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Acute myeloid leukemia stratifies as two clinically relevant sphingolipidomic subtypes.

Autor: Paudel BB; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA., Tan SF; Department of Medicine, Division of Hematology & Oncology, University of Virginia, Charlottesville, VA., Fox TE; Department of Pharmacology, University of Virginia, Charlottesville, VA., Ung J; Department of Medicine, Division of Hematology & Oncology, University of Virginia, Charlottesville, VA.; Department of Microbiology, Immunology & Cancer Biology, University of Virginia, Charlottesville, VA., Shaw J; Department of Medicine, Division of Hematology & Oncology, University of Virginia, Charlottesville, VA., Dunton W; Department of Medicine, Division of Hematology & Oncology, University of Virginia, Charlottesville, VA., Lee I; Department of Medicine, Division of Hematology & Oncology, University of Virginia, Charlottesville, VA., Sharma A; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Cancer Institute, Hershey, PA., Viny AD; Departments of Medicine, Division of Hematology & Oncology, and of Genetics & Development, Columbia Stem Cell Initiative, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY., Barth BM; Department of Chemistry, Biology, and Health Sciences, South Dakota School of Mines and Technology, Rapid City, SD., Tallman MS; Northwestern University Feinberg School of Medicine Robert H. Lurie Comprehensive Cancer Center Chicago, IL., Cabot M; Department of Biochemistry & Molecular Biology, Brody School of Medicine, and the East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC., Garrett-Bakelman FE; Department of Medicine, Division of Hematology & Oncology, University of Virginia, Charlottesville, VA.; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA.; University of Virginia Comprehensive Cancer Center, Charlottesville, VA., Levine RL; Human Oncology and Pathogenesis Program and Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Kester M; Department of Pharmacology, University of Virginia, Charlottesville, VA.; University of Virginia Comprehensive Cancer Center, Charlottesville, VA., Claxton D; Penn State Cancer Institute, Hershey, PA.; Department of Medicine, Division of Hematology and Oncology, Pennsylvania State University College of Medicine, Hershey, PA., Feith DJ; Department of Medicine, Division of Hematology & Oncology, University of Virginia, Charlottesville, VA.; University of Virginia Comprehensive Cancer Center, Charlottesville, VA., Janes KA; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA.; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA.; University of Virginia Comprehensive Cancer Center, Charlottesville, VA., Loughran TP Jr; Department of Medicine, Division of Hematology & Oncology, University of Virginia, Charlottesville, VA.; University of Virginia Comprehensive Cancer Center, Charlottesville, VA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Apr 17. Date of Electronic Publication: 2023 Apr 17.