Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Duncan G. Wallace"'
Publikováno v:
Biology of Reproduction. 77:978-989
Phthalates are chemical plasticizers used in a variety of consumer products; in rodents, they alter testicular development, leading to decreased testosterone synthesis and maldevelopment of the reproductive tract. Here, our goals were to discover a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b5920c95226c084ea2a8362f88c971d
https://doi.org/10.1095/biolreprod.107.062950
https://doi.org/10.1095/biolreprod.107.062950
Publikováno v:
Toxicological Sciences. 93:369-381
Phthalate chemical plasticizers can damage the fetal and postnatal mammalian testis, but several aspects of the injury mechanism remain unknown. Using a genome-wide microarray, the profile of testicular gene expression changes was examined following
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfab0e2f7a261faf800425bd47630eb5
https://doi.org/10.1093/toxsci/kfl049
https://doi.org/10.1093/toxsci/kfl049
Publikováno v:
Toxicological Sciences. 74:393-406
Finasteride is a specific inhibitor of type II 5alpha-reductase, the enzyme that converts testosterone (T) to the more potent androgen receptor agonist dihydrotestosterone (DHT). In utero exposure to androgen receptor antagonists and T biosynthesis i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b1a602e52f912cca8a150b9ae23c8b7
https://doi.org/10.1093/toxsci/kfg128
https://doi.org/10.1093/toxsci/kfg128
Autor:
Duncan G. Wallace, Norman J. Barlow, Kevin W. Gaido, Paul M. D. Foster, Suzanne L. Phillips, Madhabananda Sar
Publikováno v:
Toxicological Sciences. 73:431-441
Di(n-butyl) phthalate (DBP) alters male reproductive development by decreasing testicular testosterone (T) production when fetuses are exposed on gestation days (GD) 12-21. Previous studies have shown altered gene expression for enzymes in the T bios
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3f621650f25c493b31c0d53f12ecbc5
https://doi.org/10.1093/toxsci/kfg087
https://doi.org/10.1093/toxsci/kfg087
Autor:
Kevin W. Gaido, Norman J. Barlow, David C. Dorman, Duncan G. Wallace, Paul M. D. Foster, Melanie F. Struve, Katie J. Turner
Publikováno v:
Toxicological Sciences. 68:174-183
Fenitrothion [0,0-dimethyl-O-(4-nitro-m-tolyl) phosphorothioate] is an organophosphate insecticide that has been shown to have antiandrogenic activity using in vitro and in vivo screening assays. Studies were performed to evaluate the ability of feni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f808b4a07cddcfae1a700d90dca8a5
https://doi.org/10.1093/toxsci/68.1.174
https://doi.org/10.1093/toxsci/68.1.174
Publikováno v:
Reproductive Toxicology. 16:19-28
Adult male rats previously exposed on gestation days (GD) 12–21 to di(n-butyl) phthalate (DBP) have reproductive tract malformations, particularly agenesis of the epididymis, decreased sperm production, and Leydig cell hyperplasia and adenomas. Alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7b9dc1ba2878942e8a485a0fd81efa
https://doi.org/10.1016/s0890-6238(01)00201-5
https://doi.org/10.1016/s0890-6238(01)00201-5
Publikováno v:
Toxicological Sciences. 55:143-151
Di(n-butyl) phthalate (DBP) is a commercially important plasticizer and ubiquitous environmental contaminant. Since previous, limited dose-response studies with DBP that reported alterations in male reproductive development and function failed to est
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f8a4be4b1c393913771168a9c821ea
https://doi.org/10.1093/toxsci/55.1.143
https://doi.org/10.1093/toxsci/55.1.143
Publikováno v:
Toxicological Sciences. 53:173-184
Phthalate esters are ubiquitous, low-level environmental contaminants that induce testicular toxicity in laboratory animals. The diester is rapidly metabolized in the gut to the monoester, which causes the testicular toxicity. Several physiologically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a314121256b9220ed6e6f4f3d4f343
https://doi.org/10.1093/toxsci/53.2.173
https://doi.org/10.1093/toxsci/53.2.173
Publikováno v:
Toxicological Sciences. 49:172-185
Di(2-ethylhexyl) phthalate (DEHP), a commercially important plasticizer, induces testicular toxicity in laboratory animals at high doses. After oral exposure, most of the DEHP is rapidly metabolized in the gut to mono(2-ethylhexyl) phthalate (MEHP),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f681cd46993e8c4b5ff9980bddd40516
https://doi.org/10.1093/toxsci/49.2.172
https://doi.org/10.1093/toxsci/49.2.172
Autor:
Tiwanda Masinde, Geoffrey Hurlburt, Mark F. Cesta, James C. Bonner, Duncan G. Wallace, Jessica P. Ryman-Rasmussen, Alexia J. Taylor
Publikováno v:
American journal of respiratory cell and molecular biology. 43(2)
Engineered multi-walled carbon nanotubes (MWCNT) represent a possible health risk for pulmonary fibrosis due to their fiber-like shape and potential for persistence in the lung. We postulated that bacterial lipopolysaccharide (LPS), a ubiquitous agen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb9599b7391ecbcb4ddfc606c67621d8
https://pubmed.ncbi.nlm.nih.gov/19738159
https://pubmed.ncbi.nlm.nih.gov/19738159