Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Dung Fang Lee"'
Autor:
Sandhya Malla, Kanchan Kumari, Carlos A. García-Prieto, Jonatan Caroli, Anna Nordin, Trinh T. T. Phan, Devi Prasad Bhattarai, Carlos Martinez-Gamero, Eshagh Dorafshan, Stephanie Stransky, Damiana Álvarez-Errico, Paulina Avovome Saiki, Weiyi Lai, Cong Lyu, Ludvig Lizana, Jonathan D. Gilthorpe, Hailin Wang, Simone Sidoli, Andre Mateus, Dung-Fang Lee, Claudio Cantù, Manel Esteller, Andrea Mattevi, Angel-Carlos Roman, Francesca Aguilo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Lysine-specific histone demethylase 1 (LSD1), which demethylates mono- or di- methylated histone H3 on lysine 4 (H3K4me1/2), is essential for early embryogenesis and development. Here we show that LSD1 is dispensable for mouse embryonic stem
Externí odkaz:
https://doaj.org/article/2d6f847ecfc84532b688deb0fc0250d8
Publikováno v:
Cancers, Vol 16, Iss 8, p 1558 (2024)
The retinoblastoma (RB) transcriptional corepressor 1 (RB1) is a critical tumor suppressor gene, governing diverse cellular processes implicated in cancer biology. Dysregulation or deletion in RB1 contributes to the development and progression of var
Externí odkaz:
https://doaj.org/article/81fb008f0aa748ddacca94131b0c81be
Autor:
An Xu, Mo Liu, Mo-Fan Huang, Yang Zhang, Ruifeng Hu, Julian A. Gingold, Ying Liu, Dandan Zhu, Chian-Shiu Chien, Wei-Chen Wang, Zian Liao, Fei Yuan, Chih-Wei Hsu, Jian Tu, Yao Yu, Taylor Rosen, Feng Xiong, Peilin Jia, Yi-Ping Yang, Danielle A. Bazer, Ya-Wen Chen, Wenbo Li, Chad D. Huff, Jay-Jiguang Zhu, Francesca Aguilo, Shih-Hwa Chiou, Nathan C. Boles, Chien-Chen Lai, Mien-Chie Hung, Zhongming Zhao, Eric L. Van Nostrand, Ruiying Zhao, Dung-Fang Lee
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
The dysregulation of the m6A epitranscriptomic networks have been reported to contribute to the development of gliomas. Here, the authors utilize induced pluripotent stem cell-derived astrocytes with a p53 mutation and demonstrate that mutant p53 upr
Externí odkaz:
https://doaj.org/article/e94f230ab56e49dfb83c91e1ccf71c9f
Autor:
Jaskirat Singh Batra, Ting-Yen Chi, Mo-Fan Huang, Dandan Zhu, Zheyuan Chen, Dung-Fang Lee, Jun Kameoka
Publikováno v:
Biosensors, Vol 13, Iss 9, p 861 (2023)
The coronavirus disease (COVID-19) pandemic has increased pressure to develop low-cost, compact, user-friendly, and ubiquitous virus sensors for monitoring infection outbreaks in communities and preventing economic damage resulting from city lockdown
Externí odkaz:
https://doaj.org/article/aaef9a921e7e43a09aabb83ab50c0e61
Publikováno v:
Stem Cell Research, Vol 63, Iss , Pp 102845- (2022)
Copper transporter 1 (CTR1) is the major membrane protein responsible for cellular copper (Cu) uptake and mediates cellular copper homeostasis. To elucidate CTR1′s behavior using imaging approaches, we generated a homozygous knock-in human embryoni
Externí odkaz:
https://doaj.org/article/3844ec0982974313932e3f9d46251184
Autor:
Hong-Bo Li, Gang Huang, Jian Tu, Dong-Ming Lv, Qing-Lin Jin, Jun-Kai Chen, Yu-Tong Zou, Dung-Fang Lee, Jing-Nan Shen, Xian-Biao Xie
Publikováno v:
EBioMedicine, Vol 82, Iss , Pp 104142- (2022)
Summary: Background: Osteosarcoma (OS) is the most common primary malignant bone tumor in adolescents. The molecular mechanism behind OS progression and metastasis remains poorly understood, which limits the effectiveness of current therapies. RNA N6
Externí odkaz:
https://doaj.org/article/ac1260129e30429c85108cf29fe8ec08
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 21, Iss , Pp 180-191 (2020)
Long non-coding RNAs (lncRNAs) have recently been found to be important in gene regulation. lncRNA H19 has been reported to play an oncogenic role in many human cancers. Its specific regulatory role is still elusive. In this study, we developed a nov
Externí odkaz:
https://doaj.org/article/3e7828f51d034432ac7b5d9793be97fd
Autor:
Brittany E Jewell, An Xu, Dandan Zhu, Mo-Fan Huang, Linchao Lu, Mo Liu, Erica L Underwood, Jun Hyoung Park, Huihui Fan, Julian A Gingold, Ruoji Zhou, Jian Tu, Zijun Huo, Ying Liu, Weidong Jin, Yi-Hung Chen, Yitian Xu, Shu-Hsia Chen, Nino Rainusso, Nathaniel K Berg, Danielle A Bazer, Christopher Vellano, Philip Jones, Holger K Eltzschig, Zhongming Zhao, Benny Abraham Kaipparettu, Ruiying Zhao, Lisa L Wang, Dung-Fang Lee
Publikováno v:
PLoS Genetics, Vol 17, Iss 12, p e1009971 (2021)
Rothmund-Thomson syndrome (RTS) is an autosomal recessive genetic disorder characterized by poikiloderma, small stature, skeletal anomalies, sparse brows/lashes, cataracts, and predisposition to cancer. Type 2 RTS patients with biallelic RECQL4 patho
Externí odkaz:
https://doaj.org/article/c2342e4657584eb5b330edbc4ecee86b
Publikováno v:
Stem Cell Research, Vol 55, Iss , Pp 102483- (2021)
Externí odkaz:
https://doaj.org/article/21d18041d9bf4cb0bebb9d8ffbb64ee8
Publikováno v:
Stem Cell Research, Vol 54, Iss , Pp 102415- (2021)
Superoxide Dismutase 1 (SOD1) is an antioxidant enzyme that protects the cells from radical oxygen species. To study the behavior of endogenous SOD1 under a microscope, we genetically modified H1 human embryonic stem cells (hESCs) to express SOD1 fus
Externí odkaz:
https://doaj.org/article/3658ce25168442e09e850c19a5720b54