Zobrazeno 1 - 10
of 1 040
pro vyhledávání: '"Dung N"'
Autor:
Jérémie Prévost, Yaozong Chen, Fei Zhou, William D. Tolbert, Romain Gasser, Halima Medjahed, Manon Nayrac, Dung N. Nguyen, Suneetha Gottumukkala, Ann J. Hessell, Venigalla B. Rao, Edwin Pozharski, Rick K. Huang, Doreen Matthies, Andrés Finzi, Marzena Pazgier
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The HIV-1 entry inhibitor temsavir prevents the viral receptor CD4 (cluster of differentiation 4) from interacting with the envelope glycoprotein (Env) and blocks its conformational changes. To do this, temsavir relies on the presence of a r
Externí odkaz:
https://doaj.org/article/5ca0ee97820f4768be0d20e9dea09bbe
Autor:
William D. Tolbert, Yaozong Chen, Lulu Sun, Mehdi Benlarbi, Shilei Ding, Rohini Manickam, Emily Pangaro, Dung N. Nguyen, Suneetha Gottumukkala, Marceline Côté, Frank J. Gonzalez, Andrés Finzi, Zahra R. Tehrani, Mohammad M. Sajadi, Marzena Pazgier
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
SARS-CoV-2, the virus behind the COVID-19 pandemic, has changed over time to the extent that the current virus is substantially different from what originally led to the pandemic in 2019–2020. Viral variants have modified the severity and transmiss
Externí odkaz:
https://doaj.org/article/b258916f21c94cc0b4e0c87d505b8f25
Publikováno v:
IEEE Access, Vol 10, Pp 110727-110741 (2022)
Advances in reinforcement learning (RL) algorithms have made them become increasingly capable in many tasks in recent years. However, the vast majority of RL algorithms are not readily interpretable off the shelf. Moreover, the task of generating exp
Externí odkaz:
https://doaj.org/article/5be0a63419d84bec879f8945113bb8d5
Autor:
Yaozong Chen, Jérémie Prévost, Irfan Ullah, Hugo Romero, Veronique Lisi, William D. Tolbert, Jonathan R. Grover, Shilei Ding, Shang Yu Gong, Guillaume Beaudoin-Bussières, Romain Gasser, Mehdi Benlarbi, Dani Vézina, Sai Priya Anand, Debashree Chatterjee, Guillaume Goyette, Michael W. Grunst, Ziwei Yang, Yuxia Bo, Fei Zhou, Kathie Béland, Xiaoyun Bai, Allison R. Zeher, Rick K. Huang, Dung N. Nguyen, Rebekah Sherburn, Di Wu, Grzegorz Piszczek, Bastien Paré, Doreen Matthies, Di Xia, Jonathan Richard, Priti Kumar, Walther Mothes, Marceline Côté, Pradeep D. Uchil, Vincent-Philippe Lavallée, Martin A. Smith, Marzena Pazgier, Elie Haddad, Andrés Finzi
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105783- (2023)
Summary: Neutralizing antibodies (NAbs) hold great promise for clinical interventions against SARS-CoV-2 variants of concern (VOCs). Understanding NAb epitope-dependent antiviral mechanisms is crucial for developing vaccines and therapeutics against
Externí odkaz:
https://doaj.org/article/4347d7b5ecc4456ca4f762f55082f32d
Autor:
William D. Tolbert, Neelakshi Gohain, Paul G. Kremer, Andrew P. Hederman, Dung N. Nguyen, Verna Van, Rebekah Sherburn, George K. Lewis, Andrés Finzi, Justin Pollara, Margaret E. Ackerman, Adam W. Barb, Marzena Pazgier
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Fc mediated effector functions of antibodies play important roles in immunotherapies and vaccine efficacy but assessing those functions in animal models can be challenging due to species differences. Rhesus macaques, Macaca mulatta (Mm) share approxi
Externí odkaz:
https://doaj.org/article/35ba42702de84fb390327cdf58ef34a5
Autor:
William D. Tolbert, Dung N. Nguyen, Marina Tuyishime, Andrew R. Crowley, Yaozong Chen, Shalini Jha, Derrick Goodman, Valerie Bekker, Sarah V. Mudrak, Anthony L. DeVico, George K. Lewis, James F. Theis, Abraham Pinter, M. Anthony Moody, David Easterhoff, Kevin Wiehe, Justin Pollara, Kevin O. Saunders, Georgia D. Tomaras, Margaret Ackerman, Guido Ferrari, Marzena Pazgier
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Passive transfer of monoclonal antibodies (mAbs) of human origin into Non-Human Primates (NHPs), especially those which function predominantly by a Fc-effector mechanism, requires an a priori preparation step, in which the human mAb is reengineered t
Externí odkaz:
https://doaj.org/article/ebe45cad4e6d401b8cdeec5671af1e07
Autor:
Alice W. Lee, Wura Jacobs, Michelle Tran, Becky Nguyen, Dung N. Hua, John N. Ho, Thai Van Nguyen
Publikováno v:
PLoS ONE, Vol 17, Iss 9 (2022)
Background Prevalence of hepatitis C virus (HCV) infection among Vietnamese Americans is reportedly high. Understanding the profile of those at greater risk of HCV in this ethnic population is a vital step to addressing this high prevalence. We hypot
Externí odkaz:
https://doaj.org/article/5b9d736bb018459ababd3995a3ff7fce
Autor:
Jonathan Richard, Dung N. Nguyen, William D. Tolbert, Romain Gasser, Shilei Ding, Dani Vézina, Shang Yu Gong, Jérémie Prévost, Gabrielle Gendron-Lepage, Halima Medjahed, Suneetha Gottumukkala, Andrés Finzi, Marzena Pazgier
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
Highly conserved epitopes within the coreceptor binding site (CoRBS) and constant region 1 and 2 (C1-C2 or cluster A) are only available for antibody recognition after the HIV-1 Env trimer binds host cell CD4; therefore, they are not accessible on vi
Externí odkaz:
https://doaj.org/article/f9c7bceebbc243d6b3de645a7dec77d2
Autor:
William D. Tolbert, Dung N. Nguyen, Zahra Rikhtegaran Tehrani, Mohammad M. Sajadi, Marzena Pazgier
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT The first step in HIV-1 entry is the attachment of the envelope (Env) trimer to target cell CD4. As such, the CD4-binding site (CD4bs) remains one of the few universally accessible sites for antibodies (Abs). We recently described a method o
Externí odkaz:
https://doaj.org/article/4c4bf6fd90634ed7ab385dfa192c5010
Autor:
Dung N. Nguyen, Bokai Xu, Robyn L. Stanfield, Jennifer K. Bailey, Satoru Horiya, J. Sebastian Temme, Deborah R. Leon, Celia C. LaBranche, David C. Montefiori, Catherine E. Costello, Ian A. Wilson, Isaac J. Krauss
Publikováno v:
ACS Central Science, Vol 5, Iss 2, Pp 237-249 (2019)
Externí odkaz:
https://doaj.org/article/9f4707366b53402dbecdc17a9b42eefa