Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Duncan Forster"'
Autor:
Ioannis Bantounas, Parisa Ranjzad, Faris Tengku, Edina Silajdžić, Duncan Forster, Marie-Claude Asselin, Philip Lewis, Rachel Lennon, Antonius Plagge, Qi Wang, Adrian S. Woolf, Susan J. Kimber
Publikováno v:
Stem Cell Reports, Vol 10, Iss 3, Pp 766-779 (2018)
Summary: Human pluripotent stem cells (hPSCs) hold great promise for understanding kidney development and disease. We reproducibly differentiated three genetically distinct wild-type hPSC lines to kidney precursors that underwent rudimentary morphoge
Externí odkaz:
https://doaj.org/article/b48bfa9fa5e74a5a873fb8918db61e9b
Autor:
Kaye J. Williams, Ian Wilson, Duncan Hiscock, Caroline Dive, Adam McMahon, Gavin Brown, Cassandra Hodgkinson, Kathryn Simpson, Muhammad Babur, Alison Smigova, Marc Radigois, Jamil Gregory, Duncan Forster, Christopher J. Morrow, Roben G. Gieling, Natalie Burrows, Christopher Cawthorne
PDF file - 65 KB, Acute dosing with GDC-0941 leads to an increase in apoptotic signaling in in sensitive tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708657f7214f04cb186176d4644e0ee6
https://doi.org/10.1158/1535-7163.22499062
https://doi.org/10.1158/1535-7163.22499062
Autor:
Kaye J. Williams, Ian Wilson, Duncan Hiscock, Caroline Dive, Adam McMahon, Gavin Brown, Cassandra Hodgkinson, Kathryn Simpson, Muhammad Babur, Alison Smigova, Marc Radigois, Jamil Gregory, Duncan Forster, Christopher J. Morrow, Roben G. Gieling, Natalie Burrows, Christopher Cawthorne
PDF file - 75 KB, Uptake of 18F-FDG decreases significantly after ~18h of GDC-0941 treatment in U87, but not HCT116, tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3908af54495d0bd16afb22a825eda717
https://doi.org/10.1158/1535-7163.22499059.v1
https://doi.org/10.1158/1535-7163.22499059.v1
Autor:
Kaye J. Williams, Ian Wilson, Duncan Hiscock, Caroline Dive, Adam McMahon, Gavin Brown, Cassandra Hodgkinson, Kathryn Simpson, Muhammad Babur, Alison Smigova, Marc Radigois, Jamil Gregory, Duncan Forster, Christopher J. Morrow, Roben G. Gieling, Natalie Burrows, Christopher Cawthorne
PDF file - 74 KB, GDC-0941 inhibits hypoxic signaling in drug sensitive U87 tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c9b6737d17e4f28fb16df60e6c24445
https://doi.org/10.1158/1535-7163.22499065
https://doi.org/10.1158/1535-7163.22499065
Autor:
Kaye J. Williams, Ian Wilson, Duncan Hiscock, Caroline Dive, Adam McMahon, Gavin Brown, Cassandra Hodgkinson, Kathryn Simpson, Muhammad Babur, Alison Smigova, Marc Radigois, Jamil Gregory, Duncan Forster, Christopher J. Morrow, Roben G. Gieling, Natalie Burrows, Christopher Cawthorne
PDF file - 46 KB, Chronic dosing with GDC-0941 leads to an increase in MAP-kinase pathway signaling in sensitive tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506831cfbcee041e72d9d58acd491f0e
https://doi.org/10.1158/1535-7163.22499056.v1
https://doi.org/10.1158/1535-7163.22499056.v1
Autor:
Kaye J. Williams, Ian Wilson, Duncan Hiscock, Caroline Dive, Adam McMahon, Gavin Brown, Cassandra Hodgkinson, Kathryn Simpson, Muhammad Babur, Alison Smigova, Marc Radigois, Jamil Gregory, Duncan Forster, Christopher J. Morrow, Roben G. Gieling, Natalie Burrows, Christopher Cawthorne
The phosphoinositide 3-kinase (PI3K) pathway is deregulated in a range of cancers, and several targeted inhibitors are entering the clinic. This study aimed to investigate whether the positron emission tomography tracer 3′-deoxy-3′-[18F]fluorothy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e25f3849c4b0dfafe17b1719a5b971c6
https://doi.org/10.1158/1535-7163.c.6536056
https://doi.org/10.1158/1535-7163.c.6536056
Autor:
Kaye J. Williams, Ian Wilson, Duncan Hiscock, Caroline Dive, Adam McMahon, Gavin Brown, Cassandra Hodgkinson, Kathryn Simpson, Muhammad Babur, Alison Smigova, Marc Radigois, Jamil Gregory, Duncan Forster, Christopher J. Morrow, Roben G. Gieling, Natalie Burrows, Christopher Cawthorne
PDF file - 51 KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be3a97fb019e576337ce67b324210aa
https://doi.org/10.1158/1535-7163.22499050
https://doi.org/10.1158/1535-7163.22499050
Autor:
Adam Hurlstone, Adam W. McMahon, Kaye J. Williams, Emmanuelle Claude, Paul Lorigan, Michael P. Smith, Herman P. Spaink, Warwick B. Dunn, Katherine Hollywood, B. Ewa Snaar-Jagalska, Shuning He, Irene Barinaga-Rementeria Ramirez, Michael Fairclough, Michael Green, Jivko Kamarashev, Christos Evangelou, Raghavendar T. Nagaraju, Duncan Forster, Emrys A. Jones, Andrew P. Badrock, Hannah R. Johnston, Fiona Henderson
Figures S1-S9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697f43edb2bf6bdc192bdb9815714f7c
https://doi.org/10.1158/0008-5472.22423302.v1
https://doi.org/10.1158/0008-5472.22423302.v1
Autor:
Adam Hurlstone, Adam W. McMahon, Kaye J. Williams, Emmanuelle Claude, Paul Lorigan, Michael P. Smith, Herman P. Spaink, Warwick B. Dunn, Katherine Hollywood, B. Ewa Snaar-Jagalska, Shuning He, Irene Barinaga-Rementeria Ramirez, Michael Fairclough, Michael Green, Jivko Kamarashev, Christos Evangelou, Raghavendar T. Nagaraju, Duncan Forster, Emrys A. Jones, Andrew P. Badrock, Hannah R. Johnston, Fiona Henderson
From microarray analysis, genes from VGP melanocyte neoplasia whose transcripts are significantly up- or down-regulated compared to wild-type tissue that are associated with lipid metabolism and are not differentially expressed also in BRAFV600E or V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::416afdf3625885198b3a68172e8da154
https://doi.org/10.1158/0008-5472.22423296.v1
https://doi.org/10.1158/0008-5472.22423296.v1
Autor:
Adam Hurlstone, Adam W. McMahon, Kaye J. Williams, Emmanuelle Claude, Paul Lorigan, Michael P. Smith, Herman P. Spaink, Warwick B. Dunn, Katherine Hollywood, B. Ewa Snaar-Jagalska, Shuning He, Irene Barinaga-Rementeria Ramirez, Michael Fairclough, Michael Green, Jivko Kamarashev, Christos Evangelou, Raghavendar T. Nagaraju, Duncan Forster, Emrys A. Jones, Andrew P. Badrock, Hannah R. Johnston, Fiona Henderson
Alterations in lipid metabolism in cancer cells impact cell structure, signaling, and energy metabolism, making lipid metabolism a potential diagnostic marker and therapeutic target. In this study, we combined PET, desorption electrospray ionization-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ef019f98143a99dcfe4bbad4adf2eb2
https://doi.org/10.1158/0008-5472.c.6511461.v1
https://doi.org/10.1158/0008-5472.c.6511461.v1