Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Duncan Bruce Judd"'
Publikováno v:
Tetrahedron Letters. 38:9065-9068
The development of a novel solid phase synthesis of some 5-aminopyrazoles and derivatives is described. Reaction of hydrazines with solid supported β-keto-nitrile (1) affords 5-aminopyrazoles (2) the amino group of which is readily acylated or sulph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bf9f6f81aab117f20f66356e67d1d03
https://doi.org/10.1016/s0040-4039(97)10436-1
https://doi.org/10.1016/s0040-4039(97)10436-1
A convenient procedure for the solution phase preparation of 2-aminothiazole combinatorial libraries
Autor:
R. Storer, David Middlemiss, Stephen P. Watson, Nicholas Bailey, Duncan Bruce Judd, Anthony W. Dean
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1409-1414
A convenient procedure for the solution phase preparation of 2-aminothiazole combinatorial libraries is described. The library preparation is simple, practical, and effective, generating compounds based around a known pharmacophore in high yield and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fb115a85bbfa8fef8b1896df7a433a9
https://doi.org/10.1016/0960-894x(96)00241-7
https://doi.org/10.1016/0960-894x(96)00241-7
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::174886e9a235a42843bb077e9ca39324
https://doi.org/10.1002/chin.199444170
https://doi.org/10.1002/chin.199444170
Autor:
R. Storer, David Middlemiss, Anthony W. Dean, Stephen P. Watson, Duncan Bruce Judd, Nicholas Bailey
Publikováno v:
ChemInform. 27
A convenient procedure for the solution phase preparation of 2-aminothiazole combinatorial libraries is described. The library preparation is simple, practical, and effective, generating compounds based around a known pharmacophore in high yield and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b520bdbfa3a3db2193f14998aa5cfffd
https://doi.org/10.1002/chin.199642140
https://doi.org/10.1002/chin.199642140
Autor:
Duncan Bruce Judd, A. T. Merritt, N. Bailey, M. J. Deal, A. L. Gore, A. W. Dean, R. Storer, Anthony W. J. Cooper, M. C. Hawes, S. Travers
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16e8a3f19db466cd366d7ba2e0cbfc36
https://doi.org/10.1002/chin.199808288
https://doi.org/10.1002/chin.199808288
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::681fa21bc61875ef5655e2f679f6f384
https://doi.org/10.1002/chin.199836303
https://doi.org/10.1002/chin.199836303
Autor:
J Brain, David I. C. Scopes, Alan Naylor, David John Belton, Dearg S. Brown, Duncan Bruce Judd, Andrew B. McElroy, David E. Bays, N F Hayes, C. A. Meerholz
Publikováno v:
Journal of Medicinal Chemistry. 35:490-501
The syntheses of some 1-[(3,4-dichlorophenyl)acetyl]-2- [(alkylamino)methyl]piperidines and their activities as kappa-opioid receptor agonists are described. Selected structural modifications are made to the basic moiety and at the 2-, 3-, 4-, 5-, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3f028323c1d46911edf2b6c9402303
https://doi.org/10.1021/jm00081a009
https://doi.org/10.1021/jm00081a009
Autor:
Dearg S. Brown, Jane E. Lloyd, David I. C. Scopes, Michael J. Sheehan, Ann G. Hayes, P.J. Birch, Duncan Bruce Judd, Andrew B. McElroy
Publikováno v:
Journal of Medicinal Chemistry. 35:48-56
A series of trans-3-(6- and 7-substituted-decahydro-4a-isoquinolinyl)phenols and trans-3-(octahydro-4a-isoquinolinyl)phenols have been synthesized as potential opioid analgesics. Using a combination of in vitro and in vivo test systems, the receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abfdaed92f1ea43ad22a2b1e08595b9f
https://doi.org/10.1021/jm00079a005
https://doi.org/10.1021/jm00079a005
Autor:
Duncan Bruce Judd, A. G. Hayes, Alan Naylor, H. Rogers, P.J. Birch, M.B. Tyers, David I. C. Scopes, N.J. Hayward
Publikováno v:
British Journal of Pharmacology. 103:1819-1823
1. The effect of a novel, highly potent and selective kappa-opioid receptor agonist, GR89696, has been evaluated in two animal models of cerebral ischaemia: transient bilateral carotid artery occlusion in the Mongolian gerbil and permanent, unilatera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5660852457bea16bb2f37b1f394ad5e1
https://doi.org/10.1111/j.1476-5381.1991.tb09869.x
https://doi.org/10.1111/j.1476-5381.1991.tb09869.x
Publikováno v:
Journal of the American Chemical Society. 126(4)
A general new method for the preparation of sulfonamides and activated sulfonate esters by the direct coupling of sulfonic acid salts with amines and alcohols using the reagent triphenylphosphine ditriflate is described. A new reusable polymer-suppor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d3d2ef50b649ac17d28602ebd7126b3
https://pubmed.ncbi.nlm.nih.gov/14746462
https://pubmed.ncbi.nlm.nih.gov/14746462