombotic efficacy of RPR120844, a competitive inhibitor of coagulation factor Xa, with a K(i) of 7 nM against human factor Xa. In vitro, RPR120844 doubled activated partial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb8cc715a3e27f800ed520f0de408258
https://doi.org/10.1097/00005344-199912000-00004
https://doi.org/10.1097/00005344-199912000-00004
Autor:
Charles J Kasiewski, Susan Morgan, Ross G. Bentley, Robert J. Leadley, Mark H Perrone, Jeffery Bostwick, Karen Brown, Dennis Colussi, Dunwiddie Christopher T, Yong Gong, Valeria Chu, Alison Zulli, Kevin Richard Guertin, Jingbo Gao, Pauls Henry W
Publikováno v:
Thrombosis research. 103(4)
FXV673 is a novel, potent, and selective factor Xa (FXa) inhibitor. FXV673 inhibited human, dog, and rabbit FXa with a K(i) of 0.52, 1.41, and 0.27 nM, respectively. FXV673 also displayed excellent specificity toward FXa relative to other serine prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffd6e818cfb51427655db2680df87076
https://pubmed.ncbi.nlm.nih.gov/11562341
https://pubmed.ncbi.nlm.nih.gov/11562341
Autor:
Sébastien Maignan, Davis Roderick S, Dunwiddie Christopher T, Michael R. Becker, William P. Dankulich, Karen Brown, Jean-Pierre Guilloteau, Mcgarry Daniel G, Daniel M. Green, Christopher L. Heran, Robert L. Morris, Robert J. Leadley, Spada Alfred P, Ross G. Bentley, William R. Ewing, Helen J. Mason, Valeria Chu, Y.M. Choi-Sledeski, Suzanne R Morgan, Daniel L. Cheney, Pauls Henry W, Dennis Colussi, Vincent E. Manetta
Publikováno v:
Journal of medicinal chemistry. 42(18)
Sulfonamidopyrrolidinones were previously disclosed as a selective class of factor Xa (fXa) inhibitors, culminating in the identification of RPR120844 as a potent member with efficacy in vivo. Recognizing the usefulness of the central pyrrolidinone t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816ed36d69dbaf13b89813b523b7aa90
https://pubmed.ncbi.nlm.nih.gov/10479289
https://pubmed.ncbi.nlm.nih.gov/10479289
Akademický článek
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Autor:
Czekaj, Mark, Klein, Scott I, Guertin, Kevin R, Gardner, Charles J, Zulli, Allison L, Pauls, Henry W, Spada, Alfred P, Cheney, Daniel L, Brown, Karen D, Colussi, Dennis J, Chu, Valeria, Leadley, Robert J, Dunwiddie, Christopher T
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2002 12(12):1667-1670
Autor:
Guertin, Kevin R, Gardner, Charles J, Klein, Scott I, Zulli, Allison L, Czekaj, Mark, Gong, Yong, Spada, Alfred P, Cheney, Daniel L, Maignan, Sebastian, Guilloteau, Jean-Pierre, Brown, Karen D, Colussi, Dennis J, Chu, Valeria, Heran, Christopher L, Morgan, Suzanne R, Bentley, Ross G, Dunwiddie, Christopher T, Leadley, Robert J, Pauls, Henry W
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2002 12(12):1671-1674
Autor:
Leadley Jr., Robert J., Morgan, Suzanne R., Bentley, Ross, Bostwick, Jeffrey S., Kasiewski, Charles J., Heran, Christopher, Chu, Valeria, Brown, Karen, Moxey, Phillip, Ewing, W. Richard, Pauls, Henry, Spada, Alfred P., Perrone, Mark H., Dunwiddie, Christopher T.
Publikováno v:
Journal of Cardiovascular Pharmacology; Dec1999, Vol. 34 Issue 6, p791-799, 9p
Autor:
Mellott, Michael J., Holahan, Marie A., Lynch, Joseph J., Vlasuk, George P., Dunwiddie, Christopher T.
Publikováno v:
Circulation Research; Jun1992, Vol. 70 Issue 6, p1152-1160, 9p
Autor:
Lynch, Joseph J, Sitko, Gary R, Mellott, Michael J, Nutt, Elka M, Lehman, E Dale, Friedman, Paul A, Dunwiddie, Christopher T, Vlasuk, George P
Publikováno v:
Cardiovascular Research; Jan1994, Vol. 28 Issue 1, p78-85, 8p