Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Duncan C, Miller"'
Autor:
Pawel Lisowski, Selene Lickfett, Agnieszka Rybak-Wolf, Carmen Menacho, Stephanie Le, Tancredi Massimo Pentimalli, Sofia Notopoulou, Werner Dykstra, Daniel Oehler, Sandra López-Calcerrada, Barbara Mlody, Maximilian Otto, Haijia Wu, Yasmin Richter, Philipp Roth, Ruchika Anand, Linda A. M. Kulka, David Meierhofer, Petar Glazar, Ivano Legnini, Narasimha Swamy Telugu, Tobias Hahn, Nancy Neuendorf, Duncan C. Miller, Annett Böddrich, Amin Polzin, Ertan Mayatepek, Sebastian Diecke, Heidi Olzscha, Janine Kirstein, Cristina Ugalde, Spyros Petrakis, Sidney Cambridge, Nikolaus Rajewsky, Ralf Kühn, Erich E. Wanker, Josef Priller, Jakob J. Metzger, Alessandro Prigione
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-27 (2024)
Abstract Expansion of the glutamine tract (poly-Q) in the protein huntingtin (HTT) causes the neurodegenerative disorder Huntington’s disease (HD). Emerging evidence suggests that mutant HTT (mHTT) disrupts brain development. To gain mechanistic in
Externí odkaz:
https://doaj.org/article/340c015abcae4c679391b04ea77b6a41
Autor:
Duncan C. Miller, Pawel Lisowski, Carolin Genehr, Erich E. Wanker, Josef Priller, Alessandro Prigione, Sebastian Diecke
Publikováno v:
Stem Cell Research, Vol 68, Iss , Pp 103056- (2023)
Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by an abnormal length of CAG repeats in the gene HTT, leading to an elongated poly-glutamine (poly-Q) sequence in huntingtin (HTT). We used non-integrative Sendai virus to
Externí odkaz:
https://doaj.org/article/5ee51186bc8e4931ae2ca8332a5817d8
Autor:
Duncan C. Miller, Pawel Lisowski, Selene Lickfett, Barbara Mlody, Miriam Bünning, Carolin Genehr, Claas Ulrich, Erich E. Wanker, Sebastian Diecke, Josef Priller, Alessandro Prigione
Publikováno v:
Stem Cell Research, Vol 65, Iss , Pp 102976- (2022)
Huntington’s disease (HD) is a neurodegenerative disorder caused by abnormal glutamine (Q) expansion in the huntingtin protein due to elongated CAG repeats in the gene HTT. We used non-integrative episomal plasmids to generate induced pluripotent s
Externí odkaz:
https://doaj.org/article/bb9f7998ccc941c989eb4b530769af6a
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10405 (2022)
The potential of human-induced pluripotent stem cells (hiPSCs) to be differentiated into cardiomyocytes (CMs) mimicking adult CMs functional morphology, marker genes and signaling characteristics has been investigated since over a decade. The evoluti
Externí odkaz:
https://doaj.org/article/15f5467ee4b147789cd94fbe212a0531
Autor:
Duncan C. Miller, Suzannah J. Harnor, Mathew P. Martin, Richard A. Noble, Stephen R. Wedge, Celine Cano
Publikováno v:
Journal of Medicinal Chemistry. 66:4491-4502
Autor:
Gemma Davison, Mathew P. Martin, Shannon Turberville, Selma Dormen, Richard Heath, Amy B. Heptinstall, Marie Lawson, Duncan C. Miller, Yi Min Ng, James N. Sanderson, Ian Hope, Daniel J. Wood, Céline Cano, Jane A. Endicott, Ian R. Hardcastle, Martin E. M. Noble, Michael J. Waring
Publikováno v:
Journal of Medicinal Chemistry. 65:15416-15432
The development of ligands for biological targets is critically dependent on the identification of sites on proteins that bind molecules with high affinity. A set of compounds, called FragLites, can identify such sites, along with the interactions re
Autor:
Duncan C. Miller, Stephen C. Harmer, Ariel Poliandri, Muriel Nobles, Elizabeth C. Edwards, James S. Ware, Tyson V. Sharp, Tristan R. McKay, Leo Dunkel, Pier D. Lambiase, Andrew Tinker
Publikováno v:
Stem Cell Research, Vol 25, Iss C, Pp 233-244 (2017)
The class Ia anti-arrhythmic drug ajmaline is used clinically to unmask latent type I ECG in Brugada syndrome (BrS) patients, although its mode of action is poorly characterised. Our aims were to identify ajmaline's mode of action in human induced pl
Externí odkaz:
https://doaj.org/article/ca9d87c0e4fa49e08673fd8726d3486f
Autor:
Katherine S. Bridge, Kunal M. Shah, Yigen Li, Daniel E. Foxler, Sybil C.K. Wong, Duncan C. Miller, Kathryn M. Davidson, John G. Foster, Ruth Rose, Michael R. Hodgkinson, Paulo S. Ribeiro, A. Aziz Aboobaker, Kenta Yashiro, Xiaozhong Wang, Paul R. Graves, Michael J. Plevin, Dimitris Lagos, Tyson V. Sharp
Publikováno v:
Cell Reports, Vol 20, Iss 1, Pp 173-187 (2017)
As core components of the microRNA-induced silencing complex (miRISC), Argonaute (AGO) proteins interact with TNRC6 proteins, recruiting other effectors of translational repression/mRNA destabilization. Here, we show that LIMD1 coordinates the assemb
Externí odkaz:
https://doaj.org/article/dd86764956e7461fbbd192078a7216b7
Autor:
Loukia Yiangou, Albert Blanch-Asensio, Tessa de Korte, Duncan C Miller, Berend J van Meer, Mervyn P H Mol, Lettine van den Brink, Karina O Brandão, Christine L Mummery, Richard P Davis
Publikováno v:
Stem Cells. Oxford University Press ({OUP})
Stem Cells
Stem cells, 40(7), 655-668. Wiley-Blackwell
Stem Cells
Stem cells, 40(7), 655-668. Wiley-Blackwell
Electrical activity and intracellular Ca2+ transients are key features of cardiomyocytes. They can be measured using organic voltage- and Ca2+-sensitive dyes but their photostability and phototoxicity mean they are unsuitable for long-term measuremen
Autor:
Duncan C. Miller, Tristan Reuillon, Lauren Molyneux, Timothy Blackburn, Simon J. Cook, Noel Edwards, Jane A. Endicott, Bernard T. Golding, Roger J. Griffin, Ian Hardcastle, Suzannah J. Harnor, Amy Heptinstall, Pamela Lochhead, Mathew P. Martin, Nick C. Martin, Stephanie Myers, David R. Newell, Richard A. Noble, Nicole Phillips, Laurent Rigoreau, Huw Thomas, Julie A. Tucker, Lan-Zhen Wang, Michael J. Waring, Ai-Ching Wong, Stephen R. Wedge, Martin E. M. Noble, Celine Cano
Publikováno v:
Journal of Medicinal Chemistry. 65:6513-6540
The nonclassical extracellular signal-related kinase 5 (ERK5) mitogen-activated protein kinase pathway has been implicated in increased cellular proliferation, migration, survival, and angiogenesis; hence, ERK5 inhibition may be an attractive approac