Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Duncan L. Smith"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Congenital disorders of glycosylation (CDG) are rare genetic disorders with a spectrum of clinical manifestations caused by abnormal N-glycosylation of secreted and cell surface proteins. Over 130 genes are implicated and next generation seq
Externí odkaz:
https://doaj.org/article/4e4c9c0d95cd406caa41b947b1337197
Autor:
Alba Maiques-Diaz, Gary J. Spencer, James T. Lynch, Filippo Ciceri, Emma L. Williams, Fabio M.R. Amaral, Daniel H. Wiseman, William J. Harris, Yaoyong Li, Sudhakar Sahoo, James R. Hitchin, Daniel P. Mould, Emma E. Fairweather, Bohdan Waszkowycz, Allan M. Jordan, Duncan L. Smith, Tim C.P. Somervaille
Publikováno v:
Cell Reports, Vol 22, Iss 13, Pp 3641-3659 (2018)
Summary: Pharmacologic inhibition of LSD1 promotes blast cell differentiation in acute myeloid leukemia (AML) with MLL translocations. The assumption has been that differentiation is induced through blockade of LSD1’s histone demethylase activity.
Externí odkaz:
https://doaj.org/article/62c57f81e288426abeec246fcdba9441
Autor:
Richard T Timms, Lidia M Duncan, Iva A Tchasovnikarova, Robin Antrobus, Duncan L Smith, Gordon Dougan, Michael P Weekes, Paul J Lehner
Publikováno v:
PLoS Pathogens, Vol 9, Iss 11, p e1003772 (2013)
The Kaposi's sarcoma-associated herpesvirus gene products K3 and K5 are viral ubiquitin E3 ligases which downregulate MHC-I and additional cell surface immunoreceptors. To identify novel cellular genes required for K5 function we performed a forward
Externí odkaz:
https://doaj.org/article/1a8d90fd3ccd47ac9df00d5ca98de318
Autor:
Eamonn Morrison, Grazia Saturno, Leo Leung, Nathalie Dhomen, Caroline J. Springer, Filipa Lopes, L. Johnson, Haoran Tang, Dan Niculescu-Duvaz, Duncan L. Smith, Gianpiero Di Leva, Amaya Viros, Richard Marais
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-2 (2019)
Nature Communications
Nature Communications
Lysyl oxidase (LOX) remodels the tumour microenvironment by cross-linking the extracellular matrix. LOX overexpression is associated with poor cancer outcomes. Here, we find that LOX regulates the epidermal growth factor receptor (EGFR) to drive tumo
Autor:
Andrew R Clamp, Marilena Hadjidemetriou, Kostas Kostarelos, Duncan L. Smith, Zahraa S. Al-Ahmady, David Knight, Mariarosa Mazza, Sarah McAdam, Chelsey Thackeray, Grace Garner, Jane Rogan
Publikováno v:
Advanced materials (Deerfield Beach, Fla.). 31(4)
The self-assembled layered adsorption of proteins onto nanoparticle (NP) surfaces, once in contact with biological fluids, is termed the "protein corona" and it is gradually seen as a determinant factor for the overall biological behavior of NPs. Her
Publikováno v:
Privacy in Statistical Databases ISBN: 9783319997704
PSD
PSD
Data synthesis is a data confidentiality method which is applied to microdata to prevent leakage of sensitive information about respondents. Instead of publishing real data, data synthesis produces an artificial dataset that does not contain the real
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c6f9dbfc5e7de256a7a5df27b2f7495
https://doi.org/10.1007/978-3-319-99771-1_11
https://doi.org/10.1007/978-3-319-99771-1_11
Publikováno v:
Privacy in Statistical Databases ISBN: 9783319997704
PSD
PSD
Synthetic data generation has been proposed as a flexible alternative to more traditional statistical disclosure control (SDC) methods for limiting disclosure risk. Synthetic data generation is functionally distinct from standard SDC methods in that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::760d8a755808f73a17a0263b5068aa64
https://doi.org/10.1007/978-3-319-99771-1_9
https://doi.org/10.1007/978-3-319-99771-1_9
Autor:
Béla Ózsvári, Rebecca Lamb, Sacha J Howell, Kimberly J. Reeves, Anna Rita Cappello, Michael P. Lisanti, Duncan L. Smith, Marco Fiorillo, Amy L. Chadwick, Maria Peiris-Pagès, Federica Sotgia, Robert Clarke, Ubaldo E. Martinez-Outschoorn
Publikováno v:
Lamb, R, Fiorillo, M, Chadwick, A, Ozsvari, B, Reeves, K J, Smith, D, Clarke, R, Howell, S J, Cappello, A R, Martinez-Outschoorn, U E, Peiris Pages, M, Sotgia, F & Lisanti, M 2015, ' Doxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells: Implications for more effective radiation therapy. ', Oncotarget, vol. 6, no. 16, pp. 14005-1425 . https://doi.org/10.18632/oncotarget.4159
Oncotarget
Oncotarget
// Rebecca Lamb 1, 2 , Marco Fiorillo 1, 2, 3 , Amy Chadwick 1, 2 , Bela Ozsvari 1, 2 , Kimberly J. Reeves 1, 2 , Duncan L. Smith 4 , Robert B. Clarke 1 , Sacha J. Howell 1 , Anna Rita Cappello 3 , Ubaldo E. Martinez-Outschoorn 5 , Maria Peiris-Pages
Autor:
Yvonne Connolly, Iain M. Hagan, Marisa Alonso-Nuñez, Kayoko Tanaka, Agnes Grallert, Duncan L. Smith, Kuan Yoow Chan
Publikováno v:
Chan, K Y, Alonso-Nuñez, M, Grallert, A, Tanaka, K, Connolly, Y, Smith, D & Hagan, I 2017, ' Dialogue between centrosomal entrance and exit scaffold pathways regulates mitotic commitment ', The Journal of cell biology, vol. 216, no. 9, pp. 2795-2812 . https://doi.org/10.1083/jcb.201702172
The Journal of Cell Biology
The Journal of Cell Biology
Events at the fission yeast equivalent of the centrosome, the spindle pole body, determine the timing of mitotic commitment and mitotic exit. Previous work has established that events on Cut12 drive commitment, whereas events on a distinct scaffold,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860d59daad3dc4499120c745d25428e0
https://pure.manchester.ac.uk/ws/files/57875026/Chan_et_al_accepted.pdf
https://pure.manchester.ac.uk/ws/files/57875026/Chan_et_al_accepted.pdf
Autor:
David Knight, Kostas Kostarelos, Chelsey Thackeray, Duncan L. Smith, Jane Rogan, Andrew R Clamp, Zahraa S. Al-Ahmady, Marilena Hadjidemetriou, Mariarosa Mazza, Grace Garner, Sarah McAdam
Publikováno v:
Advanced Materials. 31:1970027