Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Duncan H. Haynes"'
Publikováno v:
The Journal of Clinical Pharmacology. 44:1418-1424
Nonsteroidal anti-inflammatory drugs produce their analgesic and adverse effects through interaction with cyclooxygenase in a variety of tissues. The authors evaluated the therapeutic potential of administering a sustained-release formulation of flur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc5f5ec1f988c375c4fa22ba2983ff7
https://doi.org/10.1177/0091270004265703
https://doi.org/10.1177/0091270004265703
Autor:
Edwin W. Lojeski, David L. Wesche, Sheila M. Muldoon, Ben H. Boedeker, Saiid Bina, Duncan H. Haynes, Steven M. Karan
Publikováno v:
Anesthesia & Analgesia. 82:796-802
Dantrolene effectively treats malignant hyperthermia (MH) but the current form, Dantrium®, must be dissolved to a 0.33 mg/mL, pH 9.5 solution. This study describes lecithin-coated microcrystal formulations of sodium dantrolene (MC-NaD) and neutral d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::710b1abac35ecca12efcf4aa3da408ad
https://doi.org/10.1097/00000539-199604000-00021
https://doi.org/10.1097/00000539-199604000-00021
Publikováno v:
The Journal of Clinical Pharmacology. 34:699-702
This study was designed to determine if microencapsulated tetracaine would provide a longer duration of local anesthesia than nonmicroencapsulated (neat) tetracaine. Local anesthesia was determined by monitoring the response of the rat to tail clampi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d60c187ff93740a308efd6b28834e25d
https://doi.org/10.1002/j.1552-4604.1994.tb02026.x
https://doi.org/10.1002/j.1552-4604.1994.tb02026.x
Autor:
Duncan H. Haynes, Peter A. Valant
Publikováno v:
Journal of Fluorescence. 2:191-206
Determinations of pHcyt in suspensions of human platelets using BCECF [bis(carboxyethyl)-5(6)-carboxyfluorescein] can be seriously biased by leakage of the fluorescent indicator. Two methods ("pH jump" and "Mn(2+)") are presented for determining the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f861348c8a6ffb3ced33abf0d23f7b02
https://doi.org/10.1007/bf00866934
https://doi.org/10.1007/bf00866934
Autor:
Duncan H. Haynes, Jonas S. Johansson
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1105:40-50
Sodium nitroprusside (SNP) and other agents that elevate cGMP levels are known to inhibit the aggregation of human platelets. Published data suggest that cGMP attenuation of agonist-induced Ca2+ transients is involved in this effect. The present stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4be31216c204b08adc013b4d9ac18f2
https://doi.org/10.1016/0005-2736(92)90160-n
https://doi.org/10.1016/0005-2736(92)90160-n
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1105:19-28
The effect of cAMP on active Ca2+ extrusion across the plasma membrane of intact human platelets was studied using quin2, a fluorimetric indicator of free Ca2+ in the cytoplasmic compartment ([Ca2+]cyt). Elevations of cAMP were achieved by incubation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd425dbb3c048a0a4af18f0cd5f40648
https://doi.org/10.1016/0005-2736(92)90158-i
https://doi.org/10.1016/0005-2736(92)90158-i
Lipid and protein interactions in ca-promoted aggregation and fusion of chromaffin granule membranes
Publikováno v:
Biophysical journal. 37(1)
of purePCcannot beinduced to aggregate byionic perturbation;repulsive interaction between PC bilayers has been welldocumented. Vesicles composedofpurePScanbeinducedto aggregate by millimolar concentrations of divalentcations. Wehave proposed that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60c16de666ae01a4d8f305874c83a61
https://pubmed.ncbi.nlm.nih.gov/19431433
https://pubmed.ncbi.nlm.nih.gov/19431433
Autor:
Duncan H. Haynes, Deborah A. Dixon
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1029:274-284
The pH dependence of the Ca2(+)-transporting ATPase of bovine cardiac sarcolemma was determined in a membrane vesicle preparation. The maximal velocity (Vmax) at saturating external Ca2+ showed a sigmoidal pH dependence with maximal values in the 6.0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef378e027fe966e88a6f17a9e2400222
https://doi.org/10.1016/0005-2736(90)90164-j
https://doi.org/10.1016/0005-2736(90)90164-j
Publikováno v:
The Journal of membrane biology. 130(1)
This communication reports the kinetics of the Na+/Ca2+ exchanger and of the plasma membrane (PM) Ca2+ pump of the intact human platelet. The kinetic properties of these two systems were deduced by studying the rate of Ca2+ extrusion and its Na+ depe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af96caad9ff81ef9fb698b3719bfdf12
https://pubmed.ncbi.nlm.nih.gov/1469706
https://pubmed.ncbi.nlm.nih.gov/1469706
Publikováno v:
Biochimica et biophysica acta. 1107(2)
The effects of protein kinase C (PKC) on Ca2+ transport were investigated in human intact platelets. The indicator quin2 was used to measure the free cytoplasmic Ca2+ concentration ([Ca2+]cyt) and to search for possible PKC effects on the Ca(2+)-ATPa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7b0b4654714810a7d2f631fabd204c5
https://pubmed.ncbi.nlm.nih.gov/1380299
https://pubmed.ncbi.nlm.nih.gov/1380299