Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma.

Autor: He C; Department of Developmental Neurobiology, Memphis, TN, USA., Xu K; Center for Applied Bioinformatics, Memphis, TN, USA.; Department of Computational Biology, Memphis, TN, USA., Zhu X; Department of Developmental Neurobiology, Memphis, TN, USA., Dunphy PS; Department of Developmental Neurobiology, Memphis, TN, USA.; Department of Oncology, Memphis, TN, USA., Gudenas B; Department of Developmental Neurobiology, Memphis, TN, USA., Lin W; Department of Chemical Biology and Therapeutics, Memphis, TN, USA., Twarog N; Department of Chemical Biology and Therapeutics, Memphis, TN, USA., Hover LD; Department of Developmental Neurobiology, Memphis, TN, USA., Kwon CH; Department of Developmental Neurobiology, Memphis, TN, USA., Kasper LH; Department of Developmental Neurobiology, Memphis, TN, USA., Zhang J; Department of Developmental Neurobiology, Memphis, TN, USA., Li X; Department of Pathology, Memphis, TN, USA., Dalton J; Department of Pathology, Memphis, TN, USA., Jonchere B; Department of Tumor Cell Biology, Memphis, TN, USA., Mercer KS; Department of Tumor Cell Biology, Memphis, TN, USA., Currier DG; Department of Chemical Biology and Therapeutics, Memphis, TN, USA., Caufield W; Preclinical Pharmacokinetics Shared Resource St. Jude Children's Research Hospital, Memphis, TN, USA., Wang Y; Preclinical Pharmacokinetics Shared Resource St. Jude Children's Research Hospital, Memphis, TN, USA., Xie J; Department of Chemical Biology and Therapeutics, Memphis, TN, USA., Broniscer A; Division of Hematology-Oncology, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA., Wetmore C; Exelixis, Inc., Alameda, CA, USA., Upadhyaya SA; Department of Oncology, Memphis, TN, USA., Qaddoumi I; Department of Oncology, Memphis, TN, USA., Klimo P; Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN, USA., Boop F; Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN, USA., Gajjar A; Department of Oncology, Memphis, TN, USA., Zhang J; Department of Computational Biology, Memphis, TN, USA., Orr BA; Department of Pathology, Memphis, TN, USA., Robinson GW; Department of Oncology, Memphis, TN, USA., Monje M; Department of Neurology, Stanford University, Stanford, CA, USA., Freeman Iii BB; Preclinical Pharmacokinetics Shared Resource St. Jude Children's Research Hospital, Memphis, TN, USA., Roussel MF; Department of Tumor Cell Biology, Memphis, TN, USA., Northcott PA; Department of Developmental Neurobiology, Memphis, TN, USA., Chen T; Department of Chemical Biology and Therapeutics, Memphis, TN, USA., Rankovic Z; Department of Chemical Biology and Therapeutics, Memphis, TN, USA., Wu G; Center for Applied Bioinformatics, Memphis, TN, USA.; Department of Computational Biology, Memphis, TN, USA., Chiang J; Department of Pathology, Memphis, TN, USA. Suzanne.Baker@StJude.org., Tinkle CL; Department of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA. Anang.Shelat@StJude.org., Shelat AA; Department of Chemical Biology and Therapeutics, Memphis, TN, USA. Christopher.Tinkle@StJude.org., Baker SJ; Department of Developmental Neurobiology, Memphis, TN, USA. Jason.Chiang@StJude.org.

Publikováno v: Nature communications [Nat Commun] 2021 Jul 02; Vol. 12 (1), pp. 4089. Date of Electronic Publication: 2021 Jul 02.

Ehrlichia chaffeensis TRP120 Effector Targets and Recruits Host Polycomb Group Proteins for Degradation To Promote Intracellular Infection.

Autor: Mitra S; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA., Dunphy PS; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA., Das S; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA., Zhu B; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA., Luo T; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA., McBride JW; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA jemcbrid@utmb.edu.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.; Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, USA.; Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, Texas, USA.; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, USA.

Publikováno v: Infection and immunity [Infect Immun] 2018 Mar 22; Vol. 86 (4). Date of Electronic Publication: 2018 Mar 22 (Print Publication: 2018).

Ehrlichia chaffeensis TRP32 is a Nucleomodulin that Directly Regulates Expression of Host Genes Governing Differentiation and Proliferation.

Autor: Farris TR; Departments of Microbiology and Immunology and Pathology., Dunphy PS; Departments of Microbiology and Immunology and Pathology., Zhu B; Departments of Microbiology and Immunology and Pathology., Kibler CE; Departments of Microbiology and Immunology and Pathology., McBride JW; Departments of Microbiology and Immunology and Pathology Departments of Microbiology and Immunology and Pathology Center for Biodefense and Emerging Infectious Diseases Sealy Center for Vaccine Development Institute for Human Infections and Immunity , University of Texas Medical Branch, Galveston, TX jemcbrid@utmb.edu.

Publikováno v: Infection and immunity [Infect Immun] 2016 Nov; Vol. 84 (11), pp. 3182-3194. Date of Electronic Publication: 2016 Aug 29.

Ehrlichia chaffeensis Exploits Canonical and Noncanonical Host Wnt Signaling Pathways To Stimulate Phagocytosis and Promote Intracellular Survival.

Autor: Luo T; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA., Dunphy PS; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA., Lina TT; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA., McBride JW; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, USA Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, Texas, USA Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, USA jemcbrid@utmb.edu.

Publikováno v: Infection and immunity [Infect Immun] 2015 Dec 28; Vol. 84 (3), pp. 686-700. Date of Electronic Publication: 2015 Dec 28.

Ehrlichia moonlighting effectors and interkingdom interactions with the mononuclear phagocyte.

Autor: Dunphy PS; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA., Luo T, McBride JW

Publikováno v: Microbes and infection [Microbes Infect] 2013 Dec; Vol. 15 (14-15), pp. 1005-16. Date of Electronic Publication: 2013 Oct 18.