Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Duncan Horlock"'
Autor:
Cheng Xue Qin, Lauren T. May, Renming Li, Nga Cao, Sarah Rosli, Minh Deo, Amy E. Alexander, Duncan Horlock, Jane E. Bourke, Yuan H. Yang, Alastair G. Stewart, David M. Kaye, Xiao-Jun Du, Patrick M. Sexton, Arthur Christopoulos, Xiao-Ming Gao, Rebecca H. Ritchie
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
G Protein-Coupled Receptors (GPCRs) can adopt different conformations, each linked to distinct cellular outcomes. Here the authors show that compound 17b, a novel agonist of the GPCR family member FPR, robustly activates cardioprotective but not detr
Externí odkaz:
https://doaj.org/article/662689059cf2432b82994c3add7656fb
Cardioprotective Actions of the Annexin-A1 N-Terminal Peptide, Ac2-26, Against Myocardial Infarction
Autor:
Cheng Xue Qin, Sarah Rosli, Minh Deo, Nga Cao, Jesse Walsh, Mitchel Tate, Amy E. Alexander, Daniel Donner, Duncan Horlock, Renming Li, Helen Kiriazis, Man K. S. Lee, Jane E. Bourke, Yuan Yang, Andrew J. Murphy, Xiao-Jun Du, Xiao Ming Gao, Rebecca H. Ritchie
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
The anti-inflammatory, pro-resolving annexin-A1 protein acts as an endogenous brake against exaggerated cardiac necrosis, inflammation, and fibrosis following myocardial infarction (MI) in vivo. Little is known, however, regarding the cardioprotectiv
Externí odkaz:
https://doaj.org/article/f7ef1d1ab6214a6981118ab16deba530
CXCR4 Antagonism Reduces Cardiac Fibrosis and Improves Cardiac Performance in Dilated Cardiomyopathy
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Background: Myocardial fibrosis is a key pathologic finding in the failing heart and is implicated as a cause of increased ventricular stiffness and susceptibility to ventricular arrhythmia. Neurohormonal mediators such as aldosterone and angiotensin
Externí odkaz:
https://doaj.org/article/502b64c5e50a4f3889bd7fe223e2366d
Autor:
Duncan Horlock, David M. Kaye, Catherine E. Winbanks, Xiao-Ming Gao, Helen Kiriazis, Daniel G. Donner, Paul Gregorevic, Julie R. McMullen, Bianca C. Bernardo
Publikováno v:
Pharmaceuticals, Vol 14, Iss 3, p 263 (2021)
Cardiac fibrosis is associated with most forms of cardiovascular disease. No reliable therapies targeting cardiac fibrosis are available, thus identifying novel drugs that can resolve or prevent fibrosis is needed. Tilorone, an antiviral agent, can p
Externí odkaz:
https://doaj.org/article/fe215dbd956040ef827924871d80abe7
Autor:
Po-Yin Chu, Ken Walder, Duncan Horlock, David Williams, Erin Nelson, Melissa Byrne, Karin Jandeleit-Dahm, Paul Zimmet, David M Kaye
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133616 (2015)
Heart failure (HF) is an increasingly recognized complication of diabetes. Cardiac fibrosis is an important causative mechanism of HF associated with diabetes. Recent data indicate that inflammation may be particularly important in the pathogenesis o
Externí odkaz:
https://doaj.org/article/2017589b6579474a951689c4da01ae7c
Autor:
David Williams, Kylie M Venardos, Melissa Byrne, Mandar Joshi, Duncan Horlock, Nicholas T Lam, Paul Gregorevic, Sean L McGee, David M Kaye
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104643 (2014)
BackgroundImpaired mitochondrial function is fundamental feature of heart failure (HF) and myocardial ischemia. In addition to the effects of heightened oxidative stress, altered nitric oxide (NO) metabolism, generated by a mitochondrial NO synthase,
Externí odkaz:
https://doaj.org/article/f11909e9fbd049feb59ddde30b0a8a64
Autor:
Matthew Snelson, Gavin W. Lambert, Assam El-Osta, Grant R Drummond, D. Donner, Melinda T. Coughlan, Helen Kiriazis, Aanthony Vinh, Duncan Horlock, Charles R. Mackay, Waled A. Shihata, Hamdi A. Jama, Beverly Giam, Tim D. Spector, Chad Johnson, Mark Ziemann, Xiao-Jun Du, April Fiedler, Kirill Tsyganov, Francine Z. Marques, David M. Kaye, Sarah E. Phillips, Amrita Vijay, Ana M. Valdes
Publikováno v:
Circulation. 141:1393-1403
Background: High blood pressure (BP) continues to be a major, poorly controlled but modifiable risk factor for cardiovascular death. Among key Western lifestyle factors, a diet poor in fiber is associated with prevalence of high BP. The impact of lac
Autor:
Charles R. Mackay, Hamdi A. Jama, Kirill Tsyganov, Gavin W. Lambert, D. Donner, Helen Kiriazis, Grant R Drummond, Sarah E. Phillips, Chad Johnson, Francine Z. Marques, Duncan Horlock, Waled A. Shihata, Antony Vinh, April Fiedler, Mark Ziemann, David M. Kaye, Matthew Snelson, Sam El-Osta, Beverly Giam, Xiao-Jun Du
Publikováno v:
Hypertension. 74
Background: High fibre intake is associated with lower blood pressure (BP) in epidemiological and clinical studies. Prebiotic fibre resists digestion in the upper gastrointestinal tract and is fermented by gut microbiota in the intestine. The impact
Autor:
Julie R. McMullen, David M. Kaye, D. Donner, Helen Kiriazis, Catherine E. Winbanks, Duncan Horlock, Xiao-Ming Gao, Bianca C. Bernardo, Paul Gregorevic
Publikováno v:
Pharmaceuticals, Vol 14, Iss 263, p 263 (2021)
Pharmaceuticals
Pharmaceuticals
Cardiac fibrosis is associated with most forms of cardiovascular disease. No reliable therapies targeting cardiac fibrosis are available, thus identifying novel drugs that can resolve or prevent fibrosis is needed. Tilorone, an antiviral agent, can p
Autor:
A. Ian Smith, April Fiedler, Sanjaya Kuruppu, Francine Z. Marques, Po-Yin Chu, Niwanthi W. Rajapakse, Beverly Giam, David M. Kaye, Helen Kiriazis, Duncan Horlock, Xiao-Jun Du
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Scientific Reports
Mechanisms underlying the renal pathology in cardiorenal syndrome (CRS) type 2 remain elusive. We hypothesised that renal glutathione deficiency is central to the development of CRS type 2. Glutathione precursor, N-acetylcysteine (NAC;40 mg/kg/day; 8