Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Duncan J. Hart"'
Autor:
John S. Lazo, Elizabeth R. Sharlow, Robert Cornelison, Duncan J. Hart, Danielle C. Llaneza, Anna J. Mendelson, Ettore J. Rastelli, Nikhil R. Tasker, Charles N. Landen, Peter Wipf
Publikováno v:
Biomolecules, Vol 11, Iss 7, p 969 (2021)
High grade serous ovarian cancer (OvCa) frequently becomes drug resistant and often recurs. Consequently, new drug targets and therapies are needed. Bioinformatics-based studies uncovered a relationship between high Protein Tyrosine Phosphatase of Re
Externí odkaz:
https://doaj.org/article/bd03bd9e93c14cfb8f63e736838dafd7
Autor:
Ettore J. Rastelli, Isabella K. Blanco, Sharon R. Garrott, Nikhil R. Tasker, James C. Burnett, John S. Lazo, Rebecca L. McCloud, Duncan J. Hart, Ku-Lung Hsu, Peter Wipf, Elizabeth R. Sharlow
Publikováno v:
J Pharmacol Exp Ther
Oncogenic protein tyrosine phosphatases (PTPs) are overexpressed in numerous human cancers but they have been challenging pharmacological targets. The emblematic oncogenic PTP4A tyrosine phosphatase family regulates many fundamental malignant process
Autor:
Danielle C. Llaneza, Peter Wipf, Nikhil R. Tasker, John S. Lazo, Duncan J. Hart, Robert Cornelison, Charles N. Landen, Anna J. Mendelson, Ettore J. Rastelli, Elizabeth R. Sharlow
Publikováno v:
Biomolecules
Biomolecules, Vol 11, Iss 969, p 969 (2021)
Volume 11
Issue 7
Biomolecules, Vol 11, Iss 969, p 969 (2021)
Volume 11
Issue 7
High grade serous ovarian cancer (OvCa) frequently becomes drug resistant and often recurs. Consequently, new drug targets and therapies are needed. Bioinformatics-based studies uncovered a relationship between high Protein Tyrosine Phosphatase of Re
Autor:
Sara Sannino, Jeffrey L. Brodsky, Ettore J. Rastelli, Duncan J. Hart, Peter Wipf, Elizabeth R. Sharlow, John S. Lazo
Publikováno v:
Bioorg Med Chem Lett
We developed JMS-053, a potent inhibitor of the dual specificity phosphatase PTP4A3 that is potentially suitable for cancer therapy. Due to the emerging role of the unfolded protein response (UPR) in cancer pathology, we sought to identify derivative
Autor:
Duncan J. Hart, Anna J. Mendelson, Elizabeth R. Sharlow, John Robert Cornelison, John S. Lazo, Peter Wipf, Christopher T. Letai, Ettore J. Rastelli
Publikováno v:
Cancer Research. 81:1460-1460
The protein tyrosine phosphatase 4A (PTP4A) family members, PTP4A1, PTP4A2 or PTP4A3, are overexpressed in many cancers, and this overexpression is associated with a distinct disadvantage to overall patient survival. Genetic knockdown or deletion of
Autor:
Duncan J. Hart, Ettore J. Rastelli, Anna J. Mendelson, John Robert Cornelison, Peter Wipf, Elizabeth R. Sharlow, John S. Lazo
Publikováno v:
Cancer Research. 81:1459-1459
High grade serous ovarian cancer (HGSOC) is the deadliest epithelial ovarian cancer (EOC) variant, with a bleak outcome that kills >14,000 women annually in the US. In past four decades, first line therapies have changed only modestly. While dramatic