Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Dunfa, Peng"'
Autor:
Md Obaidul Islam, Krishnapriya Thangaretnam, Heng Lu, Dunfa Peng, Mohammed Soutto, Wael El-Rifai, Silvia Giordano, Yuguang Ban, Xi Chen, Daniel Bilbao, Alejandro V. Villarino, Stephan Schürer, Peter J. Hosein, Zheng Chen
Publikováno v:
Molecular Therapy: Oncolytics, Vol 30, Iss , Pp 286-300 (2023)
Esophageal adenocarcinoma (EAC) patients have poor clinical outcomes, with an overall 5-year survival rate of 20%. Smoking is a significant risk factor for EAC. The role of WEE1, a nuclear kinase that negatively regulates the cell cycle in normal con
Externí odkaz:
https://doaj.org/article/84c70702c03349cca06fdc726ba267ef
Autor:
Mohammed Soutto, Xing Zhang, Nadeem Bhat, Zheng Chen, Shoumin Zhu, Selma Maacha, Melanie Genoula, Omar El-Gazzaz, Dunfa Peng, Heng Lu, Oliver G. McDonald, Xi Steven Chen, Longlong Cao, Zekuan Xu, Wael El-Rifai
Publikováno v:
Redox Biology, Vol 69, Iss , Pp 102998- (2024)
Helicobacter pylori (H. pylori) is the leading risk factor for gastric carcinogenesis. Fibroblast growth factor receptor 4 (FGFR4) is a member of transmembrane tyrosine kinase receptors that are activated in cancer. We investigated the role of FGFR4
Externí odkaz:
https://doaj.org/article/d1ea9f85b0eb45219072afc3c9463aca
Autor:
Farah Ballout, Heng Lu, Lei Chen, Kannappan Sriramajayam, Jianwen Que, Zhipeng Meng, Timothy C. Wang, Silvia Giordano, Alexander Zaika, Oliver McDonald, Dunfa Peng, Wael El-Rifai
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-19 (2022)
Abstract Background Esophageal adenocarcinoma (EAC) is characterized by poor prognosis and low survival rate. Chronic gastroesophageal reflux disease (GERD) is the main risk factor for the development of Barrett’s esophagus (BE), a preneoplastic me
Externí odkaz:
https://doaj.org/article/edde4736e571425d8fff54e2221e9019
Autor:
Shoumin Zhu, Marwah Al-Mathkour, Longlong Cao, Shayan Khalafi, Zheng Chen, Julio Poveda, Dunfa Peng, Heng Lu, Mohammed Soutto, Tianling Hu, Oliver G. McDonald, Alexander Zaika, Wael El-Rifai
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 112005- (2023)
Summary: Infection with Helicobacter pylori (H. pylori) is the main risk factor for gastric cancer, a leading cause of cancer-related death worldwide. The oncogenic functions of cyclin-dependent kinase 1 (CDK1) are not fully understood in gastric tum
Externí odkaz:
https://doaj.org/article/692c8711cb8640889db364be69705399
Autor:
Kannappan Sriramajayam, Dunfa Peng, Heng Lu, Shoumin Zhou, Nadeem Bhat, Oliver G. McDonald, Jianwen Que, Alexander Zaika, Wael El-Rifai
Publikováno v:
Redox Biology, Vol 43, Iss , Pp 101970- (2021)
Background: Chronic gastroesophageal reflux disease (GERD) is a major risk factor for the development of metaplastic Barrett's esophagus (BE) and its progression to esophageal adenocarcinoma (EAC). Uncontrolled accumulation of reactive oxygen species
Externí odkaz:
https://doaj.org/article/dc058c0d86ab4f5b98843a1f10faef22
Autor:
Mohammed Soutto, Zheng Chen, Ajaz A. Bhat, Lihong Wang, Shoumin Zhu, Ahmed Gomaa, Andreia Bates, Nadeem S. Bhat, Dunfa Peng, Abbes Belkhiri, M. Blanca Piazuelo, M. Kay Washington, Xi Chen Steven, Richard Peek, Wael El-Rifai
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Trefoil factor 1 (TFF1) is a protein secreted by the gastric mucosa that protects against gastric tumourigenesis. Here, the authors show that TFF1 inhibits the oncogenic inflammatory response and IL-6-mediated STAT3 activation by interfering with the
Externí odkaz:
https://doaj.org/article/81a301b3784f4121a5bbe07006272423
Autor:
Zhangjian Zhou, Heng Lu, Shoumin Zhu, Ahmed Gomaa, Zheng Chen, Jin Yan, Kay Washington, Wael El-Rifai, Chengxue Dang, Dunfa Peng
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)
Abstract Background The incidence of esophageal adenocarcinoma (EAC) is rising rapidly in the US and Western countries. The development of Barrett’s esophagus (BE) and its progression to EAC have been linked to chronic gastroesophageal reflux disea
Externí odkaz:
https://doaj.org/article/33c7a895f39a4a6998639dc64987cf0d
Autor:
Farah Ballout, Heng Lu, Zheng Chen, Tianling Hu, Lei Chen, Mary Kay Washington, Wael El-Rifai, Dunfa Peng
Publikováno v:
Antioxidants, Vol 11, Iss 10, p 1859 (2022)
Esophageal adenocarcinoma (EAC), the predominant type of esophageal cancer in the United States, develops through Barrett’s esophagus (BE)-dysplasia-carcinoma cascade. Gastroesophageal reflux disease, where acidic bile salts refluxate into the esop
Externí odkaz:
https://doaj.org/article/f10132b013984b8c921edbc89ac1a501
Publikováno v:
Redox Biology, Vol 41, Iss , Pp 101894- (2021)
Esophageal adenocarcinoma (EAC) is the dominant form of esophageal malignancies in the United States and other industrialized countries. The incidence of EAC has been rising rapidly during the past four decades. Barrett's esophagus (BE) is the main p
Externí odkaz:
https://doaj.org/article/d8de7ac471914e9c885b67885c93bd78
Autor:
Sen Wang, Zheng Chen, Shoumin Zhu, Heng Lu, Dunfa Peng, Mohammed Soutto, Huma Naz, Richard Peek, Jr., Hao Xu, Alexander Zaika, Zekuan Xu, Wael El-Rifai
Publikováno v:
Redox Biology, Vol 28, Iss , Pp - (2020)
Background: Helicobacter pylori (H. pylori) infection is the main risk factor for gastric cancer. The role of antioxidant enzyme peroxiredoxin 2 (PRDX2) in gastric tumorigenesis remains unknown. In vitro (AGS and SNU-1 cell lines) and in vivo mouse m
Externí odkaz:
https://doaj.org/article/a33f528982954451bc7ec778d3e30369