Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Duncan J Smith"'
Autor:
Ruben Rosas, Rhiannon R Aguilar, Nina Arslanovic, Anna Seck, Duncan J Smith, Jessica K Tyler, Mair EA Churchill
Publikováno v:
eLife, Vol 12 (2023)
The histone chaperone chromatin assembly factor 1 (CAF-1) deposits two nascent histone H3/H4 dimers onto newly replicated DNA forming the central core of the nucleosome known as the tetrasome. How CAF-1 ensures there is sufficient space for the assem
Externí odkaz:
https://doaj.org/article/62285cb04994432d93263bf4766c7de6
Autor:
Natasha C Koussa, Duncan J Smith
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 8 (2021)
AbstractDuring lagging-strand synthesis, strand-displacement synthesis by DNA polymerase delta (Pol ∂), coupled to nucleolytic cleavage of DNA flap structures, produces a nick-translation reaction that replaces the DNA at the 5′ end of the preced
Externí odkaz:
https://doaj.org/article/7b5c71339a584c25b2fbdedfa902ee92
Autor:
Natasha C Koussa, Duncan J Smith
Publikováno v:
PLoS Genetics, Vol 17, Iss 1, p e1009322 (2021)
DNA polymerase delta (Pol δ) plays several essential roles in eukaryotic DNA replication and repair. At the replication fork, Pol δ is responsible for the synthesis and processing of the lagging-strand. At replication origins, Pol δ has been propo
Externí odkaz:
https://doaj.org/article/78cd603e095244c29d7ed6d0718d4ef3
Autor:
Sarina Y Porcella, Natasha C Koussa, Colin P Tang, Daphne N Kramer, Priyanka Srivastava, Duncan J Smith
Publikováno v:
PLoS Genetics, Vol 16, Iss 5, p e1008755 (2020)
During eukaryotic DNA replication, DNA polymerase alpha/primase (Pol α) initiates synthesis on both the leading and lagging strands. It is unknown whether leading- and lagging-strand priming are mechanistically identical, and whether Pol α associat
Externí odkaz:
https://doaj.org/article/9d355b1462f14bb5b571a304e9cd4eee
Autor:
Liana Goehring, Sarah Keegan, Sudipta Lahiri, Wenxin Xia, Michael Kong, Judit Jimenez-Sainz, Dipika Gupta, Ronny Drapkin, Ryan B. Jensen, Duncan J. Smith, Eli Rothenberg, David Fenyö, Tony T. Huang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract BRCA2 is a tumor suppressor protein responsible for safeguarding the cellular genome from replication stress and genotoxicity, but the specific mechanism(s) by which this is achieved to prevent early oncogenesis remains unclear. Here, we pro
Externí odkaz:
https://doaj.org/article/6eae7c91ca5e4e60a5079c4501597601
Autor:
Kate E. Coleman, Yandong Yin, Sarah Kit Leng Lui, Sarah Keegan, David Fenyo, Duncan J. Smith, Eli Rothenberg, Tony T. Huang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Here the authors provide mechanistic insights into how auto-cleavage of the USP1 deubiquitinase regulates DNA replication and genome stability. Implications for the targeting of USP1 activity via protein-DNA trapping in cancer therapy are discussed.
Externí odkaz:
https://doaj.org/article/000e432cb2774ebca453ed5d0d729f67
Autor:
Kate E. Coleman, Yandong Yin, Sarah Kit Leng Lui, Sarah Keegan, David Fenyo, Duncan J. Smith, Eli Rothenberg, Tony T. Huang
Publikováno v:
Nature communications. 13(1)
The deubiquitinase USP1 is a critical regulator of genome integrity through the deubiquitylation of Fanconi Anemia proteins and the DNA replication processivity factor, proliferating cell nuclear antigen (PCNA). Uniquely, following UV irradiation, US
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::251e7d1976a65f6e1b9fca6d84bdc973
https://pubmed.ncbi.nlm.nih.gov/35365626
https://pubmed.ncbi.nlm.nih.gov/35365626
Autor:
Duncan J. Smith, Natasha C. Koussa
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 8 (2021)
G3: Genes|Genomes|Genetics
G3: Genes|Genomes|Genetics
During lagging-strand synthesis, strand-displacement synthesis by DNA polymerase delta (Pol ∂), coupled to nucleolytic cleavage of DNA flap structures, produces a nick-translation reaction that replaces the DNA at the 5′ end of the preceding Okaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dcd8b53975547f8086c2f4098c71e48
https://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkab205
https://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkab205
Autor:
Vanessa Kellner, Duncan J. Smith
Publikováno v:
Molecular Cell. 80:6-8
Kapadia et al. (2020) use an innovative single-molecule imaging approach in yeast cells to measure chromatin association of individual replisome subunits, thereby challenging the notion that lagging-strand DNA polymerases frequently dissociate from r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddff541550e430623d241f49b2b14005
https://doi.org/10.1016/j.molcel.2020.09.010
https://doi.org/10.1016/j.molcel.2020.09.010
Publikováno v:
DNA Repair. 73:155-163
Ribonucleotides misincorporated by replicative DNA polymerases are by far the most common DNA lesion. The presence of ribonucleotides in DNA is associated with genome instability, causing replication stress, chromosome fragility, gross chromosomal re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5f8e900b2ed2ee9b80e2658c1b45bb
https://doi.org/10.1016/j.dnarep.2018.11.012
https://doi.org/10.1016/j.dnarep.2018.11.012