Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Duncan Haworth"'
Autor:
Anand S. Dutta, Amanda Rees, Alec Jamieson, Duncan Haworth, Rod S. Kittlety, Lorraine A. Hassall, Paul Gellert, James J. Gormley, Christopher F. Reilly, Peter J. Alcock, Christopher F. Hayward, Linda J. Wood, Mandy L. Crowther, Julie M. Moores
Publikováno v:
Journal of Peptide Science. 6:321-341
Potent monomeric and dimeric cyclic peptide very late antigen-4 (VLA-4) inhibitors have been designed based on a tetrapeptide (Ile-Leu-Asp-Val) sequence present in a 25-amino acid peptide (CS-1) reported in the literature. The peptides, synthesized b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25ceb93494fef4de3a60f6b947f394cc
https://doi.org/10.1002/1099-1387(200007)6:7<321::aid-psc259>3.0.co
https://doi.org/10.1002/1099-1387(200007)6:7<321::aid-psc259>3.0.co
Autor:
Paul Gellert, Peter J. Alcock, Duncan Haworth, Anand S. Dutta, Tracy Halterman, Roger Ferguson, Linda J. Wood, Julie M. Moores, Lorraine A. Hassall, Christopher F. Hayward, James J. Gormley, Christopher F. Reilly, Matthew M Coath, Jackie Moors, Amanda Rees, Rod S. Kittlety, Alec Jamieson
Publikováno v:
Journal of Peptide Science. 6:398-412
Additional structure–activity relationship studies on potent cyclic peptide inhibitors of very late antigen-4 (VLA-4) are reported. The new N- to C-terminal cyclic hexa-, hepta- and octapeptide inhibitors like cyclo(MeIle/MePhe-Leu-Asp-Val-X) (X=2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76652a961e3b5a12e5486a93642eb39f
https://doi.org/10.1002/1099-1387(200008)6:8<398::aid-psc270>3.0.co
https://doi.org/10.1002/1099-1387(200008)6:8<398::aid-psc270>3.0.co
Autor:
Peter J. Alcock, Amanda Rees, Anand S. Dutta, Alec Jamieson, Christopher F. Reilly, Duncan Haworth, Huw B Jones, Linda J. Wood, James J. Gormley
Publikováno v:
British Journal of Pharmacology. 126:1751-1760
1. Small, N- to C-terminal cyclized peptides containing the leucyl-aspartyl-valine (LDV) motif from fibronectin connecting segment-1 (CS-1) have been investigated for their effects on the adhesion of human T-lymphoblastic leukaemia cells (MOLT-4) to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8964fddd9cfecc984eabca246c2f17c6
https://doi.org/10.1038/sj.bjp.0702511
https://doi.org/10.1038/sj.bjp.0702511
Autor:
Frank Carey, Duncan Haworth
Publikováno v:
Prostaglandins. 31:33-45
It has been proposed that thromboxane synthase inhibition (TXSI) may be a useful form of anti-thrombotic therapy and that this is due, in part, to redirection of PGH2 metabolism in favour of PGI2, a potent vasodilator and anti-platelet agent. While r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5a61a02cc17f56af6e336b2bcdee588
https://doi.org/10.1016/0090-6980(86)90223-6
https://doi.org/10.1016/0090-6980(86)90223-6
Publikováno v:
Prostaglandins, Leukotrienes and Essential Fatty Acids. 36:57-61
In clinical and pre-clinical research the pharmacodynamics of selective 5-lipoxygenase and dual 5-lipoxygenase/cyclo-oxygenase inhibitors may be studied by direct RIA of plasma LTB4. Although immunoreactive LTB4 in plasma from A23187 stimulated human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e341a28cb68f1d82007ba55623aa0c86
https://doi.org/10.1016/0952-3278(89)90163-4
https://doi.org/10.1016/0952-3278(89)90163-4
Publikováno v:
Cardiovascular Research. 17:127-131
The plasma concentrations of immunoreactive thromboxane B2 and 6-keto-prostaglandin-F1 alpha were determined in coronary venous blood sampled from open-chested, anaesthetised beagle dogs by local vein catheterisation. Thromboxane levels were high imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a1eec33dd718a0903f10a30d85768c
https://doi.org/10.1093/cvr/17.3.127
https://doi.org/10.1093/cvr/17.3.127
Publikováno v:
Biochemical Society Transactions. 16:818-820
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c56f76beefb21c36b4eeb6005ad34665
https://doi.org/10.1042/bst0160818
https://doi.org/10.1042/bst0160818
Autor:
Duncan Haworth, Frank Carey
Publikováno v:
Prostaglandins. 31(1)
In the preceding paper we described the characterisation of an acute intravenous challenge model for the evaluation of the effects of thromboxane synthase inhibition (TXSI) on eicosanoid metabolism. Herein we describe the biochemical pharmacology of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa32a0c8c95823b3a7c33c2c3b7e9a1
https://pubmed.ncbi.nlm.nih.gov/3754057
https://pubmed.ncbi.nlm.nih.gov/3754057
Publikováno v:
Bioanalysis of Drugs and Metabolites, Especially Anti-Inflammatory and Cardiovascular ISBN: 9781475794267
Membrane-bound avachidonic acid is a precursor for PG and LT biosynthesis*. Members of this family of autocoids have been implicated in pathophysiology including regulation of microvascular blood flow and permeability, leukocyte chemotaxis, hyperalge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65de0c7d78ad91ea8ad18293e8ef101e
https://doi.org/10.1007/978-1-4757-9424-3_6
https://doi.org/10.1007/978-1-4757-9424-3_6
Publikováno v:
Clinical science (London, England : 1979). 67(6)
1. Levels of immunoreactive 6-oxo-prostaglandin F1α (6-oxo-PGF1α) and thromboxane B2 (TXB2) were measured in peripheral venous plasma in a group of volunteers and non-insulin dependent diabetic patients (NIDDS). Levels of these eicosanoids were clo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1caeb80e58ed597ff6077d90bd0d934d
https://pubmed.ncbi.nlm.nih.gov/6548428
https://pubmed.ncbi.nlm.nih.gov/6548428