Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Duncan R. Thompson"'
Autor:
Jonathan P. Graham, Mahesh J. Sanganee, Duncan R. Thompson, Catherine Priestley, Michael R. Webb, Thoralf Hartwig, Lesley A. Senior, Alan Ironmonger, Peter Hamilton
Publikováno v:
Organic Process Research & Development. 19:236-243
The development of a hydrogenation process and subsequent isolation for an intermediate in the manufacture of an active pharmaceutical ingredient is described. In-line process analytical technology (PAT) approaches were applied to gain process unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d392000352852041554461fb74ee3061
https://doi.org/10.1021/op500285x
https://doi.org/10.1021/op500285x
Autor:
Duncan R. Thompson, Howard W. Ward, George L. Reid, Adrian M. Daly, Samrat Mukherjee, Mark A. LaPack, Arani Chanda, David A. Foley, John D. Orr
Publikováno v:
Organic Process Research & Development. 19:63-83
The IQ Consortium reports on the current state of process analytical technology (PAT) for active pharmaceutical ingredient (API) development in branded pharmaceutical companies. The article uses an API process workflow (process steps from raw materia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25a80556abbaa8771557fd3b783dd5c4
https://doi.org/10.1021/op400358b
https://doi.org/10.1021/op400358b
Autor:
Richard G. Brereton, Diana L. Santos Ferreira, Louise A. Fido, Richard E. A. Escott, Duncan R. Thompson, Sila Kittiwachana
Publikováno v:
Analytical Chemistry. 82:5972-5982
A new approach for process monitoring is described, the self-organizing map quality control (SOMQC) index. The basis of the method is that SOM maps are formed from normal operating condition (NOC) samples, using a leave-one-out approach. The distance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34abe2453045770e49380ea099e6b182
https://doi.org/10.1021/ac100383g
https://doi.org/10.1021/ac100383g
Autor:
Richard E. A. Escott, Richard G. Brereton, Diana L. Santos Ferreira, Gavin R. Lloyd, Duncan R. Thompson, Louise A. Fido, Sila Kittiwachana
Publikováno v:
Journal of Chemometrics. 24:96-110
In process monitoring, a representative out-of-control class of samples cannot be generated. Here, it is assumed that it is possible to obtain a representative subset of samples from a single ‘in-control class’ and one class classifiers namely Q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc0b8c7d98e1c1e6ac748689b3391fb1
https://doi.org/10.1002/cem.1281
https://doi.org/10.1002/cem.1281
Autor:
Clemens Brechtelsbauer, Duncan R. Thompson, Christopher J. Lawrence, Yun Xu, François Xavier Ricard
Publikováno v:
The Canadian Journal of Chemical Engineering. 83:11-18
A review of tomography systems suitable for industrial implementation and design considerations for tomographic sensors has allowed the design of an ERT sensor compatible with stringent process requirements. In conjunction with a data acquisition sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7aeb0ca98b20d8fa199df0d44343aeda
https://doi.org/10.1002/cjce.5450830104
https://doi.org/10.1002/cjce.5450830104
Publikováno v:
Journal of Crystal Growth. 276:230-236
Modelling, design and control of organic batch cooling crystallization processes requires accurate solute concentration and supersaturation measurement. De-supersaturation rate controls the crystallization kinetics and determines the crystal size dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2245e8dbc397874195fd5da8ea06c2c7
https://doi.org/10.1016/j.jcrysgro.2004.11.301
https://doi.org/10.1016/j.jcrysgro.2004.11.301
Autor:
Louise A. Fido, Duncan R. Thompson, Richard E. A. Escott, Diana L. Santos Ferreira, Richard G. Brereton, Sila Kittiwachana
Publikováno v:
Journal of Chemometrics.
A method for multiblock statistical process control is described, involving the computation of Q and D statistics both for individual blocks and for the overall process using window consensus principal components analysis (WCPCA). The approach overco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccb3c6258469b7927b62f06c96c87800
https://doi.org/10.1002/cem.1322
https://doi.org/10.1002/cem.1322
Autor:
Richard E. A. Escott, Sila Kittiwachana, Richard G. Brereton, Louise A. Fido, Duncan R. Thompson, Diana L. Santos Ferreira
Publikováno v:
Journal of chromatography. A. 1213(2)
A continuous process was studied over 83.32 h using on-line high-performance liquid chromatography, involving the acquisition of 252 chromatograms. A method for analysis of these data using multivariate statistical process control on peak tables, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e78d57bd84fb2dd6b935434a3fce381
https://pubmed.ncbi.nlm.nih.gov/18996536
https://pubmed.ncbi.nlm.nih.gov/18996536
Autor:
Greg Jonas, Ian Mutton, Kaye Cattanach, Duncan R. Thompson, Bob Boughtflower, Keith Freebairn, Kathy Crane, Phil J. Borman, Asha Patel, Matt Sanders
Publikováno v:
Chirality.
Pharmaceutical companies have a continuous need to resolve new racemates. Analysis may be required in aqueous and nonaqueous media, or in the presence of several different sets of potentially interfering compounds. There is often a preparative requir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e906a386679e483ddcafe711ddf83f9f
https://pubmed.ncbi.nlm.nih.gov/12884369
https://pubmed.ncbi.nlm.nih.gov/12884369
Autor:
Richard G. Brereton, Duncan R. Thompson, Louise A. Fido, Richard E. A. Escott, Diana L. Santos Ferreira, Sila Kittiwachana
Publikováno v:
The Analyst. 134:1571
A continuous process is monitored by on-line HPLC in four separate campaigns, ranging in duration from 10 to 104 h. Methods are reported that allow the study of variation over all four campaigns using Multilevel Simultaneous Components Analysis, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43e542fc24e5652c797363b8074c779
https://doi.org/10.1039/b905285b
https://doi.org/10.1039/b905285b