Zobrazeno 1 - 10
of 490
pro vyhledávání: '"Duncan J, Stewart"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Senescence refers to a cellular state marked by irreversible cell cycle arrest and the secretion of pro-inflammatory and tissue-remodeling factors. The senescence associated secretory phenotype (SASP) impacts the tissue microenvironment and provides
Externí odkaz:
https://doaj.org/article/fe3e6c8793db4d699b5939e73c25c2bb
Autor:
Yuan Tan, Mahmoud Salkhordeh, Aidan B. P. Murray, Luciana Souza-Moreira, Duncan J. Stewart, Shirley H. J. Mei
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
IntroductionCryopreservation is a critical process of cell products for achieving a commercial viability through wide scale adoption. By preserving cells in a lower temperature, cryopreservation enables a product to be off-the-shelf and ready for inf
Externí odkaz:
https://doaj.org/article/90ac76c60fd9445e9fb85e1fd10f87ad
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Background Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) are a promising cell-free therapy for acute lung injury (ALI). To date, no studies have investigated their biodistribution in ALI or discerned the timing of adminis
Externí odkaz:
https://doaj.org/article/167e6d7cf2a64263b653474a28528649
Autor:
Ramana Vaka, Sandrine Parent, Yousef Risha, Saad Khan, David Courtman, Duncan J. Stewart, Darryl R. Davis
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 80-93 (2023)
The cell origin-specific payloads within extracellular vesicles (EVs) mediate therapeutic bioactivity for a wide variety of stem cell types. In this study, we profiled the microRNA (miRNA) and protein cargos found within EVs produced by three clinica
Externí odkaz:
https://doaj.org/article/40ef917d1ead4837b93176841175fdea
Autor:
Sandrine Parent, Ramana Vaka, Yousef Risha, Clarissa Ngo, Pushpinder Kanda, Stanley Nattel, Saad Khan, David Courtman, Duncan J. Stewart, Darryl R. Davis
Publikováno v:
JCI Insight, Vol 8, Iss 15 (2023)
Almost half of patients recovering from open-chest surgery experience atrial fibrillation (AF) that results principally from inflammation in the pericardial space surrounding the heart. Given that postoperative AF is associated with increased mortali
Externí odkaz:
https://doaj.org/article/6ef884474dca479fb690d08f70f0be02
Autor:
Nicholas D. Cober, Katelynn Rowe, Yupu Deng, Ainara Benavente‐Babace, David W. Courtman, Michel Godin, Duncan J. Stewart
Publikováno v:
Journal of Extracellular Biology, Vol 2, Iss 6, Pp n/a-n/a (2023)
Abstract Extracellular vesicles (EVs) secreted by stem and progenitor cells have significant potential as cell‐free ‘cellular’ therapeutics. Yet, small EVs (
Externí odkaz:
https://doaj.org/article/e60ea3a27d15467880da060be29fd458
Autor:
Yuan Tan, Yan Wang, Luciana Souza-Moreira, Chi Wang, Aidan B. P. Murray, Mahmoud Salkhordeh, Maria Florian, Lauralyn McIntyre, Duncan J. Stewart, Shirley H. J. Mei
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Introduction: Influenza A virus (IAV)-induced acute lung injury (ALI) is characterized by pronounced proinflammatory activation and respiratory lung dysfunction. In this study, we performed deep immune profiling on airway and circulating immune cells
Externí odkaz:
https://doaj.org/article/99d02f9729934e89ae4e9e9f452d6e8c
Autor:
Rafael Soares Godoy, Nicholas D Cober, David P Cook, Emma McCourt, Yupu Deng, Liyuan Wang, Kenny Schlosser, Katelynn Rowe, Duncan J Stewart
Publikováno v:
eLife, Vol 12 (2023)
We sought to define the mechanism underlying lung microvascular regeneration in a model of severe acute lung injury (ALI) induced by selective lung endothelial cell ablation. Intratracheal instillation of DT in transgenic mice expressing human diphth
Externí odkaz:
https://doaj.org/article/6be9dda738014335b2a97fbb476221b2
Autor:
Mohammad M. Banoei, Lauralyn A. McIntyre, Duncan J. Stewart, Shirley H. J. Mei, David Courtman, Irene Watpool, John Granton, John Marshall, Claudia dos Santos, Keith R. Walley, Kenny Schlosser, Dean A. Fergusson, Brent W. Winston, on behalf of Canadian Critical Care Trials Group (CCCTG), on behalf of Canadian Critical Care Translational Biology Group (CCCTBG)
Publikováno v:
Metabolites, Vol 13, Iss 11, p 1142 (2023)
Sepsis is the result of an uncontrolled host inflammatory response to infection that may lead to septic shock with multiorgan failure and a high mortality rate. There is an urgent need to improve early diagnosis and to find markers identifying those
Externí odkaz:
https://doaj.org/article/3455d13757b24114a6f29090a6d96d18
Autor:
Ramana Vaka, Saad Khan, Bin Ye, Yousef Risha, Sandrine Parent, David Courtman, Duncan J. Stewart, Darryl R. Davis
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-13 (2022)
Abstract Background Although 90% of infections with the novel coronavirus 2 (COVID-19) are mild, many patients progress to acute respiratory distress syndrome (ARDS) which carries a high risk of mortality. Given that this dysregulated immune response
Externí odkaz:
https://doaj.org/article/df2f82b2d31644fda9fa6181d28a264b