Výsledky vyhledávání - "Duncan Bloor-Young"

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

Autor: Duncan Bloor-Young, Sabine Hilfiker, Ling-ling Zhang, Dev Churamani, Philip G. Woodman, Sandip Patel, Grant C. Churchill, Patricia Gómez-Suaga, Berta Luzón-Toro

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Human Molecular Genetics

Mutations in the leucine-rich repeat kinase-2 (LRRK2) gene cause late-onset Parkinson's disease, but its physiological function has remained largely unknown. Here we report that LRRK2 activates a calcium-dependent protein kinase kinase-Î² (CaMKK-Î

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0861db26c36c7af8115babe320086544
https://doi.org/10.1093/hmg/ddr481

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NAADP Activates Two-Pore Channels on T Cell Cytolytic Granules to Stimulate Exocytosis and Killing

Autor: Antony Galione, Anthony J. Morgan, Charlotte M. Snead, Grant C. Churchill, John Parrington, Stuart J. Conway, Vincenzo Cerundolo, Ji Li Chen, Lianne C. Davis, Eugene Shenderov, Duncan Bloor-Young, Megan N. Stanton-Humphreys

Publikováno v: Current Biology

Summary A cytotoxic T lymphocyte (CTL) kills an infected or tumorigenic cell by Ca2+-dependent exocytosis of cytolytic granules at the immunological synapse formed between the two cells. Although inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ relea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d051083519c2dc0590e6d383a8fb2df

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Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Regulates Autophagy in Cultured Astrocytes

Autor: Roberta Sessa Stilhano, Sang Won Han, Claudia Bincoletto, Lucia Garcez do Carmo, Gian Maria Fimia, Mauro Piacentini, Soraya S. Smaili, Gustavo J.S. Pereira, Rodrigo Portes Ureshino, Hanako Hirata, Grant C. Churchill, Sandip Patel, Duncan Bloor-Young

Publikováno v: Journal of Biological Chemistry. 286:27875-27881

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca(2+)-mobilizing messenger that in many cells releases Ca(2+) from the endolysosomal system. Recent studies have shown that NAADP-induced Ca(2+) mobilization is mediated by the two-po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfede8422121a5395f28c5af5274645c
https://doi.org/10.1074/jbc.c110.216580

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NAADP mediates ATP-induced Ca2+ signals in astrocytes

Autor: Grant C. Churchill, Alexander M. Lewis, Fernado Picatoste, Miquel Barceló-Torns, Albert Gubern, Duncan Bloor-Young, Roser Masgrau, Enrique Claro, David Barneda

Publikováno v: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Recercat. Dipósit de la Recerca de Catalunya
instname

Altres ajuts: MSSSI/PI05-1723 Intracellular Ca2+ signals provide astrocytes with a speciﬁc form of excitability that enables them to regulate synaptic transmission. In this study, we demonstrate that NAADP-AM, a membrane-permeant analogue of the ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395504a12051d88af344b05955854d84
https://doi.org/10.1016/j.febslet.2011.05.062

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Release of calcium from endolysosomes increases calcium influx through N-type calcium channels: Evidence for acidic store-operated calcium entry in neurons

Autor: Jonathan D. Geiger, Nicholas H. Geiger, Liang Hui, Duncan Bloor-Young, Xuesong Chen, Grant C. Churchill

Publikováno v: Cell calcium. 58(6)

Neurons possess an elaborate system of endolysosomes. Recently, endolysosomes were found to have readily releasable stores of intracellular calcium; however, relatively little is known about how such 'acidic calcium stores' affect calcium signaling i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db77f8df16a861be7b37d899fc0a3ba
https://pubmed.ncbi.nlm.nih.gov/26475051

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The Involvement of NAADP and Two-Pore Ca2+ Channels in the Cardiac Beta-Adrenergic Response

Autor: Derek A. Terrar, Margarida Ruas da Silva, Duncan Bloor-Young, Chichonyi Aubrey Kalungia, Rebecca A. Bayliss, John Parrington, Emma L. Bolton, Grant C. Churchill, Antony Galione

Publikováno v: Biophysical Journal. 104(2)

NAADP is a potent endogenous Ca2+-mobilising agent with actions in many cell types, including cardiac myocytes1,2. Our previous work suggests that NAADP causes Ca2+ release from an acidic endolysosomal store, leading to additional Ca2+ uptake by the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0a1f1435fae90c6d88267f723e18c65

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β-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart

Autor: Grant C. Churchill, Ali Roomi, Duncan Bloor-Young, Alexander M. Lewis, Derek A. Terrar, Parvinder K. Aley, Clive Garnham, Luke Sanders, Katherine Shipman, Roser Masgrau, Antony Galione, Claire Paramore, Justyn M. Thomas

Publikováno v: Biochemical and biophysical research communications. 427(2)

Evidence suggests that ß-Adrenergic receptor signaling increases heart rate and force through not just cyclic AMP but also the Ca 2+-releasing second messengers NAADP (nicotinic acid adenine dinucleotide phosphate) and cADPR (cyclic ADP-ribose). Nev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2585ed219356db98c4db93b982e49e
https://pubmed.ncbi.nlm.nih.gov/22995315

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Synthesis and use of cell-permeant cyclic ADP-ribose

Autor: Daniel G. Rosen, James Squires, Alexander M. Lewis, Duncan Bloor-Young, Gareth Waters, Raman Parkesh, Sridhar R. Vasudevan, Grant C. Churchill

Publikováno v: Biochemical and biophysical research communications. 418(2)

Cyclic ADP-ribose (cADPR) is a second messenger that acts on ryanodine receptors to mobilize Ca(2+). cADPR has a net negative charge at physiological pH making it not passively membrane permeant thereby requiring it to be injected, electroporated or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29198903ed6f2f883d9632307583a160
http://ora.ox.ac.uk/objects/uuid:2e70b7b1-a5fa-4e46-afd5-14c5c90d18c5

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NAADP is a Physiologically-Relevant Calcium Mobilising Compound in Atrial Myocytes

Autor: Rebecca A. Bayliss, Grant C. Churchill, Derek A. Terrar, Duncan Bloor-Young

Publikováno v: Biophysical Journal. 102(3)

NAADP is a calcium mobilising compound acting via a two-pool mechanism (1). In both ventricular and atrial myocytes, NAADP increases cellular calcium transients through enhancement of SR calcium load (2,3).In ventricular myocytes Ned-19, a non-compet

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CaMKII-Mediated Amplification is Essential to NAADP Signalling in Cardiac Myocytes

Autor: Emma L. Bolton, Antony Galione, Rebecca A. Bayliss, Duncan Bloor-Young, Grant C. Churchill, Derek A. Terrar, Wee Khang Lin

Publikováno v: Biophysical Journal. (2):242a

NAADP is a highly potent endogenous Ca2+-mobilising second-messenger forming part of the beta-adrenergic response in cardiac myocytes12. Our previous work suggests NAADP causes Ca2+-release from acidic endolysosomal stores, leading to additional upta

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