Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Duncan I. Mackie"'
Autor:
Kathleen M. Caron, Remy Bonnavion, Stefan Offermanns, Christian S. M. Helker, Kyu-Won Kim, Hyouk-Bum Kwon, Duncan I. Mackie, D. Stephen Serafin, Stefan Guenter, Taekwon Son, Didier Y.R. Stainier, Alan Le Mercier
Publikováno v:
ACS Pharmacology & Translational Science
The G protein-coupled receptor 182 (GPR182) is an orphan GPCR, the expression of which is enriched in embryonic endothelial cells (ECs). However, the physiological role and molecular mechanism of action of GPR182 are unknown. Here, we show that GPR18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f6b59f36fc424fe418bdf3f457cc95
https://doi.org/10.1021/acsptsci.0c00020
https://doi.org/10.1021/acsptsci.0c00020
Publikováno v:
Trends Pharmacol Sci
Receptor activity-modifying proteins (RAMPs) interact with G-protein-coupled receptors (GPCRs) to modify their functions, imparting significant implications upon their physiological and therapeutic potentials. A resurging interest in identifying RAMP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::325f47029b3f404d7328fceb00b68d30
https://doi.org/10.1016/j.tips.2020.01.009
https://doi.org/10.1016/j.tips.2020.01.009
Autor:
Matthew Harris, Duncan I. Mackie, Reema B. Davis, Kathleen M. Caron, Graham Ladds, Smriti Singh, Danica Dy, Natalie R Nielsen
Publikováno v:
Proc Natl Acad Sci U S A
Receptor-activity-modifying proteins (RAMPs) are single transmembrane-spanning proteins which serve as molecular chaperones and allosteric modulators of G-protein-coupled receptors (GPCRs) and their signaling pathways. Although RAMPs have been previo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c83e944337cffd69f6c2bf29edf689a
https://doi.org/10.1073/pnas.1905561116
https://doi.org/10.1073/pnas.1905561116
Autor:
Kathleen M. Caron, Duncan I. Mackie, Asuka Inoue, Denise Wootten, John B. Pawlak, Mark Soave, Matthew Harris, Ho Yan Yeung, Suleiman Al-Sabah, Matthew T. Harper, Stephen J. Briddon, Graham Ladds, Peishen Zhao, Sabrina Carvalho, Dewi Safitri, Patrick M. Sexton, David R. Poyner, Sarah J Routledge, Stephen J. Hill, Bashaier Al-Zaid, Tin T. Truong
Gastric inhibitory polypeptide (GIP) receptor is a class B1 GPCR, that responds to GIP and physiologically potentiates glucose-stimulated insulin secretion. Like most class B1 GPCRs, GIPR has been shown to interact with RAMPs, yet the effects of RAMP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54cc5ceea92e5fc39a1bfce8ebe510e2
https://doi.org/10.1101/2021.04.08.436756
https://doi.org/10.1101/2021.04.08.436756
Autor:
Xuefeng Zhang, Jussara Hagen, Viviane P Muniz, Tarik Smith, Gary S Coombs, Christine M Eischen, Duncan I Mackie, David L Roman, Richard Van Rheeden, Benjamin Darbro, Van S Tompkins, Dawn E Quelle
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80228 (2013)
RABL6A (RAB-like 6 isoform A) is a novel protein that was originally identified based on its association with the Alternative Reading Frame (ARF) tumor suppressor. ARF acts through multiple p53-dependent and p53-independent pathways to prevent cancer
Externí odkaz:
https://doaj.org/article/6ed6ebb6df1d4336b6c9a48c9578d33f
A high throughput screen for RGS proteins using steady state monitoring of free phosphate formation.
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62247 (2013)
G-protein coupled receptors are a diverse group that are the target of over 50% of marketed drugs. Activation of these receptors results in the exchange of bound GDP for GTP in the Gα subunit of the heterotrimeric G-protein. The Gα subunit dissocia
Externí odkaz:
https://doaj.org/article/50146612edce4e198bebae5a5abfb843
Autor:
Fuad Al Mutairi, Daniel O. Kechele, John Simms, Natalie R Nielsen, Reema B. Davis, Joshua C. Snyder, Harvey J. Kliman, Marc G. Caron, Duncan I. Mackie, David R. Poyner, Jonathan S. Berg, Kathleen M. Caron
Publikováno v:
Journal of Experimental Medicine. 215:2339-2353
We report the first case of nonimmune hydrops fetalis (NIHF) associated with a recessive, in-frame deletion of V205 in the G protein–coupled receptor, Calcitonin Receptor-Like Receptor (hCALCRL). Homozygosity results in fetal demise from hydrops fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcfc53d52474114802de3cecacf95431
https://doi.org/10.1084/jem.20180528
https://doi.org/10.1084/jem.20180528
Publikováno v:
Cytokine. 109
The discovery that atypical chemokine receptors (ACKRs) can initiate alternative signaling pathways rather than classical G-protein coupled receptor (GPCR) signaling has changed the paradigm of chemokine receptors and their roles in modulating chemot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff95fcd940adef6cd97f0b025e1b0fa3
https://pubmed.ncbi.nlm.nih.gov/29903572
https://pubmed.ncbi.nlm.nih.gov/29903572
Autor:
Jon C. D. Houtman, Christopher R. Bodle, Josephine H. Schamp, Michael D. Henry, Michael A. James, Michael R. Miller, Jonathan A. Doorn, Michael P. Hayes, Duncan I. Mackie, David L. Roman
Regulator of G Protein Signaling (RGS) 17 is an overexpressed promoter of cancer survival in lung and prostate tumors, the knockdown of which results in decreased tumor cell proliferation in vitro. Identification of drug-like molecules inhibiting thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c5bb5934b17c8d63b504cbd92e0861
https://europepmc.org/articles/PMC5567870/
https://europepmc.org/articles/PMC5567870/
Autor:
David L. Roman, Duncan I. Mackie
Publikováno v:
SLAS Discovery. 16:869-877
In this study, the authors used AlphaScreen technology to develop a high-throughput screening method for interrogating small-molecule libraries for inhibitors of the Gα(o)-RGS17 interaction. RGS17 is implicated in the growth, proliferation, metastas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9da454e805b453250da85b4a0c925d5
https://doi.org/10.1177/1087057111410427
https://doi.org/10.1177/1087057111410427