Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes : A Large-Scale Cross-Consortium Mendelian Randomization Study

Autor: Prins, Bram P., Abbasi, Ali, Wong, Anson, Vaez, Ahmad, Nolte, Ilja, Franceschini, Nora, Stuart, Philip E., Guterriez Achury, Javier, Mistry, Vanisha, Bradfield, Jonathan P., Valdes, Ana M., Bras, Jose, Shatunov, Aleksey, Lu, Chen, Han, Buhm, Raychaudhuri, Soumya, Bevan, Steve, Mayes, Maureen D., Tsoi, Lam C., Evangelou, Evangelos, Nair, Rajan P., Grant, Struan F. A., Polychronakos, Constantin, Radstake, Timothy R. D., van Heel, David A., Dunstan, Melanie L., Wood, Nicholas W., Al-Chalabi, Ammar, Dehghan, Abbas, Hakonarson, Hakon, Markus, Hugh S., Elder, James T., Knight, Jo, Arking, Dan E., Spector, Timothy D., Koeleman, Bobby P. C., van Duijn, Cornelia M., Martin, Javier, Morris, Andrew P., Weersma, Rinse K., Wijmenga, Cisca, Munroe, Patricia B., Perry, John R. B., Pouget, Jennie G., Jamshidi, Yalda, Snieder, Harold, Alizadeh, Behrooz Z., Williams, Julie, PAGE Consortium, International Stroke Genetics Consortium, Systemic Sclerosis consortium, Treat OA consortium, DIAGRAM Consortium, CARDIoGRAMplusC4D Consortium, ALS consortium, International Parkinson’s Disease Genomics Consortium, Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, CKDGen consortium, GERAD1 Consortium, International Consortium for Blood Pressure, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Inflammation Working Group of the CHARGE Consortium

Publikováno v: PLOS MEDICINE, 13(6):e1001976. PUBLIC LIBRARY SCIENCE
Prins, B P, Abbasi, A, Wong, A, Vaez, A, Nolte, I, Franceschini, N, Stuart, P E, Guterriez Achury, J, Mistry, V, Bradfield, J P, Valdes, A M, Bras, J, Shatunov, A, Lu, C, Han, B, Raychaudhuri, S, Bevan, S, Mayes, M D, Tsoi, L C, Evangelou, E, Nair, R P, Grant, S F A, Polychronakos, C, Radstake, T R D, van Heel, D A, Dunstan, M L, Wood, N W, Al-Chalabi, A, Dehghan, A, Hakonarson, H, Markus, H S, Elder, J T, Knight, J, Arking, D E, Spector, T D, Koeleman, B P C, van Duijn, C M, Martin, J, Morris, A P, Weersma, R K, Wijmenga, C, Munroe, P B, Perry, J R B, Pouget, J G, Jamshidi, Y, Snieder, H, Alizadeh, B Z 2016, ' Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes : A Large-Scale Cross-Consortium Mendelian Randomization Study ', PL o S Medicine, vol. 13, no. 6, e1001976 . https://doi.org/10.1371/journal.pmed.1001976, https://doi.org/10.1371/journal.pmed.1001976
Prins, B P, Abbasi, A, Wong, A, Vaez, A, Nolte, I, Franceschini, N, Stuart, P E, Guterriez Achury, J, Mistry, V, Bradfield, J P, Valdes, A M, Bras, J, Shatunov, A, Lu, C, Han, B, Raychaudhuri, S, Bevan, S, Mayes, M D, Tsoi, L C, Evangelou, E, Nair, R P, Grant, S F A, Polychronakos, C, Radstake, T R D, van Heel, D A, Dunstan, M L, Wood, N W, Al-Chalabi, A, Dehghan, A, Hakonarson, H, Markus, H S, Elder, J T, Knight, J, Arking, D E, Spector, T D, Koeleman, B P C, van Duijn, C M, Martin, J, Morris, A P, Weersma, R K, Wijmenga, C, Munroe, P B, Perry, J R B, Pouget, J G, Jamshidi, Y, Snieder, H, Alizadeh, B Z & PAGE Consortium 2016, ' Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study ', PL o S Medicine, vol. 13, no. 6, pp. e1001976 . https://doi.org/10.1371/journal.pmed.1001976
PLOS MEDICINE
PLoS Medicine
PLoS Medicine, 13(6). Public Library of Science
PLoS Medicine, Vol 13, Iss 6, p e1001976 (2016)
PLoS Medicine (online), 13(6):e1001976. Public Library of Science

Background C-reactive protein (CRP) is associated with immune, cardiometabolic, and psychiatric traits and diseases. Yet it is inconclusive whether these associations are causal. Methods and Findings We performed Mendelian randomization (MR) analyses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d894bc9af149d32ba1f8b30ef206685
https://hdl.handle.net/1874/342989

Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease

Autor: Escott-Price, Valentina, Bellenguez, Céline, DeStefano, Anita L, Galimberti, Daniela, Scarpini, Elio, Bonuccelli, Ubaldo, Mancuso, Michelangelo, Siciliano, Gabriele, Moebus, Susanne, Mecocci, Patrizia, Zompo, Maria Del, Maier, Wolfgang, Hampel, Harald, Lambert, Jean-Charles, Pilotto, Alberto, Frank-García, Ana, Panza, Francesco, Solfrizzi, Vincenzo, Caffarra, Paolo, Nacmias, Benedetta, Perry, William, Mayhaus, Manuel, Lannfelt, Lars, Hakonarson, Hakon, Ibrahim-Verbaas, Carla A, Pichler, Sabrina, Carrasquillo, Minerva M, Ingelsson, Martin, Beekly, Duane, Alvarez, Victoria, Zou, Fanggeng, Valladares, Otto, Younkin, Steven G, Coto, Eliecer, Hamilton-Nelson, Kara L, Naj, Adam C, Gu, Wei, Razquin, Cristina, Pastor, Pau, Mateo, Ignacio, Owen, Michael J, Faber, Kelley M, Jonsson, Palmi V, Combarros, Onofre, O'Donovan, Michael C, Cantwell, Laura B, Sims, Rebecca, Soininen, Hilkka, Blacker, Deborah, Mead, Simon, Mosley, Thomas H, Bennett, David A, Harris, Tamara B, Fratiglioni, Laura, Holmes, Clive, de Bruijn, Renee F A G, Passmore, Peter, Jun, Gyungah, Montine, Thomas J, Bettens, Karolien, Rotter, Jerome I, Brice, Alexis, Morgan, Kevin, Foroud, Tatiana M, Kukull, Walter A, Hannequin, Didier, Powell, John F, Nalls, Michael A, Bis, Joshua C, Ritchie, Karen, Lunetta, Kathryn L, Kauwe, John S K, Boerwinkle, Eric, Riemenschneider, Matthias, Boada, Mercè, Hiltunen, Mikko, Martin, Eden R, Schmidt, Reinhold, Rujescu, Dan, Beecham, Gary W, Dartigues, Jean-François, Mayeux, Richard, Tzourio, Christophe, Hofman, Albert, Nöthen, Markus M, Graff, Caroline, Psaty, Bruce M, Haines, Jonathan L, Lathrop, Mark, Pericak-Vance, Margaret A, Grenier-Boley, Benjamin, Launer, Lenore J, Van Broeckhoven, Christine, Farrer, Lindsay A, van Duijn, Cornelia M, Ramirez, Alfredo, Seshadri, Sudha, Schellenberg, Gerard D, Amouyel, Philippe, Williams, Julie, Study, Cardiovascular Health, Russo, Giancarlo, Olson, Jean, Kronmal, Richard, Arnold, Alice M, Robbins, John, Carlson, Michelle, Burke, Gregory, Kuller, Lewis H, Tracy, Russell, Gottdiener, John, Prineas, Ronald, Wang, Li-San, Thornton-Wells, Tricia A, Becker, James T, Enright, Paul, Klein, Ronald, O'Leary, Daniel H, Denning, Nicola, Smith, Albert V, Chouraki, Vincent, Thomas, Charlene, Ikram, M Arfan, Zelenika, Diana, Vardarajan, Badri N, Kamatani, Yoichiro, Lin, Chiao-Feng, Choi, Seung-Hoan, Schmidt, Helena, Kunkle, Brian, Dunstan, Melanie L, Vronskaya, Maria, Consortium, United Kingdom Brain Expression, Johnson, Andrew D, Ruiz, Agustin, Bihoreau, Marie-Thérèse, Reitz, Christiane, Pasquier, Florence, Harold, Denise, Hollingworth, Paul, Hanon, Olivier, Fitzpatrick, Annette L, Buxbaum, Joseph D, Campion, Dominique, Crane, Paul K, Baldwin, Clinton, Becker, Tim, Gudnason, Vilmundur, Cruchaga, Carlos, Jones, Lesley, Craig, David, Amin, Najaf, Berr, Claudine, Lopez, Oscar L, De Jager, Philip L, Deramecourt, Vincent, Johnston, Janet A, Evans, Denis, Lovestone, Simon, Letenneur, Luc, Holmans, Peter, Hernández, Isabel, Rubinsztein, David C, Eiriksdottir, Gudny, Sleegers, Kristel, Goate, Alison M, Fiévet, Nathalie, Huentelman, Matthew J, Gill, Michael, Brown, Kristelle, Kamboh, M Ilyas, Gerrish, Amy, Keller, Lina, Barberger-Gateau, Pascale, McGuinness, Bernadette, Larson, Eric B, Myers, Amanda J, Dufouil, Carole, Todd, Stephen, Wallon, David, Love, Seth, Rogaeva, Ekaterina, Vedernikov, Alexey, Gallacher, John, George-Hyslop, Peter St, Clarimon, Jordi, Lleo, Alberto, Bayer, Anthony, Tsuang, Debby W, Yu, Lei, Tsolaki, Magda, Bossù, Paola, Spalletta, Gianfranco, Richards, Alexander, Proitsi, Petra, Collinge, John, Sorbi, Sandro, Garcia, Florentino Sanchez, Fox, Nick C, Hardy, John, Naranjo, Maria Candida Deniz, Bosco, Paolo, Clarke, Robert, Brayne, Carol

Publikováno v: PLoS One (print), 9(6). Public Library of Science
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
PLoS One. 2014 Jun 12;9(6):e94661
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
PLoS ONE, Vol 9, Iss 6, p e94661 (2014)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC
PLoS ONE
PLoS One
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
PLOS ONE 9(6), e94661 (2014). doi:10.1371/journal.pone.0094661

Background: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, usi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8d68243634f4f4d3d07b6e1bd04d102
http://hdl.handle.net/11391/1314148

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INVESTIGATING THE EFFECT OF MULTIPLE GENES ON CELLULAR PROCESSES IMPLICATED IN LATE ONSET ALZHEIMER’S DISEASE

Autor: Barrett, Anna N., Dunstan, Melanie L., Thomas, Rhian S., Kidd, Emma J., Jones, Lesley, Williams, Julie

Publikováno v: In Alzheimer's & Dementia: The Journal of the Alzheimer's Association July 2016 12(7) Supplement:P457-P457

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