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Autor:
Mariusz G. Banaszczyk, Charles P. Lollo, Patricia M. Mullen, Steven W. Brostoff, Alison T. Phillips, Arjang Amini, Christopher C. Coffin, Duncan P. Wu, Deborah Y. Kwoh, Dennis J. Carlo
Publikováno v:
Journal of Macromolecular Science, Part A. 36:1061-1084
Polycations have been used for gene delivery in vitro quite successfully, however, in vivo applications suffered from serum effects that lower the overall gene drug efficiency. PEG polymers have been used extensively to minimize serum effects and cre