Enhanced Characterization of Lysine-Linked Antibody Drug Conjugates Enabled by Middle-Down Mass Spectrometry and Higher-Energy Collisional Dissociation-Triggered Electron-Transfer/Higher-Energy Collisional Dissociation and Ultraviolet Photodissociation.

Autor: Watts, Eleanor, Bashyal, Aarti, Dunham, Sean D., Crittenden, Christopher M., Brodbelt, Jennifer S.

Publikováno v: Antibodies (2073-4468); Jun2024, Vol. 13 Issue 2, p30, 18p

Enhancing Top-Down Analysis of Proteins by Combining Ultraviolet Photodissociation (UVPD), Proton-Transfer Charge Reduction (PTCR), and Gas-Phase Fractionation to Alleviate the Impact of Nondissociated Precursor Ions.

Autor: Dunham, Sean D.¹ (AUTHOR), Brodbelt, Jennifer S.¹ (AUTHOR) jbrodbelt@cm.utexas.edu

Publikováno v: Journal of the American Society for Mass Spectrometry. 2/7/2024, Vol. 35 Issue 2, p255-265. 11p.

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Improving the Center Section Sequence Coverage of Large Proteins Using Stepped-Fragment Ion Protection Ultraviolet Photodissociation.

Autor: Dunham SD; Department of Chemistry, University of Texas, Austin, Texas 78712, United States., Sanders JD; Department of Chemistry, University of Texas, Austin, Texas 78712, United States., Holden DD; Department of Chemistry, University of Texas, Austin, Texas 78712, United States., Brodbelt JS; Department of Chemistry, University of Texas, Austin, Texas 78712, United States.

Publikováno v: Journal of the American Society for Mass Spectrometry [J Am Soc Mass Spectrom] 2022 Mar 02; Vol. 33 (3), pp. 446-456. Date of Electronic Publication: 2022 Feb 04.