Zobrazeno 1 - 10
of 7 265
pro vyhledávání: '"Duncan C"'
Autor:
Pawel Lisowski, Selene Lickfett, Agnieszka Rybak-Wolf, Carmen Menacho, Stephanie Le, Tancredi Massimo Pentimalli, Sofia Notopoulou, Werner Dykstra, Daniel Oehler, Sandra López-Calcerrada, Barbara Mlody, Maximilian Otto, Haijia Wu, Yasmin Richter, Philipp Roth, Ruchika Anand, Linda A. M. Kulka, David Meierhofer, Petar Glazar, Ivano Legnini, Narasimha Swamy Telugu, Tobias Hahn, Nancy Neuendorf, Duncan C. Miller, Annett Böddrich, Amin Polzin, Ertan Mayatepek, Sebastian Diecke, Heidi Olzscha, Janine Kirstein, Cristina Ugalde, Spyros Petrakis, Sidney Cambridge, Nikolaus Rajewsky, Ralf Kühn, Erich E. Wanker, Josef Priller, Jakob J. Metzger, Alessandro Prigione
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-27 (2024)
Abstract Expansion of the glutamine tract (poly-Q) in the protein huntingtin (HTT) causes the neurodegenerative disorder Huntington’s disease (HD). Emerging evidence suggests that mutant HTT (mHTT) disrupts brain development. To gain mechanistic in
Externí odkaz:
https://doaj.org/article/340c015abcae4c679391b04ea77b6a41
Autor:
Ananya Choudhury, Ian F Tannock, Mohini Varughese, Kimberley Reeves, Duncan C Gilbert, Hannah Louise Bromley
Publikováno v:
BMJ Oncology, Vol 3, Iss 1 (2024)
Objective To review the efficacy and safety of low-dose versus standard-dose enzalutamide, apalutamide or darolutamide treatment for metastatic prostate cancer.Methods and analysis Keyword searches in MEDLINE and EMBASE up to 1 June 2023, with forwar
Externí odkaz:
https://doaj.org/article/d2695181906746578f620e272a1afba5
Autor:
Nikos Papadimitriou, Andre Kim, Eric S. Kawaguchi, John Morrison, Virginia Diez-Obrero, Demetrius Albanes, Sonja I. Berndt, Stéphane Bézieau, Stephanie A. Bien, D Timothy Bishop, Emmanouil Bouras, Hermann Brenner, Daniel D. Buchanan, Peter T. Campbell, Robert Carreras-Torres, Andrew T. Chan, Jenny Chang-Claude, David V. Conti, Matthew A. Devall, Niki Dimou, David A. Drew, Stephen B. Gruber, Tabitha A. Harrison, Michael Hoffmeister, Jeroen R. Huyghe, Amit D. Joshi, Temitope O. Keku, Anshul Kundaje, Sébastien Küry, Loic Le Marchand, Juan Pablo Lewinger, Li Li, Brigid M. Lynch, Victor Moreno, Christina C. Newton, Mireia Obón-Santacana, Jennifer Ose, Andrew J. Pellatt, Anita R. Peoples, Elizabeth A. Platz, Conghui Qu, Gad Rennert, Edward Ruiz-Narvaez, Anna Shcherbina, Mariana C. Stern, Yu-Ru Su, Duncan C. Thomas, Claire E. Thomas, Yu Tian, Konstantinos K. Tsilidis, Cornelia M. Ulrich, Caroline Y. Um, Kala Visvanathan, Jun Wang, Emily White, Michael O. Woods, Stephanie L. Schmit, Finlay Macrae, John D. Potter, John L. Hopper, Ulrike Peters, Neil Murphy, Li Hsu, Marc J. Gunter, W. James Gauderman
Publikováno v:
EBioMedicine, Vol 104, Iss , Pp 105146- (2024)
Summary: Background: Consumption of fibre, fruits and vegetables have been linked with lower colorectal cancer (CRC) risk. A genome-wide gene-environment (G × E) analysis was performed to test whether genetic variants modify these associations. Meth
Externí odkaz:
https://doaj.org/article/6e63530a90ca4cdaa69e0f9d74663f4a
Autor:
Kyle G. Williams, Ramya Kongala, Donna M. Shows, Andrew J. Konecny, Duncan C. Hindmarch, Astrid S. Clarke, James D. Lord
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 1, Pp 119-130 (2024)
Background & Aims: Inflammatory bowel disease (IBD) causes a marked increase in the number of T cells in the intestinal mucosa. Debate exists about whether these excess cells arise from local clonal proliferation or recruitment from the periphery. Me
Externí odkaz:
https://doaj.org/article/ee9454018c844a7b80fe3559c671e348
Autor:
Pablo Nenclares, Adrian Larkeryd, Floriana Manodoro, Jen Y. Lee, Susan Lalondrelle, Duncan C. Gilbert, Marco Punta, Ben O’Leary, Antonio Rullan, Anguraj Sadanandam, Benny Chain, Alan Melcher, Kevin J. Harrington, Shreerang A. Bhide
Publikováno v:
Frontiers in Oncology, Vol 13 (2024)
BackgroundThe effect of chemoradiation on the anti-cancer immune response is being increasingly acknowledged; however, its clinical implications in treatment responses are yet to be fully understood. Human papillomavirus (HPV)-driven malignancies exp
Externí odkaz:
https://doaj.org/article/dfbf765b6f314f468732baee3f145325
Publikováno v:
BMJ Oncology, Vol 2, Iss 1 (2023)
Advances in the detection and treatment of cancer have translated into improved cancer survival rates and a growing population of cancer survivors. These include those living with cancer and individuals free of the disease following treatment. Epidem
Externí odkaz:
https://doaj.org/article/62da7c7b5dca4f8eb238b1b13b1d7abe
Publikováno v:
Geophysical Research Letters, Vol 50, Iss 19, Pp n/a-n/a (2023)
Abstract In 2022, the Hunga volcano eruption in Tonga generated atmospheric pressure waves that propagated globally and produced tsunamis in all the world's oceans. The largest pressure wave, with an amplitude of several hundred pascals, is the Lamb
Externí odkaz:
https://doaj.org/article/2b737108accb447c914b29a8608ced1e
Autor:
Duncan C. Miller, Pawel Lisowski, Carolin Genehr, Erich E. Wanker, Josef Priller, Alessandro Prigione, Sebastian Diecke
Publikováno v:
Stem Cell Research, Vol 68, Iss , Pp 103056- (2023)
Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by an abnormal length of CAG repeats in the gene HTT, leading to an elongated poly-glutamine (poly-Q) sequence in huntingtin (HTT). We used non-integrative Sendai virus to
Externí odkaz:
https://doaj.org/article/5ee51186bc8e4931ae2ca8332a5817d8
Autor:
Tim H Ward, Duncan C Gilbert, George Higginbotham, Chris M Morris, Valerie Speirs, Nicola J Curtin
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 8, Iss 1, Pp 3-13 (2022)
Abstract Half of all cancer patients receive radiotherapy, which makes a substantial contribution to their long‐term disease control/cure. There are significant inter‐patient differences in response, both in terms of efficacy and toxicity (freque
Externí odkaz:
https://doaj.org/article/09dae4cbd5104361b79da6053436b26d
Autor:
Duncan C. Humphries, Richard A. O’Connor, Hazel L. Stewart, Tom M. Quinn, Erin E. Gaughan, Beth Mills, Gareth O.S. Williams, James M. Stone, Keith Finlayson, Martine Chabaud-Riou, Florence Boudet, Kevin Dhaliwal, Vincent Pavot
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionPulmonary-resident memory T cells (TRM) and B cells (BRM) orchestrate protective immunity to reinfection with respiratory pathogens. Developing methods for the in situ detection of these populations would benefit both research and clinica
Externí odkaz:
https://doaj.org/article/3f4db45336fc448c8b477921e7dd0a20