A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.

Autor: Coll RC; 1] School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. [2] Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia., Robertson AA; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia., Chae JJ; Inflammatory Disease Section, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Higgins SC; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Muñoz-Planillo R; Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, USA., Inserra MC; 1] Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia. [2] School of Pharmacy, University of Queensland, Brisbane, Australia., Vetter I; 1] Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia. [2] School of Pharmacy, University of Queensland, Brisbane, Australia., Dungan LS; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Monks BG; Institute of Innate Immunity, University Hospital, University of Bonn, Bonn, Germany., Stutz A; Institute of Innate Immunity, University Hospital, University of Bonn, Bonn, Germany., Croker DE; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia., Butler MS; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia., Haneklaus M; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Sutton CE; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Núñez G; Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, USA., Latz E; 1] Institute of Innate Immunity, University Hospital, University of Bonn, Bonn, Germany. [2] Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA. [3] German Center for Neurodegenerative Diseases, Bonn, Germany., Kastner DL; Inflammatory Disease Section, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Mills KH; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Masters SL; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia., Schroder K; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia., Cooper MA; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia., O'Neill LA; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

Publikováno v: Nature medicine [Nat Med] 2015 Mar; Vol. 21 (3), pp. 248-55. Date of Electronic Publication: 2015 Feb 16.

Blocking retinoic acid receptor-α enhances the efficacy of a dendritic cell vaccine against tumours by suppressing the induction of regulatory T cells.

Autor: Galvin KC; Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, 152-160 Pearse St, Dublin 2, Ireland., Dyck L, Marshall NA, Stefanska AM, Walsh KP, Moran B, Higgins SC, Dungan LS, Mills KH

Publikováno v: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2013 Jul; Vol. 62 (7), pp. 1273-82. Date of Electronic Publication: 2013 May 09.

The role of inflammasome-derived IL-1 in driving IL-17 responses.

Autor: Mills KH; Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. kingston.mills@tcd.ie, Dungan LS, Jones SA, Harris J

Publikováno v: Journal of leukocyte biology [J Leukoc Biol] 2013 Apr; Vol. 93 (4), pp. 489-97. Date of Electronic Publication: 2012 Dec 27.

IL-27 mediates the response to IFN-β therapy in multiple sclerosis patients by inhibiting Th17 cells.

Autor: Sweeney CM; School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland., Lonergan R, Basdeo SA, Kinsella K, Dungan LS, Higgins SC, Kelly PJ, Costelloe L, Tubridy N, Mills KH, Fletcher JM

Publikováno v: Brain, behavior, and immunity [Brain Behav Immun] 2011 Aug; Vol. 25 (6), pp. 1170-81. Date of Electronic Publication: 2011 Mar 21.