Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Duncan J. MacGregor"'
Autor:
Duncan J MacGregor, Gareth Leng
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 6, p e1007092 (2019)
The ventromedial nucleus of the hypothalamus (VMN) has an important role in diverse behaviours. The common involvement in these of sex steroids, nutritionally-related signals, and emotional inputs from other brain areas, suggests that, at any given t
Externí odkaz:
https://doaj.org/article/53618f9c49f14345b80da05c2a58e220
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180368 (2017)
Integrate-and-fire (IF) models can provide close matches to the discharge activity of neurons, but do they oversimplify the biophysical properties of the neurons? A single compartment Hodgkin-Huxley (HH) model of the oxytocin neuron has previously be
Externí odkaz:
https://doaj.org/article/855a8179764642f0a2ea6e65421d9238
Autor:
Duncan J. MacGregor
Hypothalamic vasopressin neurons are neuroendocrine cells which form part of the homeostatic systems that maintain osmotic pressure. In response to synaptic inputs encoding osmotic pressure and changes in plasma volume, they generate spike triggered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b55f45bd44e6a0926a5793152e53a40c
https://doi.org/10.1101/2022.06.27.497653
https://doi.org/10.1101/2022.06.27.497653
Autor:
Duncan J. MacGregor
Publikováno v:
MacGregor, D J 2022, ' Mathematical modelling of the oxytocin and vasopressin secretory system ', Current Opinion in Endocrine and Metabolic Research, vol. 24, 100341 . https://doi.org/10.1016/j.coemr.2022.100341
Magnocellular oxytocin and vasopressin neurons of the hypothalamus project to the posterior pituitary where they secrete their peptide hormone signals directly into the bloodstream. Their large anatomically distinct secretory mechanisms provide a uni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09be1fd50ce287b1c1eb467f7fe230ab
https://hdl.handle.net/20.500.11820/12517679-b480-4b2a-aaa9-3f49fc3ba26b
https://hdl.handle.net/20.500.11820/12517679-b480-4b2a-aaa9-3f49fc3ba26b
Autor:
Duncan J. MacGregor
Publikováno v:
MacGregor, D J 2021, ' Phasic spiking in vasopressin neurons : How and Why ', Journal of Neuroendocrinology, vol. 33, no. 11, e13042 . https://doi.org/10.1111/jne.13042
The plain title might have been an almost retro sounding grumpy retort, but it has inspired a journey of sorts, and something along the way I hope you won’t have come across before. An opinionated exploration of the distinctive phasic spiking patte
Autor:
Duncan J. MacGregor, Gareth Leng
Publikováno v:
Systems Medicine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7149b79ab3b9929f7bfc278d3bd597c
https://doi.org/10.1016/b978-0-12-801238-3.11371-6
https://doi.org/10.1016/b978-0-12-801238-3.11371-6
Autor:
Duncan J MacGregor, Gareth Leng
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 8, p e1003187 (2013)
Vasopressin neurons generate distinctive phasic patterned spike activity in response to elevated extracellular osmotic pressure. These spikes are generated in the cell body and are conducted down the axon to the axonal terminals where they trigger Ca
Externí odkaz:
https://doaj.org/article/c6029b66602d4b3f846810ebcb902642
Autor:
Duncan J MacGregor, Gareth Leng
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 10, p e1002740 (2012)
Vasopressin neurons, responding to input generated by osmotic pressure, use an intrinsic mechanism to shift from slow irregular firing to a distinct phasic pattern, consisting of long bursts and silences lasting tens of seconds. With increased input,
Externí odkaz:
https://doaj.org/article/08843f262b4e48cb85a1700f49af4014
Autor:
Gareth Leng, Duncan J. MacGregor
Publikováno v:
Leng, G & MacGregor, D 2018, ' Models in Neuroendocrinology ', Mathematical biosciences . https://doi.org/10.1016/j.mbs.2018.07.008
The neuroendocrine systems of the hypothalamus are critical for survival and reproduction, and are highly conserved throughout vertebrate evolution. Their roles in controlling body metabolism, growth and body composition, stress, electrolyte balance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a96e47e576954e248b8140dc17816394
https://www.pure.ed.ac.uk/ws/files/75121404/Models_in_Neuroendo_revised_Da_002_.pdf
https://www.pure.ed.ac.uk/ws/files/75121404/Models_in_Neuroendo_revised_Da_002_.pdf
Publikováno v:
Maícas-Royo, J, Leng, G & MacGregor, D J 2018, ' A predictive, quantitative model of spiking activity and stimulus-secretion coupling in oxytocin neurons ', Endocrinology . https://doi.org/10.1210/en.2017-03068
Endocrinology
Endocrinology
Oxytocin neurons of the rat hypothalamus project to the posterior pituitary, where they secrete their products into the bloodstream. The pattern and quantity of that release depends on the afferent inputs to the neurons, on their intrinsic membrane p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3420008f09e66d179a4ba67eeb5b0649
https://hdl.handle.net/20.500.11820/bd7f933e-4b36-4ec3-8b06-ea36a574b5fb
https://hdl.handle.net/20.500.11820/bd7f933e-4b36-4ec3-8b06-ea36a574b5fb