Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Duncan C. Humphries"'
Autor:
Duncan C. Humphries, Richard A. O’Connor, Hazel L. Stewart, Tom M. Quinn, Erin E. Gaughan, Beth Mills, Gareth O.S. Williams, James M. Stone, Keith Finlayson, Martine Chabaud-Riou, Florence Boudet, Kevin Dhaliwal, Vincent Pavot
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionPulmonary-resident memory T cells (TRM) and B cells (BRM) orchestrate protective immunity to reinfection with respiratory pathogens. Developing methods for the in situ detection of these populations would benefit both research and clinica
Externí odkaz:
https://doaj.org/article/3f4db45336fc448c8b477921e7dd0a20
Autor:
Duncan C. Humphries, Ross Mills, Cecilia Boz, Brian J. McHugh, Nikhil Hirani, Adriano G. Rossi, Anders Pedersen, Hans T. Schambye, Robert J. Slack, Hakon Leffler, Ulf J. Nilsson, Wei Wang, Tariq Sethi, Alison C. Mackinnon
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Rationale: Galectin-3 (Gal-3) drives fibrosis during chronic lung injury, however, its role in acute lung injury (ALI) remains unknown. Effective pharmacological therapies available for ALI are limited; identifying novel concepts in treatment is esse
Externí odkaz:
https://doaj.org/article/012f04bc0d6f4ad19f571846d1bf801d
Autor:
Thomas H. Craven, Tashfeen Walton, Ahsan R. Akram, Emma Scholefield, Neil McDonald, Adam D.L. Marshall, Duncan C. Humphries, Bethany Mills, Thane A. Campbell, Annya Bruce, Joanne Mair, James W. Dear, David E. Newby, Adam T. Hill, Timothy S. Walsh, Chris Haslett, Kevin Dhaliwal
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Neutrophil activation is an integral process to acute inflammation and is associated with adverse clinical sequelae. Identification of neutrophil activation in real time in the lungs of patients may permit biological stratification of patien
Externí odkaz:
https://doaj.org/article/e52c1d397194451fb7aab2ac97bdda7d
Autor:
Duncan C. Humphries, Richard A. O’Connor, Daniel Larocque, Martine Chabaud-Riou, Kevin Dhaliwal, Vincent Pavot
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
There is increasing evidence that lung-resident memory T and B cells play a critical role in protecting against respiratory reinfection. With a unique transcriptional and phenotypic profile, resident memory lymphocytes are maintained in a quiescent s
Externí odkaz:
https://doaj.org/article/50ce235d18f047938dfb786049099ccb
Autor:
Duncan C. Humphries, Ross Mills, Ross Dobie, Neil C. Henderson, Tariq Sethi, Alison C. Mackinnon
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Rationale: Galectin-3 (Gal-3) is an immune regulator and an important driver of fibrosis in chronic lung injury, however, its role in acute lung injury (ALI) remains unknown. Previous work has shown that global deletion of galectin-3 reduces collagen
Externí odkaz:
https://doaj.org/article/514aa246c23f4d81a2d479d419fca3f5
Autor:
David A, Dorward, Christopher D, Lucas, Mary K, Doherty, Gavin B, Chapman, Emma J, Scholefield, Andrew, Conway Morris, Jennifer M, Felton, Tiina, Kipari, Duncan C, Humphries, Calum T, Robb, A John, Simpson, Phillip D, Whitfield, Christopher, Haslett, Kevin, Dhaliwal, Adriano G, Rossi
Publikováno v:
Thorax
Background Acute respiratory distress syndrome (ARDS) is an often fatal neutrophil-dominant lung disease. Although influenced by multiple proinflammatory mediators, identification of suitable therapeutic candidates remains elusive. We aimed to deline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a5de530743902be77e1f28d66b212249
https://pubmed.ncbi.nlm.nih.gov/28469031
https://pubmed.ncbi.nlm.nih.gov/28469031